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Flashcards in Host Defense Deck (33):
1

What is innate immunity?

complement pathways

2

What is adaptive immunity?

primary and secondary humoral immune response, antibody, response is specific for the antigen and memory is generated

3

What does C1 binding to C-reactive protein on the pathogen surface activate?

the classical pathway of complement factors

4

What is the classical complement pathway?

Antibody + Antigen

5

What is the route of the classical pathway?

Activated by binding of antibody to antigen, C1 reactive protein binding, inital complement component- C1q. C1r, C1s, C4, C2

6

What is C3 convertase?

C4bC2b

7

What is C5 convertase?

C4bC2bC3b

8

What is the route of the lectin pathway?

Activated by mannan binding lectin (MBL), MBL-assoicated serine protease-2 (MASP-2), initial complement component- C4, C2

9

What is the route of the alternative pathway?

Activated by contact of microbial cell wall with C3, initial complement component-C3, Factor B, Factor D and properdin

10

What does MAC cause?

lysis

11

What does C3b cause?

opsonization

12

What does C3a and C5a cause?

activation of inflammatory response

13

What is humoral immunity?

antibodies secreted by antigen-activated B cels and their plasma cells

14

What is secondary humoral response?

shorter lag phase, greater magntiude

15

What does Ig stand for?

Immunoglobulin

16

What are epitopes?

Antigen determinants

17

What are paratopes?

the part of an antibody which recognize an antigen, the antigen binding site of an antibody

18

What two parts does an antibody have?

Fc (bottom) and Fab 2(top)

19

T or F: B-cell receptors and antibodies recognize native protein antigens?

True

20

What is MHC?

Major histocompatiblity complex

21

What do CD8 and T cells function as?

cytotoxic T lymphocytes

22

What is cell mediated immunity?

antigen-activated T cells and the cytokines they create

23

What do TCRs recognize?

Ag on MHC

24

What are the two classes of MHC proteins?

MHC I & II

25

What does MHC I distribute, function and result?

nucleated cells
cytotoxic T cells to Ag
T cell mediated toxicity

26

What does MHC II distribute, function and result?

B cells and macrophages
T helper cell to Ag
T cell mediated help

27

T or F: MHC II can activate macrophages and B cells

True

28

What are APC's?

macrophages, dendrites and B cells

29

T or F: APC's must contact with MHC II

True

30

T or F: CD8 T cells are MHC I restricted ?

True

31

T or F: CD4 T cells are MHC II restricted?

True

32

What is ADCC?

antibody dependent cell mediated cytotoxicity

33

T or F: ADCC is a response to kill helminths?

True