HRT Flashcards
1
Q
HRT
MOA
A
Giving additional oestrogen, results in the decrease of bone resorption as it inhibits osteoclasts by decreasing transcription genes, RANKL, cytokines, etc and increases osteoblast proliferation. Does not increase bone mass but slows bone loss
2
Q
HRT
Abs/Distrb/Elim
A
Can be given orally and non-orally
3
Q
HRT
Clinical use
A
Risk outweigh benefits FOR use in osteoporosis
4
Q
HRT
Adverse effects
A
Venous thromboembolism
Breast and cervical cancer
