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Calcium Homeostasis SM > SERM : Raloxifene > Flashcards

SERM : Raloxifene Flashcards

Antiresorptive Agents - slow rate bone loss

1
Q

Raloxifene
MOA

A

Modifies gene expression by binding to the nuclear oestrogen receptors differentially in tissue, to turn on/off transcription

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2
Q

Raloxifene
Abs/Distrb/Elim

A

Given orally, undergoes first-pass metabolism. Bioavailabity ~ 2%.
Plasma half life ~ 32h

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3
Q

Raloxifene
Clinical use

A

Indicated alternative to bisphosphonate prevention for osteoporosis in postmenopausal women at risk of breast cancer

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4
Q

Raloxifene
Adverse effects

A

Increased risk of venous thromboembolism
(reduced risk of breast cancer and no risk of endometrial or ovarian cancer comparted to HRT)

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Calcium Homeostasis SM (5 decks)

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