Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

OMPR > HSV > Flashcards

HSV Flashcards

(34 cards)

Start Studying
1
Q

Types of Herpes Viruses

A 
HHV-1: HSV-1-Herpes simplex virus type 1
HHV-2: HSV-2-Herpes simplex virus type 2 
HHV-3: VZV-Varicella zoster virus
HHV-4: EBV-Epstein Barr virus 
HHV-5: CMV-Cytomegalovirus
HHV-6: Sixth disease/Roseola
HHV-7: Roseola 
HHV-8: KSHV-Kaposi sarcoma-associated herpesvirus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

HHV-1/HSV1 Cells of Latency

A

Sensory Ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

HHV-2/HSV2 Cells of Latency

A

Sensory Ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

HHV-3/VZV: Cells of Latency

A

Sensory ganglia (dorsal root ganglia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

HHV-4/EBV: Cells of Latency

A

B-Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

HHV-5/CMV Cells of Latency

A

Myeloid cells, salivary gland cells, endothelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

HHV-6 Cells of Latency

A

CD4+ T-Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

HHV-7 Cells of Latency

A

CD4+ T-Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

HHV-8 Cells of Latency

A

B-lymphocytes (latency), endothelial cells (Kaposi sarcoma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Primary Infection of Herpes

A

Acute (primary) herpetic gingivostomatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Recurrent Infection of Herpes

A

Herpes labialis

Intra-oral herpes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

HSV-pathogenesis-Primary Infection

A
  • Usually young age
  • Often asymptomatic
  • Symptomatic=Primary herpetic gingivostomatitis
  • In adults is usually pharyngotonsillitis
  • Spread through infected saliva or active lesions
  • Incubation period=3-9 days
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Primary Herpetic Gingivostomatitis Clinical Features

A
  • Cervical lymphadenopathy
  • Chills
  • Fever
  • Nausea
  • Anorexia
  • Irritability
  • Sores in mouth
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Primary Herpetic Gingivostomatitis Oral Lesions

A
  • Ulcerations on fixed and movable mucosa
  • Variable number of lesions
  • Ulcers coalesce and form larger irregular ulcerations
  • Gingiva enlarged and painful
  • Resolution in 5-7 days (latency in trigeminal ganglion)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

HSV- diagnosis

A 
Clinical**
Culture (may take 2 weeks)
Tissue biopsy
Cytologic smear (less invasive)**
Serologic testing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

HSV-Histopathology

Study These Flashcards
A

Molding
Margination
Multinucleation

Also Tzanck cells

17
Q

Lab Results

Study These Flashcards
A

Positive IgM and Negative IgG = Acute/Recent Infection

Negative IgM and positive IgG = established infection

18
Q

Treatment primary HSV

Study These Flashcards
A
  • Supportive/Palliative Treatment
  • Fluids, nutrition, rest, avoid spreading to others
  • Avoid touching eyes, genitals
  • Possible referral to MD if infant is not drinking because of pain

**ACYCLOVIR NOT RECOMMENEDED ANYMORE

Medications:

  1. Topical anesthetic (OTC vs Rx)
  2. Mucosal coating (OTC)
  3. Analgesic (OTC vs Rx)
  4. Antiviral (Rx) (for immunocompromised or dehydrated pts)
19
Q

Warning about Primary HSV Meds

Study These Flashcards
A

Rinses may diminish the gag reflex therefore better suited for older patients, but remember serious side-effects of seizures and methemoglobinemia in pediatric population.

20
Q

HSV-1 Recurrent infection

Study These Flashcards
A 
Secondary herpes
Mild, self-limiting
Latency in trigeminal ganglion
Vermilion border
Intraorally on fixed keratinized mucosa
Prodrome> papules > vesicles > ulcer > crust > heals > no scar
7-10 days
Unilateral
21
Q

Recurrent HSV-Triggers

Study These Flashcards
A 
Old age
UV light
Physical/emotional stress
Fatigue
Heat 
Cold
Pregnancy
Allergy
Trauma
Dental treatment
Respiratory illnesses
Fever
Menstruation
Systemic Diseases
Malignancy
22
Q

Can you give someone Herpes if you’re asymptomatic?

Study These Flashcards
A

Asymptomatic shedding can occur in seropositive patients

More common after surgical procedures and in immunocompromised patients

Universal precautions

23
Q

What is the difference clinically between Recurrent HSV infection and Primary?

Study These Flashcards
A

Intraoral colescing lesions are NOT ON MOVABLE MUCOSA FOR RECURRENT!! (palate and keratinized gingiva)

24
Q

Recurrent HSV-Treatment

Study These Flashcards
A
  • Depends on severity/frequency
  • Preventive/suppressive vs episodic/abortive strategies
  • Antiviral agents/antiviral-steroid combination agents
  • Remove precipitating factors
25
Recurrent Herpes Labialis-FDA approved topical treatments
Rx: Acyclovir cream 5% (Zovirax) Disp: 5g tube Label: dab on lesion every 2 hours for 4 days Rx: Penciclovir cream 1% (Denavir) Disp: 5g tube Label: dab on lesion every 2 hours for 4 days Rx: Docosanal cream (Abreva) OTC Disp: 2g tube Label: dab on lesion five times per day for 4 days Rx: Acyclovir 5%/ hydrocortisone 1% cream (Xerese) Disp: 5g tube Label: dab on lesion 5 times a day for 5 days Rx: Acyclovir buccal tablets 50mg Disp: 2 dose pack Label: apply to canine fossa within 1 hour of symptoms (single dose)
26
Recurrent Herpes Labialis-FDA approved systemic antivirals
``` Rx: Valacyclovir 1g tablets Disp: 4 tabs Label: 2 tabs stat PO, then again in 12 hours (ie 2 doses) Rx: Famciclovir 500mg tablets Disp: 3 tabs Label: 3 tabs stat PO ```
27
Recurrent Herpes Labialis-OTHER Topical AGENTS
Ice L-lysine Bioflavonoids Evaporants-Dessicants Emollients Bioadhesives (Zilactin-benzyl alcohol, topical pain reliever) Wound-healing modification/occlusive agents
28
Suppression of Dentally Induced recurrent HSV
2-day prophylactic course of valacyclovir 1. 2g taken 1 hr before dental tx 2. 2g taken same evening 3. 1g taken bid the next day **STUDY WAS FUNDED BY MANUFACTURER OF VALTREX
29
HSV-ATYPICAL PRESENTATION
Immunocompromised host Location and extent of lesion *Usually do not see necrotic, large, lesions or lesions on movable mucosa*
30
HSV Associated Erythema multiforme
HSV implicated in trigger for erythema multiforme Skin immune reaction in response to infection Rx antiviral prophylaxis
31
Varicella Zoster Virus Infection
- HHV3 - Primary infection is Varicella/Chicken pox - Secondary infection is Zoster/Shingles - May affect oral cavity/face if reactivation along distribution of V1/2/3
32
Cytomegalovirus Infection
-HHV-5 -Latency in myeloid cells, salivary gland cells and endothelium ("OWL EYES") -Disease states found predominantly in: > pregnancy/neonates (congenital infection) > immunocompromised patients, particularly transplant and HIV+ patients
33
Epstein-Barr Virus Infection
- HHV-4 - Latency in lymphocytes ``` -EBV-induced diseases with oral manifestations: > Infectious mononucleosis > Oral hairy leukoplakia >Nasopharyngeal carcinoma >EBV mucocutaneous ulceration > Burkitt lymphoma ``` Burkitt lymphoma histology is Sheets of diffuse B cells "starry sky" is lymphocytes with center of macrophage
34
Kaposi sarcoma
-HHV-8, KSHV -Vascular neoplasm of endothelium -Associated with immunosuppression -Usually evolves through 3 stages: Patch-plaque-nodular DOES NOT BLANCH ON PALPATION

OMPR (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions