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Flashcards in HTN Drugs Deck (16)
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1

Pregnancy
Good (3) and Bad (2) Drugs To Use

Safe:
Hydralazine (emergency)
Nifedipine (emergency)
alpha-Methyldopa (gestational HTN)

ACE Inhibitors
ARBs

2

First Line Drugs For HTN
Class and Examples (4)

Calcium Channel Blockers

Dihydropyridines:
Nifedipine
Amlodipine

Non-Dihydropyridines:
Diltiazem
Verapamil

3

Dihydropyridines
Effects (2) and Adverse Effects (5)

Coronary vasodilation
Peripheral vasodilation

Flushing
Edema
Headache
Palpitations
Gingival Hyperplasia

4

Non-Dihydropyridines
Effects (3), Adverse Effects (4) and Dosing Notes (2)

Coronary vasodilation
Negative inotropy and contractility

Headache
Gingival hyperplasia
Constipation
Bradycardia

Oral delivery
Frequency dependent on effects (cardioactive)

5

ACE Inhibitors
MOA (3), Uses (3), Adverse Effects (2) and Contraindications (2)

Blocks AGTII conversion which causes:
Decreased vasoconstriction and vascular remodeling
Decreases aldosterone which decreases BP

Maintenance of HTN, HTN emergencies and Heart Failure

Bradykinin cough
Angioedema (emergency if tongue swells)

Pregnancy
Bilateral renal stenosis (can cause renal failure)

6

Angiotensin Receptor Blockers (ARBs)
MOA (4) and Adverse Effects (4)

Block AGTII receptor
Decreases vasoconstriction, remodeling and BP

Orthostatic Hypotension
Hypoglycemia
Hyperkalemia
*Adverse more common in diabetics

7

RAAS Inhibitors Main Use and Class Examples
ACEI (4), ARB (3) and Renin Blocker (1)

Captopril
Enalopril
Benzapril
Lisinopril

Losartan
Valsartan
Candesartan

Aliskiren

Especially useful for Renal HTN in unilateral Renal A stenosis

8

Sympatholytic Agents
Classes (3) and Important Warning

alpha1 Antagonists
alpha2 Antagonists
beta-Blockers

Can't abruptly stop using due to deadly Rebound HTN

9

Phentolamine and Phenoxybenzamine
Drug Class, Effect and Side Effects (3)

alpha-1 Antagonist

Vasodilation

Hypotensive episodes
Orthostatic hypotension
Reflex tachycardia

10

alpha-2 Receptor Antagonists
MOA (5)

Locally increases BP

Travels to CNS and decreases SNS output which:
Decreases peripheral resistance
Decreases renal resistant
Decreases HR and BP

11

alpha-2 Receptor Antagonists
Examples (2) with Adverse Effects (3/2)

Clonidine
Rebound HTN, Xerostomia, Drowsiness

alpa-Methyldopa
Thrombocytopenia, SLE-like Syndrome

12

Beta-1 and Beta-2 Blockers
Effects (2 each) and Examples (Selective and Non)

Beta-1: Decreases HR and BP
Beta-2: Bronchoconstricts and Vasoconstricts

Beta-1 Selective:
Bisoprolol, Metoprolol and Atenolol

Non-Selective:
Propranolol

13

Propranolol
Adverse Effect and Contraindication

Cold Extremities
Peripheral Vascular Disease

14

Hydralazine
Effect, Uses (2), Main Side Effect

Direct arteriolar dilation

Used in hypertensive emergency in pregnancy
Used in reduced EF heart failure

Drug Induced SLE-like Syndrome

15

Nitroprusside
Effects (2) and Danger

Venule and Arteriole dilation

Thiocyanate poisoning

16

Minoxidil
Effects (2) and Side Effect

Arteriolar dilation
Hair growth

Pericardial effusion