Asthma Pharmacology Flashcards Preview

CPR II Block 2 > Asthma Pharmacology > Flashcards

Flashcards in Asthma Pharmacology Deck (19)
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1

Short Acting Beta Agonists (5)

Albuterol
Terbutaline
Metaproterenol
Pirbuterol
Levalbuterol

2

Long Acting Beta Agonists (5)

Formoterol
Salmeterol
Indacaterol
Vilanterol
Olodaterol

3

Anticholinergic Drugs (4)

Atropine
Ipratropium
Tiotropium
Aclidinium

4

Theophylline
Drug Class and Actions (2), MOA, Contraindications (3)

Methylxanthine

Bronchodilation
Prophylactic suppression of airway stimuli

PDE5 Inhibitor

Peptic Ulcers
Seizures
Cardiac Arrhythmias

5

Inhaled Corticosteroids (7)

Beclomethasone
Budesonide
Ciclesonide
Flunisolide
Fluticasone
Mometasone
Triamcinolone

6

Prednisone
Class, MOA, Indication, Cautions (2)

Oral corticosteroids

Decreases transcription of inflammatory genes

1st line for persistent asthma

Cushing's Syndrome
Hyperglycemia

7

Montelukast
MOA, Indications (2) and Limitation

Blocks CysLT1 receptors to inhibit LTD4

Treats allergies and prevents asthma attacks

Oral delivery so not used for reversal of acute bronchospasm

8

Zafirlukast
MOA, Indication and Complication

Blocks CysLT1 to inhibit LTD4/LTE4

Prophylactic treatment of chronic asthma

Hepatotoxic

9

Zileuton
MOA, Indication and Caution

LOX inhibitor that blocks LTB4/LTC4/LTD4/LTE4

Prophylactic treatment of chronic asthma

Not recommended in liver disease with enzymes 3x the normal limit

10

Omalizumab
MOA, Indications (2) and Caution

Monoclonal Ab to IgE

Used for moderate-severe asthma with positive allergen testing
Chronic idiopathic urticaria

Can cause Anaphylaxis

11

Asthma/COPD Crossover Triple Therapy

Long acting beta agonist
Long acting muscarinic antagonist
Inhaled corticosteroid

12

SABA
Indications (4), Adverse (3)

Acute bronchospasm
COPD Exacerbation
Bronchitis
Bronchiolitis

Paradoxical bronchospasm
Tachycardia
Heart Palpitations

13

Terbutaline Unique Characteristics (2)

Only injectable SABA (subcutaneous)
Sulfa drug

14

LABA
Use (2) and Adverse Effects (2)

Long term maintenance of asthma/COPD
Used concomitantly with other long term drugs (ICS)

Increased risk of asthma death and hospitalization

15

Muscarinic Antagonists
Uses (2)

Asthma/COPD maintenance
(Ipratropium, Tiotropium and Aclidinium)

Atropine only for life threatening muscarinic situations
(only 2-3 mg in Coronary A DZ patients)

16

Inhaled Corticosteroids
MOA (2), Uses (3), Contraindications

Decreases transcription of inflammatory genes
Most effective anti-inflammatory asthma controllers

Exercise induced asthma
1st line for persistent asthma
Prevention of airway remodeling

Status asthmaticus
Acute bronchospasm

17

Corticosteroids Associated with Adrenal Insufficiency (3)

Prednisone
Beclomethasone
Triamcinolone

18

Coritcosteroids Associated with Candida Infections (2)

Fluticasone
Ciclesonide

19

ICS + LABA Combination Inhalers (3)

Fluticasone + Salmeterol

Mometasone + Formoterol

Budesonide + Formoterol