Flashcards in Asthma Pharmacology Deck (19)
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1
Short Acting Beta Agonists (5)
Albuterol
Terbutaline
Metaproterenol
Pirbuterol
Levalbuterol
2
Long Acting Beta Agonists (5)
Formoterol
Salmeterol
Indacaterol
Vilanterol
Olodaterol
3
Anticholinergic Drugs (4)
Atropine
Ipratropium
Tiotropium
Aclidinium
4
Theophylline
Drug Class and Actions (2), MOA, Contraindications (3)
Methylxanthine
Bronchodilation
Prophylactic suppression of airway stimuli
PDE5 Inhibitor
Peptic Ulcers
Seizures
Cardiac Arrhythmias
5
Inhaled Corticosteroids (7)
Beclomethasone
Budesonide
Ciclesonide
Flunisolide
Fluticasone
Mometasone
Triamcinolone
6
Prednisone
Class, MOA, Indication, Cautions (2)
Oral corticosteroids
Decreases transcription of inflammatory genes
1st line for persistent asthma
Cushing's Syndrome
Hyperglycemia
7
Montelukast
MOA, Indications (2) and Limitation
Blocks CysLT1 receptors to inhibit LTD4
Treats allergies and prevents asthma attacks
Oral delivery so not used for reversal of acute bronchospasm
8
Zafirlukast
MOA, Indication and Complication
Blocks CysLT1 to inhibit LTD4/LTE4
Prophylactic treatment of chronic asthma
Hepatotoxic
9
Zileuton
MOA, Indication and Caution
LOX inhibitor that blocks LTB4/LTC4/LTD4/LTE4
Prophylactic treatment of chronic asthma
Not recommended in liver disease with enzymes 3x the normal limit
10
Omalizumab
MOA, Indications (2) and Caution
Monoclonal Ab to IgE
Used for moderate-severe asthma with positive allergen testing
Chronic idiopathic urticaria
Can cause Anaphylaxis
11
Asthma/COPD Crossover Triple Therapy
Long acting beta agonist
Long acting muscarinic antagonist
Inhaled corticosteroid
12
SABA
Indications (4), Adverse (3)
Acute bronchospasm
COPD Exacerbation
Bronchitis
Bronchiolitis
Paradoxical bronchospasm
Tachycardia
Heart Palpitations
13
Terbutaline Unique Characteristics (2)
Only injectable SABA (subcutaneous)
Sulfa drug
14
LABA
Use (2) and Adverse Effects (2)
Long term maintenance of asthma/COPD
Used concomitantly with other long term drugs (ICS)
Increased risk of asthma death and hospitalization
15
Muscarinic Antagonists
Uses (2)
Asthma/COPD maintenance
(Ipratropium, Tiotropium and Aclidinium)
Atropine only for life threatening muscarinic situations
(only 2-3 mg in Coronary A DZ patients)
16
Inhaled Corticosteroids
MOA (2), Uses (3), Contraindications
Decreases transcription of inflammatory genes
Most effective anti-inflammatory asthma controllers
Exercise induced asthma
1st line for persistent asthma
Prevention of airway remodeling
Status asthmaticus
Acute bronchospasm
17
Corticosteroids Associated with Adrenal Insufficiency (3)
Prednisone
Beclomethasone
Triamcinolone
18
Coritcosteroids Associated with Candida Infections (2)
Fluticasone
Ciclesonide
19