Asthma Pharmacology Flashcards Preview

Question 1

1

Short Acting Beta Agonists (5)

Answer

Albuterol
Terbutaline
Metaproterenol
Pirbuterol
Levalbuterol

Question 2

2

Long Acting Beta Agonists (5)

Answer

Formoterol
Salmeterol
Indacaterol
Vilanterol
Olodaterol

Question 3

3

Anticholinergic Drugs (4)

Answer

Atropine
Ipratropium
Tiotropium
Aclidinium

Question 4

4

Theophylline
Drug Class and Actions (2), MOA, Contraindications (3)

Answer

Methylxanthine

Bronchodilation
Prophylactic suppression of airway stimuli

PDE5 Inhibitor

Peptic Ulcers
Seizures
Cardiac Arrhythmias

Question 5

5

Inhaled Corticosteroids (7)

Answer

Beclomethasone
Budesonide
Ciclesonide
Flunisolide
Fluticasone
Mometasone
Triamcinolone

Question 6

6

Prednisone
Class, MOA, Indication, Cautions (2)

Answer

Oral corticosteroids

Decreases transcription of inflammatory genes

1st line for persistent asthma

Cushing's Syndrome
Hyperglycemia

Question 7

7

Montelukast
MOA, Indications (2) and Limitation

Answer

Blocks CysLT1 receptors to inhibit LTD4

Treats allergies and prevents asthma attacks

Oral delivery so not used for reversal of acute bronchospasm

Question 8

8

Zafirlukast
MOA, Indication and Complication

Answer

Blocks CysLT1 to inhibit LTD4/LTE4

Prophylactic treatment of chronic asthma

Hepatotoxic

Question 9

9

Zileuton
MOA, Indication and Caution

Answer

LOX inhibitor that blocks LTB4/LTC4/LTD4/LTE4

Prophylactic treatment of chronic asthma

Not recommended in liver disease with enzymes 3x the normal limit

Question 10

10

Omalizumab
MOA, Indications (2) and Caution

Answer

Monoclonal Ab to IgE

Used for moderate-severe asthma with positive allergen testing
Chronic idiopathic urticaria

Can cause Anaphylaxis

Question 11

11

Asthma/COPD Crossover Triple Therapy

Answer

Long acting beta agonist
Long acting muscarinic antagonist
Inhaled corticosteroid

Question 12

12

SABA
Indications (4), Adverse (3)

Answer

Acute bronchospasm
COPD Exacerbation
Bronchitis
Bronchiolitis

Paradoxical bronchospasm
Tachycardia
Heart Palpitations

Question 13

13

Terbutaline Unique Characteristics (2)

Answer

Only injectable SABA (subcutaneous)
Sulfa drug

Question 14

14

LABA
Use (2) and Adverse Effects (2)

Answer

Long term maintenance of asthma/COPD
Used concomitantly with other long term drugs (ICS)

Increased risk of asthma death and hospitalization

Question 15

15

Muscarinic Antagonists
Uses (2)

Answer

Asthma/COPD maintenance
(Ipratropium, Tiotropium and Aclidinium)

Atropine only for life threatening muscarinic situations
(only 2-3 mg in Coronary A DZ patients)

Question 16

16

Inhaled Corticosteroids
MOA (2), Uses (3), Contraindications

Answer

Decreases transcription of inflammatory genes
Most effective anti-inflammatory asthma controllers

Exercise induced asthma
1st line for persistent asthma
Prevention of airway remodeling

Status asthmaticus
Acute bronchospasm

Question 17

17

Corticosteroids Associated with Adrenal Insufficiency (3)

Answer

Prednisone
Beclomethasone
Triamcinolone

Question 18

18

Coritcosteroids Associated with Candida Infections (2)

Answer

Fluticasone
Ciclesonide

Question 19

19

ICS + LABA Combination Inhalers (3)

Answer

Fluticasone + Salmeterol

Mometasone + Formoterol

Budesonide + Formoterol

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Asthma Pharmacology Flashcards Preview

CPR II Block 2 > Asthma Pharmacology > Flashcards

Short Acting Beta Agonists (5)

AlbuterolTerbutalineMetaproterenolPirbuterolLevalbuterol

Long Acting Beta Agonists (5)

FormoterolSalmeterolIndacaterolVilanterolOlodaterol

Anticholinergic Drugs (4)

AtropineIpratropiumTiotropiumAclidinium

TheophyllineDrug Class and Actions (2), MOA, Contraindications (3)

MethylxanthineBronchodilationProphylactic suppression of airway stimuliPDE5 InhibitorPeptic UlcersSeizuresCardiac Arrhythmias

Inhaled Corticosteroids (7)

BeclomethasoneBudesonideCiclesonideFlunisolideFluticasoneMometasoneTriamcinolone

PrednisoneClass, MOA, Indication, Cautions (2)

Oral corticosteroidsDecreases transcription of inflammatory genes1st line for persistent asthmaCushing's SyndromeHyperglycemia

MontelukastMOA, Indications (2) and Limitation

Blocks CysLT1 receptors to inhibit LTD4Treats allergies and prevents asthma attacksOral delivery so not used for reversal of acute bronchospasm

ZafirlukastMOA, Indication and Complication

Blocks CysLT1 to inhibit LTD4/LTE4Prophylactic treatment of chronic asthmaHepatotoxic

ZileutonMOA, Indication and Caution

LOX inhibitor that blocks LTB4/LTC4/LTD4/LTE4Prophylactic treatment of chronic asthmaNot recommended in liver disease with enzymes 3x the normal limit

OmalizumabMOA, Indications (2) and Caution

Monoclonal Ab to IgEUsed for moderate-severe asthma with positive allergen testingChronic idiopathic urticariaCan cause Anaphylaxis

Asthma/COPD Crossover Triple Therapy

Long acting beta agonistLong acting muscarinic antagonistInhaled corticosteroid

SABAIndications (4), Adverse (3)

Acute bronchospasmCOPD ExacerbationBronchitisBronchiolitisParadoxical bronchospasmTachycardiaHeart Palpitations

Terbutaline Unique Characteristics (2)

Only injectable SABA (subcutaneous)Sulfa drug

LABAUse (2) and Adverse Effects (2)

Long term maintenance of asthma/COPDUsed concomitantly with other long term drugs (ICS)Increased risk of asthma death and hospitalization

Muscarinic AntagonistsUses (2)

Asthma/COPD maintenance (Ipratropium, Tiotropium and Aclidinium)Atropine only for life threatening muscarinic situations(only 2-3 mg in Coronary A DZ patients)

Inhaled CorticosteroidsMOA (2), Uses (3), Contraindications

Decreases transcription of inflammatory genesMost effective anti-inflammatory asthma controllersExercise induced asthma1st line for persistent asthmaPrevention of airway remodelingStatus asthmaticusAcute bronchospasm