HTN intro Flashcards

(46 cards)

1
Q

Who is at risk for HTN?

A
  • Elderly
  • Blacks
  • Pregnancy
  • Teens now emerging (problem)
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2
Q

What are the factors for HTN?

A
  • Obesity
  • Lack of physical activity
  • Too much salt in our diet
  • Older age
  • Family history of hypertension
  • Chronic kidney disease
  • Too much alcohol consumption
  • Insufficient intake of potassium, magnesium and calcium
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3
Q

What is BP?

A

Cardiac Output x Peripheral Resistance

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4
Q

What is normal BP?

By the JNC-7

A

Systolic (mm Hg) = Less than 120
AND
Diastolic (mm Hg) = Less than 80

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5
Q

What is Prehypertension?
(By the JNC-7)

  • What do you do for Prehypertension?
A

Systolic (mm Hg) = 120-139
OR
Diastolic (mm Hg) = 80-89

  • No drug therapy, only lifestyle modifications
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6
Q

What is Stage 1 HTN?

By the JNC-7

A

Systolic (mm Hg) = 140-159
OR
Diastolic (mm Hg) = 90-99

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7
Q

What is Stage 2 HTN?

By the JNC-7

A

Systolic (mm Hg) = 160 or greater
OR
Diastolic (mm Hg) = 100 or greater

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8
Q

What are compelling Indications in HTN?

A

Uncontrolled Diabetes, MI, stroke, other cormorbidities etc.

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9
Q

What is the first thing you should do? (According to JNC-7)

A

lifestyle modifications

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10
Q

If not goal BP, after lifestyle modifications, what do you do if patient has no compelling indications? (According to JNC-7)

A

1.) Stage 1 Hypertension?
Thiazide-Type Diuretic for most.
May consider ACEI, ARB, Beta-blocker, CCB or
combination

2.) Stage 2 Hypertension?
2 drug combination for most.
(Usually thiazide and ACEI or ARB or beta-blocker
or CCB)

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11
Q

If not goal BP, after lifestyle modifications, what do you do if patient DOES HAVE compelling indications? (According to JNC-7)

A

Drug(s) for the Compelling Indications.

Other antihypertensive drugs (diuretics, ACEI, ARB, beta-blockers, CCB as needed

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12
Q

If not goal BP, after first drug interventions what do you do ? (According to JNC-7)

A
  • Optimize Dosages or Add Additional Drugs Until Goal BP is Achieved.
  • Consider Consultation with Hypertension Specialist (when on 2-3 drugs)
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13
Q

What is the goal BP?

A

< 140

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14
Q

What MUST be done for the antihypertensive drugs to be effective?

A

Must be used while doing lifestyle modifications!

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15
Q

According to the ESH ‘13 what are the risk factors for HTN?

A
  • Male
  • Smoker
  • Age (men 55 and older, women 65 and older)
  • Dyslipidemia
  • Fasting plasma glucose (102- 125 mg/dL)
  • Abnormal glucose tolerance test
  • Obesity (BMI 30 kg/m2 or greater)
  • Abdominal obesity (waist circumference men 102 cm or more; women 88 cm or more*)
  • Family history of premature cardiovascular disease (men ages less than 55 years; women aged less than 65 years)
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16
Q

What does ESH ‘13 define as Dyslipidemia

A
  • Total cholesterol greater than 190 mg/dL and/or
  • Low-density lipoprotein cholesterol greater than 115 mg/dL and/or
  • High-density lipoprotein cholesterol: men less than 40 mg/dL, women less than 46 mg/dL and/or
  • Triglycerides greater than 150 mg/dL
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17
Q
  1. ) What is the optimal BP?
  2. ) What is the normal BP?
  3. ) What is the High normal BP?

(According to the ESH’13)

A
  1. ) Less than 120/Less than 80
  2. ) 120-129/80-84
  3. ) 130-139/85-89
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18
Q

What is Grade 1 HTN?

According to the ESH’13

A

140-159/90-99

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19
Q

What is Grade 2 HTN?

According to the ESH’13

A

160-179/100-109

20
Q

What is Grade 3 HTN?

According to the ESH’13

A

180 or greater/110 or greater

21
Q

What is Isolated Systolic HTN?

According to the ESH’13

A

140 or greater/Less than 90

22
Q

What do you do for High Normal BP with NO risk factors?

According to the ESH’13

A

No BP intervention

23
Q

What do you do for High Normal BP with risk factors?

According to the ESH’13

A
  • Lifestyle changes

- No BP intervention

24
Q

What do you do for Grade 1 HTN or Grade 2 HTN with no Risk factors?
(According to the ESH’13)

A
  • Lifestyle changes for several months

- Then add BP drugs targeting <140/90

25
What do you do for Grade 1 HTN with risk factors or Grade 2 HTN with 1-2 risk factors? (According to the ESH'13)
- Lifestyle changes for several weeks | - Then add BP drugs targeting <140/90
26
What do you do for Grade 2 HTN with 3 or more risk factors? | According to the ESH'13
- Lifestyle changes | - BP drugs targeting <140/90
27
What do you do for Grade 3 HTN? | According to the ESH'13
- Lifestyle changes | - Immediate BP drugs targeting <140/90
28
What do you do for High Normal BP AND Organ damage, chronic kidney disease stage 3 or diabetes OR Symptomatic CVD, CKD stage 4 or greater or diabetes with OD/RFs? (According to the ESH'13)
- Life style changes | - No BP intervention
29
What do you do for Grade 1 HTN or Grade 2 HTN AND Organ damage, chronic kidney disease stage 3 or diabetes OR Symptomatic CVD, CKD stage 4 or greater or diabetes with OD/RFs? (According to the ESH'13)
- Lifestyle changes | - BP drugs targeting
30
What do you do for Grade 3 HTN AND Organ damage, chronic kidney disease stage 3 or diabetes OR Symptomatic CVD, CKD stage 4 or greater or diabetes with OD/RFs? (According to the ESH'13)
- Lifestyle changes | - Immediate BP drugs targeting <140/90
31
What are Lifestyle modifications?
- Weight reduction - Sodium restriction - Reduced alcohol intake - Stop smoking - Reduce dietary saturated fats and cholesterol - Maintain adequate potassium, calcium, magnesium - Reduce stress
32
What meds do African Americans respond better to?
Better response to calcium channel blockers and diuretics compared with beta blockers, ACEI or ARB monotherapy
33
What is a good med for Pregnancy?
- *methyldopa*, beta blocker, and vasodilators | - Avoid ACE inhibitors and angiotensin receptor blockers
34
What are the contraindications of Diuretics?
- Possible contraindications: Dyslipidemia, diabetes* | - Compelling contraindications: Gout, allergy to sulfa-based diuretics
35
What are the contraindications of Beta Blockers?
- Possible contraindications: Asthma, COPD, dyslipidemia, severe peripheral vascular disease - Compelling contraindications: Bronchospastic disease, second or third-degree heart block
36
What are the contraindications of ACEI or ARBs?
- Possible contraindications: *Bilateral* renal artery stenosis, renal insufficiency - Compelling contraindications:Pregnancy, hyperkalemia
37
What are the contraindications of Calcium channel blockers?
- Possible contraindications: none | - Compelling contraindications: Second or third-degree heart block, heart failure
38
What are the contraindications of Alpha blockers?
- Possible contraindications: Postural hypotension | - Compelling contraindications: Urinary incontinence
39
When does the JNC 7 suggest that a two drug regimen is appropriate to use at initiation?
- Blood pressure more than 20 mm Hg systolic or 10 mm Hg systolic (DIASTOLIC?) above the treatment goal - A two-drug regimen would include a diuretic
40
When is caution urged for using combination BP meds at initiation?
- Elderly patients | - Combinations mask if one agent would have been sufficient
41
What is HEXAMETHONIUM?
- Block the action of acetylcholine at nicotinic receptors at sympathetic and parasympathetic autonomic ganglia --> Good or bad? - Reduce arteriolar and venomotor tone
42
What are side effects of HEXAMETHONIUM?
- It looks like neuro-muscular blocker so it can paralyze the muscles of respiration - Urinary retention - Tachcardya - Blocks everything on parasympathetic and sympathetic side
43
What is Reserpine?
- Neurotransmitter reuptake blockade: Norepinephrine, Dopamine, Serotonin - Irreversible effect
44
What are the adverse drug reactions of Reserpine?
- Central nervous system: Sedation, depression, nightmares, suicide - Extrapyramidal effects, e.g. tremor
45
What is Guanethidine?
- Norepinephrine release inhibition: Gradual depletion of norepinephrine in nerve endings - Drug-drug interactions - Can't prescribe it anymore
46
What are the adverse drug reactions of Guanethidine?
Hypotension; postural and post-exercise