Human Reproductive Physiology and Reproductive Cycles lecture 6 Flashcards

(75 cards)

1
Q

Sperm production takes place in the ____________. Each testis contains ~500 coiled tubules called ________________ – that produce hundreds (thousands?) of sperm each second in healthy males.

A

1) testes
2) SEMINIFEROUS TUBULES

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2
Q

The inner lining of each tubule is lined with germinal tissue ( germinal means it’s gonna create something) – germinal tissue includes two kinds of cells knowns as

1)

2)

A

1) Germ cells
2) SUSTENTACULAR (Sertoli or Nurse) CELLS

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3
Q

•GERM CELLS goes through _________, these cells produce haploid sperm cells. All four resultant cells are viable sperm cells.

A

1) meiosis

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4
Q

•SUSTENTACULAR (Sertoli or Nurse) CELLS – nourish and __________________. They also secrete lubricating fluid to aid outward movement of sperm as they exit testis via ______________ and eventually epididymis. Also produces AMH (__________________), which regulates other hormones (e.g. testosterone, estradiol)

A

1) protect germ cells (so they can undergo meiosis)
2) efferent ductules
3) anti-Mullerian hormone

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5
Q

After it’s secreted by the sustentacular cells, the _______________ causes the “regression تراجع” of the paramesonephric duct.

A

anti-Mullerian hormone

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6
Q

Between seminiferous tubules there are clusters of endocrine cells called ____________ (aka ‘LEYDIG’) CELLS.

A

INTERSTITIAL

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7
Q

These cells secrete male sex hormones – ANDROGENS, the most important of which is __________________.

A

TESTOSTERONE

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8
Q

Sperm cells are amongst the smallest in the body (~1/20 mm).
Simple construction: __________________.
Tail is a flagellum – whipping motion provides ____________.
Base of tail contains a coiled _______________ to provide power for movement.

A

1) head and tail
2) motility
3) mitochondrion

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9
Q

Sperm Head contains nucleus and an organelle called an _____________ which contains digestive enzymes that helps sperm to penetrate egg (if present).

A

1)ACROSOME (a combination of vesicles diffused together)

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10
Q

Seminiferous tubules lead into straight tubules, then into larger set of tubules called _______________.

A

RETE TESTIS

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11
Q

Rete testis ultimately drains into larger tubules called ______________, which in turn drain into ____________.

A

1) efferent ductules
2) EPIDIDYMIS

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12
Q

Epididymis includes _________, ________ , and TAIL.
Tail of epididymis dilates (expands) into _______________.

A

1) HEAD
2) BODY
3) DUCTUS DEFERENS

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13
Q

Epididymis is a site of __________ storage

A

sperm (it’s not motile)

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14
Q

Epididimis secretes an enzyme that ___________________ of sperm that it can’t move.

A

Prevents the capacitence

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15
Q

DUCTUS DEFERENS passes up spermatic cord, and into body through _______________.
Inside body, right and left ductus deferens pass __________ over ureters, then loops _________ to them behind the urinary bladder.

A

1) inguinal canal
2) cranially
3) dorsal

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16
Q

As each duct passes behind (dorsal to) bladder, it has appended to it a gland called the ________________.

A

SEMINAL VESICLE

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17
Q

Just prior to attachment of the seminal vesicle, the ductus enlarges into an ________, which is a position of sperm storage prior to ejaculation.

A

AMPULLA

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18
Q

Notice how the spermatic cord loops ventral to (“in front of”) the attachment of the ureter of the bladder.

A
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19
Q

SEMINAL VESICLE has the enzyme which causes ______________ of the sperm

A

the capacitence

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20
Q

SEMINAL VESICLE

  • Plastered up against the dorsal side of ____________.
  • Exocrine glands - provide secretions that make up most of _____________.
  • Fluid lubricates path of exiting sperm.
  • Fluid is energy-rich (sugar rich) , providing food for sperm which is called _________.
A

1) urinary bladder
2) seminal fluid
3) Fructose

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21
Q

SEMINAL VESICLE Secretions is slightly __________. it helps to neutralize slightly acidic environment of vagina.

A

alkaline

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22
Q

_______________ promotes uterine contractions to help facilitate sperm movement up uterus into fallopian tubes.
___________ forms a temporary clot in vagina.

Once beyond the seminal vesicle, ductus is referred to as the ejaculatory duct. These are paired structures which empty into the prostatic urethra.

A

1) PROSTAGLANDINS
2) Fibrinogen

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23
Q
  • Ejaculatory ducts come together to join the urethra within the mass of the ____________.
  • Prostate is a single, midline gland just ________ to urinary bladder.
  • Prostate is a mass of ____________, glandular tissue, and _____________.
A

1) prostate gland
2) inferior
3) connective tissue
4) smooth muscle

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24
Q

Prostate gland secretes Prostatic fluid that acts on the _____________ that is inside the seminal fluid that causes the clot in Females Vagina, after the temporery Clotting enzyme, the ____________ will break the clot down.

A

1) Fibrinogen
2) profibrinolysin

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25
BULBOURETHRAL GLANDS is located in the \_\_\_\_\_\_\_\_\_\_\_\_\_\_.
Cranial body wall
26
BULBOURETHRAL GLANDS is a Pair of glands at the base of prostate. it Secrets _____________ (pre-ejaculatory fluid that Lubricates the urethra & glans of penis.
Alkaline mucus
27
ERECTION ## Footnote * Primarily a PARASYMPATHETIC function segments \_\_\_\_\_\_\_\_\_\_ * Parasympathetic function stimulates dilation of penile blood vessels – causing __________ of penis with blood. (A muscular hydrostat). Parasympathetic action potentials also stimulate glands to _____________ (e.g., bulbourethral).
1) sacral outflow (S2, S3, S4) (Autonomic control) 2) engorgement 3) secrete fluids
28
* An erection is Initiated by sensory stimuli, including sensations conveyed via \_\_\_\_\_\_\_\_\_\_\_\_\_ * Conscious thoughts (cerebral cortex) can either ________________ erection center in hypothalamus. * Also in part a sacral reflex (spinal cord injuries do not preclude sexual activity)
1) pudendal nerves 2) stimulate or inhibit
29
EJACULATION ## Footnote * A ____________ FUNCTION!! * Sympathetic fibers innervate smooth muscle of \_\_\_\_\_\_\_\_\_\_\_\_. * Produces forceful ____________ contractions of smooth muscle of ductus deferens. * Peristalsis _________ sperm and seminal fluid out distal end of urethra.
1) SYMPATHETIC 2) ductus deferens 3) peristaltic 4) propels
30
GONADOTROPIN **RELEASING HORMONE** (GnRH) – (hypothalamus) stimulates secretion of _________________ and \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ from ant. pituitary .
1) Follicle Stimulating Hormone (FSH) 2) Luteinizing Hormone (LH)
31
FOLLICLE STIMULATING HORMONE (FSH) and LUTEINIZING HORMONE (LH) are both produced by anterior pituitary and are Responsible for stimulating ____________ and ___________ secretion.
1) spermatogenesis 2) testosterone
32
TESTOSERONE – stimulates development of male sex organs, as well as secondary sexual characteristics. Participates in feedback loop involving \_\_\_\_\_\_\_\_\_. Also inhibits secretion of \_\_\_.
1) GONADOTROPIN RELEASING HORMONE (GnRH) 2) LH
33
INHIBIN – secreted by __________ cells, in response to sperm production. Inhibits secretion of \_\_\_\_\_.
1) sustentacular 2) FSH
34
Hypothalamus passes down to the Anterior Pituitary Gland through the \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_.
Pituitary portal system.
35
VERY IMPORTANT
36
those three makes up the??????? •Mesovarium •Mesosalpinx •Mesometrium
BROAD LIGAMENT
37
MEIOSIS IN FEMALES ## Footnote * (Recall that in males, each germinal cell produces four haploid cells – each of which becomes a viable sperm cell.) * In females, only ______ of the resulting cells will be viable and the other ______ degenerate.
1) one 2) Three
38
Before first meiotic division in females, each germinal cell remains in suspended development. That is called \_\_\_\_\_\_\_\_\_\_\_\_\_(diploid).
PRIMARY OOCYTE
39
1st meiotic division is not completed until puberty, when ________________ cycle.
FSH triggers ovarian
40
After 1st meiotic division, the remaining largest cell is the ________________ (haploid).
SECONDARY OOCYTE
41
2nd meiotic division is not completed until _________________ (haploid).
thta oocyte is fertilized
42
Each primary oocyte is packaged in an epithelial vesicle called a \_\_\_\_\_\_\_\_\_\_\_.
FOLLICLE
43
It is within a follicle that the 1st meiotic division is completed to create \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_.
secondary oocyte
44
Ovarian cycle has 2 basic stages which are 1) \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ 2) \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
1) Follicular phase (preovulatory phase) 2) Luteal phase (postovulatory phase)
45
Follicular phase (preovulatory phase) – _________________ of primary oocyte into secondary oocyte within follicle. Release of \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_.
1) development and maturation
46
Luteal phase (postovulatory phase) – degeneration of empty __________ and preparation of uterus for \_\_\_\_\_\_\_\_\_\_\_.
1) follicle 2) pregnancy
47
what are the steps for Follicular phase ?
PRIMORDIAL FOLLICLE ----\> PRIMARY FOLLICLE ----\> SECONDARY FOLLICLE ----\> TERTIARY FOLLICLE (VESICULAR OVARIAN FOLLICLE, GRAFFIAN FOLLICLE)
48
PRIMORDIAL FOLLICLE – not yet \_\_\_\_\_\_\_\_\_\_\_\_. PRIMARY FOLLICLE – develops _________ & thecal cells and zona \_\_\_\_\_\_\_\_\_ SECONDARY FOLLICLE – follicular fluid develops between ______ and ________ layers of follicle
1) growing 2) granulosa 3) pellucida 4) inner & outer
49
TERTIARY FOLLICLE (VESICULAR OVARIAN FOLLICLE, GRAFFIAN FOLLICLE) – fluid fills the \_\_\_\_\_\_\_\_\_, and primary oocyte matures into secondary oocyte, almost \_\_\_\_\_\_\_\_\_\_\_\_\_.
1) antrum 2) ready to be released
50
what are the steps for Luteal phase?
CORPUS LUTEUM ----\> CORPUS ALBICANS
51
CORPUS LUTEUM – what is left of follicle after \_\_\_\_\_\_\_\_. Corpus luteum secretes some _________ and mostly \_\_\_\_\_\_\_\_\_\_, both of which are important in regulating female menstrual cycle. •CORPUS ALBICANS – degenerated \_\_\_\_\_\_\_\_\_\_.
1) ovulation 2) ESTROGEN 3) PROGESTERONE 4) follicle
52
•\_\_\_\_\_\_\_\_\_\_\_\_ is the release of a secondary oocyte from a mature follicle. •Occurs in response to high concentrations of \_\_\_\_\_\_\_\_\_\_, primarily LH. •Secondary oocyte is “\_\_\_\_\_\_\_\_\_” from ovary directly through mass of ovarian wall. Fimbria directs oocyte into \_\_\_\_\_\_\_\_\_\_\_\_\_\_, preventing movement into coelom.
1) OVULATION 2) Gonadotropins 3) ejected 4) fallopian tube
53
VERY IMPORTANT SO AFTER MASTERING THE OTHER CARD COME BACK AND MAKE CONNECTION
54
Hypothalamus releases GnRH that acts on the adenohypophysis and makes it produce and secrete \_\_\_\_\_\_\_\_\_\_\_\_
FSH & LH
55
The target of FSH in the female is to produce \_\_\_\_\_\_\_\_\_\_\_\_\_\_, which has two functions. LIST THEM * Release \_\_\_\_\_\_\_\_\_\_\_\_ * THey start to mature, which will cause the \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
1) granulosa cells 2) granulosa cells 2) OOCYTE to mature and develope
56
what happens at the luteal phase? the uterine cycle shows the endometrium which is the
1) the hormone secreted changes 2) inner linning of the uterus
57
FSH levels are higher than LH levels from day 0-14 to \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
stimulate the development
58
Bleeding the first day on your period represent the ___________________________ if and only if there is no pregnancy.
Destruction of the endometrium
59
While the previous Cycle's endometrium degenerates, the next Cycle's folecels are being produced, what does that tell us about the estrogen levels?
it is usually low, (when the endometrium develops, the estrogen level rises)
60
"HYPOTHALAMUS RELEASES GONADOTROPIN-RELEASING HORMONE (GnRH). Pay attention to the pulse rate. This stimulates the anterior pituitary to release FSH and LH." Hormones are not released at a \_\_\_\_\_\_\_\_\_\_\_\_\_\_. at the this starting point, our GnRH pulse frequency is usually \_\_\_\_\_\_\_\_\_\_\_\_. and FSH is released at \_\_\_\_\_\_\_\_\_\_\_\_\_
1) steady rate 2) medium 3) higher levels
61
FSH STIMULATES MATURATION OF \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_.
PRIMARY FOLLICLE
62
Developing follicles secrete slowly increasing amounts of \_\_\_\_\_\_\_\_\_\_\_\_\_. Eventually, ___________ will affect FSH levels.
1) estrogen & inhibin 2) inhibin
63
MATURING FOLLICLE SECRETES ESTROGEN. Estrogen: (A) at low levels, inhibits secretion of \_\_\_\_; (B) as it increases, builds the uterine wall (\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_).
1) LH ( low levels means that oocyte is not mature ) 2) endometrium (prepares it for the possibility that implantations can occur)
64
RISING LEVELS OF INHIBIN DECREASE FSH LEVELS. This dip in FSH levels, separates the _____________ from the rest.
dominant follicle
65
HIGH CONCENTRATION OF ESTROGEN LEADS TO __________ SECRETION. There is a change in GnRH pulse rate and the effect on LH is reversed. THE GnRH pulse freaquence is \_\_\_\_\_\_\_\_\_\_\_
1) INCREASE IN LH ( estrogent has to stay high for 3 days then LH will be secreted ) 2) high
66
HIGH LEVELS OF ESTROGEN STIMULATE SECRETION OF LH BY ANTERIOR PITUITARY. Spike in LH causes _____________ of primary oocyte & ______________ of the secondary oocyte – leaving follicle without egg which is called (\_\_\_\_\_\_\_\_\_\_\_\_\_\_). (Approximately day 15.) LH weakens the Outer wall of folicle
1) maturation 2) ovulation 3) the corpus luteum
67
Estrogen leads to the initial Development of _______________ and will handover those responsibilites to \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_, which will increase the vasculation and development of it (first blank), and also turn on the Secretion of \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
1) endometrium 2) progestrone 3) Uterine Glands
68
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ SECRETES ESTROGEN ANDPROGESTERONE. This maintains the endometrium for 15-16 days and inhibits \_\_\_\_\_\_\_\_\_\_\_. Hight progestrone results with ______________ GnRH pulse frequency.
1) CORPUS LUTEUM 2) FSH & LH. 3) Very LOW NOTE THAT **FSH** IS EVEN LOWER THAN **LH**.
69
HIGH PROGESTERONE LEVELS ____________ GnRH PULSE RATE. This change in pulse rate, coupled with inhibin secretion, keeps _____________ levels low.
1) DECREASE 2) Gonadotropin
70
(If oocyte is not \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_in the uterine wall) CORPUS DEGENERATES (TO \_\_\_\_\_\_\_\_\_\_\_\_\_) AND STOPS PRODUCING ESTROGEN AND PROGESTERONE.
1) fertilized and implanted 2) CORPUS ALBICANS
71
DECREASE IN PROGESTERONE AND ESTROGEN. Low Progesterone & Estrogen levels allow GnRH pulse rate to \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_. This allows an ______________ secretion by pituitary again. **The cycle is ready to repeat**.
1) slightly increase. 2) increase in FSH
72
WITHOUT ESTROGEN AND PROGESTERONE, ENDOMETRIUM BREAKS DOWN – ______________ OCCURS. which is the sloughing off of the enlarged endometrial wall along with \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_. This physical event marks \_\_\_\_\_\_\_\_\_\_ \_\_\_\_\_\_\_.
1) MENSTRUATION 2) blood and mucous 3) the beginning of the cycle.
73
IF – SOMEWHERE BETWEEN: HIGH LEVELS OF ESTROGEN STIMULATE SECRETION OF LH BY ANTERIOR PITUITARY. Spike in LH causes maturation of primary oocyte & ovulation of the secondary oocyte – leaving follicle without egg (the corpus luteum). (Approximately day 15.) And (If oocyte is not fertilized and implanted in the uterine wall) CORPUS DEGENERATES (TO CORPUS ALBICANS) AND STOPS PRODUCING ESTROGEN AND PROGESTERONE. SPERM GETS TO EGG. **THEN**
1) FERTILIZATION CAN TAKE PLACE, AND ULTIMATELY, EMBRYO CAN BECOME IMPLANTED IN UTERINE WALL.
74
Females can store sperm for about \_\_\_\_\_\_\_\_\_\_\_. (Also, it turns out that unused oocytes are actively scavenged.) With sex before ovulation, sperm can be stored for use. So, even though __________ hasn’t occurred, pregnancy can occur because the female is holding on to the sperm. From point of ovulation (about day 15) to the point where the corpus luteum begins to degenerate (about day 25), fertilization can take place. The potential for fertilization is highest during the \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
1) four days 2) ovulation 3) first three days of this 10-day period.
75
HORMONAL REGULATION IN PREGNANT FEMALES Developing embryo has _________________ membranes: chorion, amnion, yolk sac, and allantois. Chorion is the embryonic contribution to placenta. Chorionic portion secretes ______________________ (hCG). hCG prevents _______________ from degenerating – thus it continues to secrete PROGESTERONE AND ESTROGEN. This maintains integrity of uterine wall and inhibits subsequent _______________ (due to lack of FSH or LH). Hormonal birth-control mimics these high estrogen & progesterone levels to trick the body into thinking it is pregnant and thus inhibiting ovulation.
1) extra-embryonic 2) HUMAN CHORIONIC GONADOTROPIN 3) corpus luteum 4) ovulation