Humeral immunity Flashcards
(15 cards)
What type of immunity deals with antigen that are made of carbohydrate and lipids. A: Humeral B. Cytotoxic C: innate D: A and C E: B and C
D: Humeral immunity
- part of innate immunity:
Mediated by antibodies ▪ Produced by B lymphocytes
Where does affinity maturation and class switching occur:
a. Thymus
b. Germinal centers
c. bone marrow
B: This is Thymus dependent B cell activation, resulting in Antibody class switching and affinity maturation. T cell mediated response to only protein antigen.
What type of B cells interact with T helper cells, when a protein antigen is presented.
A. Marginal zone B cells in the spleen,
B. B1 cells found in muscosal and peritoneum areas.
C. Follicular B2 cells in the germinal centers.
C. follicular B2 cells
Of note Marginal Zone B cell and B1 cells are invloved in Thymus independent antibody formation reaction.
What Chemokine receptor guides B cell and T cells for the place where they are needed.
a. IFN gamma
b. IL 4
c. CCR7
d. CCR2
C: CCR7
What is the function of Tnf Beta
a. Somatic Hypermutation
b. Affinity maturation
c. Class switching
d. Promote class expression of AID
e. Downregulate Blimp 1: : repressor of genes associated with B cell proliferation
f. None of the above
g. All of the above.
G. All of the above.
TNF beta is produced by TfH cells and follicular dentritic cells.
What receptors guide T helper cell toward germinal cell to produce T follicular Helper cell (THf). A. CCR5. B. CCR7 C. CD22 D. IFN gamma
A. CCR5
Note TfH need ICOS co stimulator for proliferation. Tfh helps with antibody class switching and somatic hypermutation.
A six month child is brought to a PCP clinic for recurrent strep infections and fungal infections. Mother informs that his brother also has the same problem. Electrophoresis studies shows lack CD 40 L on T cells. What is the most likely diagnosis.
- DE George syndrome.
- Hyper IgM syndrome
- Marfan syndrome
- PKU
2.
TH cells don’t express CD40L, patients only produce IgM ✓No memory cell populations, no germinal centers
What is Fc gamma R3 (FcgammaRIII)
Involved in antibody dependent cellular toxicity. NK cell had CD 16 receptor that recognized the Fc gamma RIII on the antibody (with ag) and kills the antigen. It is part of the humeral immunity.
What is Fc gamma R one: Fc gamma RI
Part of the antibody Fc receptor that is involved in opsonization (Fab/Fc recognition). Ig G is the best Opsonizer
who is the best Complement activator a. IGg b. IGA C. IGE d. IGM
D: igM.
Ab that can cross mucosa via Poly IG receptors. a. IGg b. IGA C. IGE d. IGM
B. IGA
Mucosal: IGA; Has a longer half life. Has FcRn receptor in the neonate and creates an endosome around it. Only released if needed.
What antibody is present in Mother's milk a. IGg b. IGA C. IGE d. IGM
b. IGA
IgE Ab present receptors present in which of the following granulocytes.
a. Mast cell
b. basophils
c. Eosinophil
d. Eosinophil and mast cells
e. Eosinophils, mast cells, and basophils.
E. all of them
What receptor APCs have to bind to Antibody -C3b complex for phagocytosis.
a. CR1
b. CR2
3. C3a
4. CR3
A. CRI is a receptor for complement/ab recognition for phagocytosis.
Is it true to never give a live vaccine to a child less than 12 yrs old
Yes
No
Yes: Live vaccines will make abs that will compete and are inactivated by mother’s residual abs and also
we will be exhausting mother’s ab supply.
note: babies only have IgM for being positive for any pathogenic infx.
