Humoral Control Flashcards
1
Q
what are some circulating (humoral) factors that regulate circulatory function?
A
- arginine vasopressin (AVP, ADH)
- endothelium derived factors
- aldosterone
- adrenal catecholamines
- renin angiotensin system (RAS)
- kallikrein-kinin system
2
Q
what are the main substances (we talk about) that modulate blood pressure?
A
- catecholamines (NE and E)
- RAS (Ang II)
- Kallikrein-kinin system (bradykinin)
- endothelium derived factors (EDRF = NO)
3
Q
what happens in the Renin-Angiotensin system when there is a decrease in BP?
- part 1
A
4
Q
what happens in the Renin-Angiotensin system when there is a decrease in BP?
- part 2
A
5
Q
what is critical in the compensatory response to hemorrhage? why?
A
RAS
- because it helps maintain the blood pressure
6
Q
how does the kallikrein-kinin system play a role in BP regulation?
A
7
Q
how is the kallikrein-kinin and RAS system coupled?
A
8
Q
what kind of medications help control blood pressure? how do they do so? what are some examples?
A
- beta blockers
- propanolol
- atenolol
- metoprolol
9
Q
how is vascular tone regulated by endothelial cells?
A
- increase stretch, ACh, Histamine, ATP, bradykinin to endothelial cell
- endothelial cell produces NO
- NO leaves endothelial cell
- NO enters smooth muscle (or PGI2/PGE2 leave end. cell and enter smooth muscle)
- increase vasodilation
OR - endothelial cell produces endothelin
- endothelin enters smooth muscle
- increase vasoconstriction
- know the picture too
