Hypercoagulability

Question 1

Antithrombin Deficiency

Answer 1

Inherited deficiency of antithrombin, no direct effect on PT, PTT, or thrombin time but diminishes the increase of PTT following heparin administration because heparin usually activates antithrombin

Question 2

Factor V Leiden (what it is, demographic)

Answer 2

Production of mutant factor V resistant to degradation by activated Protein C
Most common inherited hypercoagulability, especially in whites

Question 3

Protein C or S Deficiency

Answer 3

Normally inactivate factors V and VIII (accelerating factors) but can’t now. Increases risk for thrombotic skin necrosis with hemorrhage following administration of warfarin (because eliminates what little C and S you have)

Question 4

Prothromin gene mutation

Answer 4

Point mutation causes increased production leading to more thrombin/clots