Hyperestrinism in Dog Flashcards Preview

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Flashcards in Hyperestrinism in Dog Deck (25):
1

Common causes hyperestrinism in Dogs

  1. Cystic ovaries
    • dog goes into heat and doesn't come out
  2. Granulosa cell tumores
  3. Sertoli Cell tumors
    • all kinds can feminize male dogs
  4. Estrogen drugs
    • menopause creams

2

Clinical Signs hyerestrinism

  • Vulvar edema +/- d/c
  • Alopecia caudal trunk and perineum
  • Epidermal hyperpigmentation
  • Nipple enlargement
  • Attractive to other dogs

3

Hyperestrinism can cause _____

  • Myelotoxicity
    • anemia
    • leukopenia
    • thrombocytopenia

*get a CBC on these dogs

4

Hyperestrinism TX

  • Spay
  • remove drugs

5

Consequences of myelotoxicity

  • No white cells => infection
  • No platelets => bleed
  • No RBCs => tissue oxygen deprivation

6

Pale patechia

  • could be an anemic TCP

7

Prognosis and TX pancytopenia

  • Bone marrow bx to prognose
    • no precursor cells (aplastic) => grave sign
      • give blood products, Neupogen, Epogen
      • remove source of estrogen

8

Take home message

Hyperestrinism in female

  • Often due to cystic ovaries
  • Alopecia posterior and ventral
  • vulvar enlargement and serosanguineous discharch
  • OHE
  • Neupogen and Epogen for myelotoxicosis

9

3 cell types of testicular tumors

  1. Sertoli
    • can metastasize and feminize
  2. Seminoma
    • can metastasize and feminize
  3. Interstitial (Leydig)
    • mets rare, feminization rare

10

Incidence of sertoli cell neoplasia

  • 3-20 yrs old (ave 8-9)
  • Dogs with extrascrotal involvement with feminization may present at a younger age than dogs with scrotal involvement
    • intraabdominal have higher rate of feminization

11

Site of involvement

  • Usually unilateral
  • Right cryptorchid teste common
  • 30-40% are extrascrotal
    • inguinal
    • abodminal

12

Clinical signs of Feminization

  • Prostatic changes: metaplasia, infection => obstruction, cysts
  • Atrophy of contralateral testicle => one in scrotum usually small
  • Symmetrical alopecia
  • Gynecomastia => breat development
  • Pendulous prepuce
  • Tendency to attract other male dogs
  • depressed libido
  • lethargy

13

Prostatic carcinomas like to met to ____

Ventral vertebral bodies

14

Sertoli cell tumors act like _____

Carcinomas

15

Take home message

Sertoli Cell:

  • Feminization is a sentinel
  • All 3 tumor types in all 3 locations can cause feminization
  • Assess for myelosuppression
  • Asses for prostatic infection

16

Pyometra has a(n) _____ effect on the body

Endotoxemic

-usually due to E. Coli

17

Uteromegaly causes

  • Pregnancy
  • Cystic endometrial hyperplasia
  • Pyo, Muco, Hydro
  • Tumors
  • Torsion

18

Endometrial hyperplasia and secretion of glands mediated by

TEST QUESTION

progesterone

19

Pyometra predisoposing drugs

  • Megestrol Acetate
  • Progesterone

20

Clinical signs of Pyometra

  • Onset symptoms 4-12 weeks after estrus
  • PU/PD
  • vaginal d/c in 50-60% cases
  • Anorexia, dec apetite
  • depression
  • abdominal distention
  • Temp (depends)
    • often not febrile
  • Can also be VERY SICK
  • diabetes....?
  • Kidney failure....?

21

Systemic Effects of pyo

  • Anemia
  • Cardiac arrhythmias
  • Impaired renal function
  • Sepsis - E. Coli
  • Toxemia

22

E. Coli blocks

  • ADH at receptor site of collecting duct and distal renal segment
    • prevents ADH from making aquaporin

23

DX of pyo

  • HX and PE
  • Hematology can be weird
    • leukocytosis from 15,000-100,000
  • Abdominal rads
  • Abdominal ultrasound

24

Pyo TX

  • IV crystalloids (fluids)
    • volume replete, verify Urine output the SX, check Blood glucose too
  • Antibiotics: Gram (-)
  • OHE
  • Prostaglandin F2alpha
    • breeders that want animals intact
    • stimulates uterine contraction
      • must be an open pyo
      • animal will be sick for a few days
      • these animal predisposed for relapse

25

Never forget! => Any sick intact dog/cat

  • always consider and rule out pyometra
  • be careful of histories that claim animal is spayed
  • never let the sun set on a sick pyo