Hyperlipidemia Types

Question 1

Type I, Familial Hyperchylomicronemia

Answer 1

Increased Chylomicrons + TAGs
Abnormal ApoCII + LPL
Risk for Hepatospenomegaly, Pancreatitis, Eruptive Xanthomas

Question 2

Type IIA, Familial Hypercholesterolemia

Answer 2

Increased LDL + Cholesterol
Deficient LDL receptor
Increased staining of Beta protein
Risk for Atherosclerosis, Coronary Artery Disease, Tendon Xanthomas & Xanthelasma

Question 3

Type IIB, Familial Combined Hyperlipidema

Answer 3

High LDL+VLDL+Cholesterol+TAGs & Low HDL
Deficient ApoB100 + LDL receptor & overproduction of VLDL
Spikes in Beta & Pre-Beta bands
No Xanthomas

Question 4

Type III, Dysbetalipoproteinemia

Answer 4

Increase IDL + VLDL (Chylomicron Remnants)
Smeared/Increased staining between Beta & Prebeta
Deficient ApoE
Risk for xanthomas: palmar + elbows + knees

Question 5

Type IV, Hyperprebetalipoproteinemia

Answer 5

Increased VLDL + TAGs, Decreased HDL
Abnormal PDP & overproduction of VLDL (prebeta)
Risk for Pancreatitis

Question 6

Type V, Familial Mixed Hypertriacylglycerolemia

Answer 6

Increased Chylomicrons + VLDL

Deficient LPL + ApoCII & overproduction of VLDL