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Immunology > Hypersensitivity > Flashcards

Hypersensitivity Flashcards

1
Q

Type I hypersensitivity immune mediator

A

IgE

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2
Q

Type II hypersensitivity immune mediator

A

IgG

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3
Q

Type III hypersensitivity immune mediator

A

IgG

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4
Q

Type IV hypersensitivity immune mediator

A

T cells

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5
Q

Type I hypersensitivity antigen type

A

Soluble

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6
Q

Type II hypersensitivity antigen type

A

Cell-associated or cell-surface

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7
Q

Type III antigen type

A

soluble

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8
Q

Type IV antigen type

A

Soluble or cell-associated

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9
Q

Mast cells play a major role in this type of reaction

A

Type I

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10
Q

Type I reactions are also known as

A

Immediate-type

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11
Q

Type II reactions are also known as

A

modified self

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12
Q

Type III reactions are also known as

A

immune complex

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13
Q

Type IV reactions are also known as

A

delayed-type

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14
Q

Which T cell type helps in production of IgE?

A

Th2 (not Th1!)

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15
Q

Only one hypersensitivity reaction starts within minutes of exposure to the antigen

A

Type I

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16
Q

Type I hypersensitivity reactions only develop against this type of antigen

A

Proteins (only kind T cell can recognize)

17
Q

Allergens are usually this kind of enzyme

A

protease

18
Q

Features of typical allergen

A

Low MW; protease; low concentrations; soluble

19
Q

Array of effector molecules released by mast cells

A

Histamine; heparin, TNF-alpha, tryptase

20
Q

Penicillin-induced hypersensitivity is which type

A

II

21
Q

Penicillin-induced hypersensitivity can cause RBC destruction through these 2 ways

A

MAC and antibody opsonization/Fc receptor of phagocytes

22
Q

Type II involves which complement receptors and Fc receptors

A

C5a, C5a receptor, Fc-gamma-3

23
Q

Farmer’s lung type of reaction

A

III

24
Q

Bird-Fancier diseases type of reaction

A

III

25
Q

Poison ivy type of reaction

A

IV

26
Q

Type IV reactions are characterized by this onset timeframe

A

24-72 hours

27
Q

The tuberculin reaction is this type

A

IV

Immunology (3 decks)

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