hypersensitivity autoimmunity

Question 1

what is the antibody in type 1 hypersensitivity

Answer 1

IgE

Question 2

what is the action of type 1 hypersensitivity

Answer 2

Immediate hypersensitivity diseases are initiated by the introduction of an allergen, which stimulates TH2 reactions and IgE production. IgE sensitizes mast cells by binding to FcεRI , and subsequent exposure to the allergen activates the mast cells to secrete the mediators that are responsible for the pathologic reactions of immediate hypersensitivity.

Question 3

type 1 “immediate” recation

Answer 3

mast cell activation

igE mediated effects and vasodialtion

Question 4

type 1 “late” reaction

Answer 4

Eosinophil, neutrophil and T cell infiltrates

Question 5

what are the examples of autoimmune disease

Answer 5

systemic and organ specific

Question 6

systeic autoimmune disease

Answer 6

Autoimmune process is diffuse is spread throughout the body

Affects more than one organ - not necessarily the same ones in different individuals

Question 7

organ specific autoimmne disease

Answer 7

Autoimmune process directed against one organ
Type 1 Diabetes - pancreas
Autoimmune Thyroiditis

Question 8

Systemic lupus erythematosus

Answer 8

Relapsing and remitting chronic
systemic disease

Primarily affects women in
20’s - 60’s

Question 9

define Hypersensitivity responses

Answer 9

damaging responses produced during normal immune responses

Question 10

describe autoimmune disease

Answer 10

• a failure or breakdown of immune system that maintains tolerance to self tissues

Question 11

Loss of tolerance is probably due to abnormal selection or lack of control of

Answer 11

self-reactive lymphocytes (B and T-cells)

Question 12

what is an autoimmune disease

Answer 12

a failure or breakdown of immune system that maintains tolerance to self tissues

Question 13

what are the 4 catogories of hypersensitivity responses

Answer 13

1, 2, 3 and 4

Question 14

which hypsensistivity are antibody mediated?

Answer 14

1, 2 and 3

Question 15

which hypersensitivity is T cell mediated

Answer 15

4

Question 16

what would cuase a hypersensitive response catorgory 1? abd what is the antibody and what does it connect to?

Answer 16

allergy

IgE solubl antigen (water soluble)

Question 17

what antibody is type 2? and what does it connect 2?

and what is it used for?

Answer 17

IgG

cell or matrix antigen

`atp
rheumatic
fever

Question 18

what are antibodies for type 4

and what are they used for?

Answer 18

Th1 and th2 and cytotoxic (CTL)

diabetes, MS

Question 19

when do you get immediate release?

Answer 19

when the antibody cross liked with the antigen

Question 20

what are the type of effects of the immediate reactions?

Answer 20

vasodialtion, vascular leak, broncho- constriction, intestinal hypermotility, inflammation, tissue damage

Question 21

what is atopy

Answer 21

predisposition to developing allergies