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MOD 2 > Hypersensitivity Diseases > Flashcards

Hypersensitivity Diseases Flashcards

(47 cards)

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1
Q

Sjogren syndrome auto-ab

A

anti Ro/SS-A

anti La/SS-B

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2
Q

CREST auto-ab

A

anticentromeric antibody

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3
Q

Pernicious anemia = what hypersensitivity

A

Type 2

Neutralization

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4
Q

SLE auto-ab

A

anti-ds DNA

anti-Sm

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5
Q

Discoid lupus auto-ab

A

(-) Anti-DS DNA

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6
Q

Goodpasture syndrome Auto-Ab

A

anti-basement membrane, anti-tupe 4 collagen

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7
Q

NOD2

A

Chron’s

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8
Q

Autoimmune hemolytic anemia

Autoimmune thrombocytopenic purpura

A

Type 2

Opsonization + Phagocytosis

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9
Q

Ankylosing spondylitis (HLA alleles B 2705 + B 2702) hugely predisposes you to?

A

Autoimmune disease

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10
Q

PTPN22

A

Rheumatoid arthritis, type 1 diabetes

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11
Q

Autoimmune diseases on the rise because?

A

Less IL-2 –> need to maintain T regs

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12
Q

What are the 4 diseases of type 2 hypersensitivity from antibody-mediated cellular dysfunction?

A

Myasthemia gravis

Graves

Insulin-resistant diabetes

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13
Q

What are the 3 types of type 2 hypersensitivity reactions?

A
  1. Opsonization + phagocytosis
  2. Inflammation (from complement)
  3. Antibody-mediated cellular dysfunction
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14
Q

Reactions where antibodies directly react w/ antigens present on the cell surface = what hypersensitivity

A

Type 2

smooth, linear

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15
Q

Hypersensitivity reaction mediated by T cells:

A

Type 4

Granuloma

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16
Q

Tuberculosis

A

Type 4

Delayed Type Hypersensitivity

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17
Q

Eosinophilic esophagitis

A

Type 1

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18
Q

“Antigen-antibody complexes form and deposit, causing damage”

how doe sit look?

A

Type 3

Grainy, granular

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19
Q

Systemic sclerosis (scleraderma) auto-ab

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A

anti-DNA topoisomerase

20
Q

Poststreptococcal glomerulonephritis =

21
Q

What are Type 1 Hypersensitivity Reactions?

Study These Flashcards
A

Seasonal Allergies

Food allergies

Asthma

Severe Allergic Reactions (hives, angioedema, anaphylaxis)

22
Q

Mixed connective tissue disease auto-ab

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A

anti-U1-ribonucleoprotein

23
Q

Serum sickness + Arthus reaction =

24
Q

Opsonization + phagocytosis lead to –> which Sx?

Study These Flashcards
A

Anemia

Thrombocytopenia

25
IgG4 =
Mickulicz Autoimmune pancreatitis
26
What are the 6 types of type 4 hypersensitivity reactions?
**I**n **R**ural **M**ontana **P**eople **T**ip **C**ows Inflammatory Bowel Disease Rheumatoid Arthritis Mltiple Sclerosis Psoriasis Type 1 Diabetes Contact Sensitivity (from posion ivy/nickel)
27
What is eosinophilic esophagitis?
Can't swallow effectivitly/hurts to swallow --\> weight loss
28
Lupus Erythematosus: associated w/ persistent antibody resposnses to autoantigens
Type 3
29
Inflammation + damaged tissue lead to which hypersensitivity reactions?
Type 2 - Vasculitis by ANCA, Goodpasture syndrome, Acute rheumatic fever
30
drug-induced SLE auto-ab
anti-histone Ab
31
X-linked agammglobunemia
BTK (bruton tyrosine kinase) Inability of pre-B cells to mature
32
Hyper - IgM
CD40L mutation on T cells Interfere w/ T cells helping B cells to class-switch --\> result is high levels of default IgM
33
**X-linked SCID** (more common) AR SCID
cytokine y chain adenosine deaminase
34
CVID
Multiple disoders resulting in hypogammaglobulinemia Diagnosis of exclusion Chronic diarrhea, anemia, thrombocytopenia, recurrent sinus + pulmonary infections (lack of IgA)
35
IgA deficiency
IgA deficiency can cause **recurrent sinus infections / UTIs.** The main presentation however is an **anaphylactic reaction to blood transfusion**. In response, we can either wash out the IgA, or give a transfusion from IgA deficient donors.
36
Wiskcott-Aldrich 3 things:
Eczema Thrombocytopenia Recurrent infections
37
Ataxia Telegiectasia
Ataxia telangiectasia is a rare genetic disease that presents first with neurodegenerative sx, but then progresses to vascular malformation (telangiectasias towards the iris), and sx of IgA and IgG deficiency. These include respiratory infections, and a dramatically increased risk of lymphoma. AR - ATM mutation
38
Skin MCC
Basal cell carcinoma #1 squamous cell carcinoma malignant melanoma
39
brain MCC
glial neoplasm
40
What most common cancers are squamous cell carcinoma?
oral cavity, head, neck lung (4th) cervix esophagus skin (2nd)
41
Adenocarcinoma
lung pancreas large bowel (colon) kidney prostate Endometrium
42
breast MCC
invasixe ductal carcinoma
43
bladder MCC + pelvis of kidney
transitional epithelium
44
Liver MCC
hepatocellular carcinoma
45
Testes
germ cell origin
46
Most common cancers of adults in western society
Skin Oral cavity, head, neck Lung Large bowel (colon) Prostate Breast Cervix
47
Lung MCC
adenocarcinoma #1 small/large cell undifferentiated carcinoma squamous cell carcinoma

MOD 2 (9 decks)

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