Hypersensitivity Disorders - Autoantibodies Flashcards Preview

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Flashcards in Hypersensitivity Disorders - Autoantibodies Deck (25)
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1

What autoantibody is associated with ... Antiphospholipid Syndrome (Hugh's syndrome) ?

IgG Antibodies against cardiolipin and beta2 glycoprotein, lupus anticoagulant

2

What autoantibody is associated with ...Autoimmune Hepatitis?

IgG - Anti-smooth muscle antibody, anti-liver kidney microsomal-1 (anti-LKM-1). Anti Soluble Liver antigen (anti-SLA)

3

What autoantibody is associated with ...Autoimmune haemolytic anaemia?

IgG- Anti-Rh blood group antigen

4

What autoantibody is associated with ... Autoimmune Thrombocytopenic Purpura?

IgG - Anti-Glycoprotein IIb-IIIa or Ib-IX antibody

5

What autoantibody is associated with ... Churg-Strauss Syndrome (eGPA)?

Perinuclear/protoplasmic-stainng antineutrophil cytoplasmic antibodies (p-ANCA)

6

What autoantibody is associated with ... Coeliac disease?

IgA - Anti-tissue transglutaminase antibody, Anti-endomysial antibody

7

What autoantibody is associated with ... Congenital heart block in infants of mothers with SLE?

IgG - Anti-Ro antibody

8

What autoantibody is associated with ... Dermatitis hepetiformis?

IgA - anti-endomysial antibody

9

What autoantibody is associated with ...Dermatomyositis?

IgG - Anti-Jo-1 (t-RNA Synthetase)

10

What autoantibody is associated with ... Diffuse Cutaneous Scleroderma?

IgG - Antibodies to Topoisomerase/Scl70, RNA Pol I, II, III, Fibrillarin (nucleolar pattern)

11

What autoantibody is associated with ... Goodpasture's Syndrome?

IgG - Anti-GBM antibody

12

What autoantibody is associated with ...Graves Disease?

IgG - Anti-TSH Receptor antibody (stimuatory antibody)

13

What autoantibody is associated with ... Hashimoto's Thyroiditis?

IgG - Antibodies to Thyroiglobulin and thyroperoxidase

14

What autoantibody is associated with ... Limited Cutaneous scleroderma (CREST)

IgG - Anti-centromere antibody

15

What autoantibody is associated with ... Microscopic Polyangitis (MPA)?

IgG- Perinuclear.protoplasmic-staining antineutrophil cytoplasmic antibodies (p-ANCA)

16

What autoantibody is associated with ... Mixed connective tissue disease?

IgG- Anti-U1RNP antibody (speckled pattern)

17

What autoantibody is associated with ... Myasthenia Gravis?

IgG- Anti-ACh Receptor Antibody

18

What autoantibody is associated with ... Pernicious anaemia?

IgG - Antibodies to gastric parietal cells (90%) and intrinsic factor (50%)

19

What autoantibody is associated with ... Polymyositis?

IgG - Anti-Jo-1 (t-RNA Synthetase)

20

What autoantibody is associated with ... Primary Biliary Cirrhosis?

IgG- Anti-mitochondrial antibody

21

What autoantibody is associated with ... Rheumatoid Arthritis?

IgG- Anti-CCP antibodies, Rheumatoid factor

22

What autoantibody is associated with ... Sjogren's Sundrome?

IgG - Anti-Ro, Anti-La antibody (speckled pattern), 60-70% have positive RF

23

What autoantibody is associated with ... Systemic Lupus Erthematosis?

IgG - Antibodies to dsDNA+ histones (Homogenous) and Ro LA, Sm, U1RNP (speckled)

24

What autoantibody is associated with ... Type 1 Diabetes Mellitus?

IgG - Antibodies to Glutamate Decarboxylase and pancreatic beta cells

25

What autoantibody is associated with ... Wegener's Granulomatosis (GPA)?

IgG - Cytoplasmic antinutrophil cytoplasmic antibodies (c-ANCA)