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Flashcards in Immune Therapies Deck (65)
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1

What are the 7 classes of Immune therapies?

Anti- T cell monoclonal antibodies
Anti Proliferative Agents
Inhibitors of cell Signalling
Corticosteroids
Plasmapharesis
Anti TNFalpha Monoclonal Antibodies
Anti IL-12/23 Monoclonal Antibody

2

4 Examples of Anti T cell Monoclonal Antibodies

1) Muromonab-CD3
2)Basiliximab
3)Tocilizumab
4) Abatacept

3

What is the Method of action of Muromonab-CD3?

Blocks CD3 on T cells

4

What is Muromonab-CD3 used for?

For active rejection

5

What are the side effects of Muromonab-CD3?

Fever
Leucopenia

6

What is the method of action of Basiliximab?

Blocks CD25 (alpha chain of IL-2 Receptor)

7

What is Basiliximab used for?

Prevents rejection in Transplantation

8

What are the side effects of Basiliximab?

GI disturbances

9

What is the method of action of Tocilizumab?

Blocks IL-6 receptor

10

What is Tocilizumab used for?

Rheumatoid arthritis if Anti-TNF drugs have failed

11

What are the side effects of Tocilizumab?

Infections

12

What is the method of action of Abatacept?

Anti C TLA-4 Ig, Blocks Co stimulation of T cells

13

What is Abatacept used for?

Rheumatoid arthritis if Anti-TNF drugs have failed

14

What are the side effects of Abatacept?

Inections and cough

15

3 examples of Anti proliferative Agents?

1) Cyclophosphamide
2) Mycophenolate
3) Azathioprine

16

What is the method of action of Cyclophosphamide?

Alkylates guanine base of DNA. Affects B>T cells

17

What is Cyclophosphamide used for?

Muti-system connective tissue diseases (e.g. SLE) and Cancer

18

What are the side effects of Cyclophosphamide?

Hair Loss, Bone marrow suppression, Sterility, Haemorrhagic cystitis

19

What is the method of action of Mycophenolate?

Blocks de novo nucleotide synthesis. Affects T>B cells

20

What is Mycophenolate used for?

Autoimmune Disease, Vasculitis, Transplantation

21

What are the side effects of Mycophenolate?

Bone Marrow Suppression, Herpes

22

What is the method of action of Azathioprine?

Metabolised to 6-Mercaptopurine in the liver. Blocks de novo purine synthesis

23

What is Azathioprine used for?

Inflammatory and Autoimmune disease, Transplantation

24

What are the side effects of Azathioprine?

Bone Marrow Suppression (measure TPMT), Hepatotoxicity

25

Give 3 examples of immune Therapies that are 'inhibitors of cell signalling'

1) Tacrolimus
2) Ciclosporin
3) Sirolimus

26

What is the method of action of Tacrolimus?

Inhibits Calcineurin which normally activated the transcription of IL-2 therefore decreased IL-2

27

What is Tacrolimus used for?

Mainly rejection prophylaxis in transplantation

28

What are the side effects of Tacrolimus?

Diabetes

29

What is the method of action of Ciclosporin?

Inhibits Calcineurin which normally activated the transcription of IL-2 therefore decreased IL-2

30

What is Ciclosporin used for?

Mainly rejection prophylaxis in transplantation