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Flashcards in Hypersensitivity reaction Deck (101):
1

anaphylactic and atopic (type I) hypersensitivity reaction - delayed respond - cells ?

neutrophils and eosinophils

2

Pernicious anemia antibodies

antiparietal antibodies

3

Lupus antibodies

1. Anticardiolipine (SLE, antiphospholipid syndrome)
2. lupus anticoagulant (SLE, antiphospholipid syndrome)
3. Anti-dsDNA (SLE, specific, poor prognosis - renal)
4. Anti-Smith (SLE, specific, no prognostic)
5. anti-histone (drug induced lupus)
6. anti-β2 glycoprotein antibodies (antiphospholipid syndrome)
7. ANA (SLE, sensitive, nonspecific)

4

eosinophil produce

1. histaminase
2. Major basic protein (a helminthotoxic)

5

Blood transfusion reaction - Febrile nonhemolytic transfusion reaction - treatment

acetaminophen

6

Anti-hemidesmosome - disease

bullous pemphigoid

7

IgA-deficiency and blood transfusion

IgA-deficient patients with anti-IgA IgEs are at risk for anaphylaxis if they receive blood or intravenous immunoglobulin (rare)

8

Anti-basement membrane - disease

Goodpasture

9

Blood transfusion reaction - anaphylactic reaction mechanism

severe allergic reaction.

10

DM1 -anybodies

anti-glutamic acid decarboxylase (GAD-65) -

11

anti-Mi-2 - disease

1. polymyositis
2. dermatomyositi

12

direct Coomb's test - definition and example

detects antibodies that have adhered to patient's RBCs
eg. test an Rh infant of an Rh mother

13

Basophil contains

1. heparin (densly basophilic granules)
2. histamine (densly basophilic granules)
3. synthesie and release leukotrienes

14

anti-Smith - disease

SLE

15

IgA anti-endomysial

Celiac disease

16

anticardiolipine - disease

SLE
antiphospolypid syndrome

17

Mast cells releases

1. histamine
2. tryptase
3. eosinophil chemotactic factor
4. heparin

18

Blood transfusion reaction - Febrile nonhemolytic transfusion reaction - mechanism

type II hypersensitivity reaction --> host antibodies against donor HLA antignes and WBCs
NO HEMOLYSIS

19

voltage-gated calcium channel antibodies - disease

Lambert Eaton

20

Anti-desmoglein (anti-desmosomes) - disease

Pemphigus vulgaris

21

anti-CCP - disease

RA (more specific)

22

anti-glutamic acid decarboxylase (GAD-65) - disease

DM1

23

anaphylactic and atopic (type I) hypersensitivity reaction - test

skin test for specific IgE

24

Serum sickness - symptoms

1. Fever
2. Urticaria
3. arthralgia
4. proteinuria
5. lymphadeonpathy
6. splenomegaly
7. eosinophilia
OCCURS 5-10 DAYS AFTER ANTIGEN EXPOSURE

25

Blood transfusion reaction - acute hemolytic transfusion reaction - intravascular or extravascular hemolysis?

both

26

Sjogren antibodies

1. Anti-SSA
2. Anti-SSB (anti-Ro, anti-La)

27

Delayed (cell mediated) Hypersensitivity reaction (IV) - mechanism

sensitized T cells encounter antigen and then release cytokine (leads to macrophages activation)
DOES NOT INVOLVE ANTIBODIES (vs I, II, III)

28

Anticentromere - disease

Limeted scleroderma (CREST syndrome)

29

Arthus reaction - diagnosis

immunofluorescent stating

30

dermatomyositis antibodies

1. Anti-jo
2. Anti-SRP
3. Anti-Mi-2

31

PR3-ANCA/c-ANCA - disease

granoulomatosis with polyangiitis (Wegener)

32

Blood transfusion reaction - allergic type - mechanism

type I hypersensitivity against plasma proteins in transfused blood

33

Anti-Jo-1 - disease

1. polymyositis
2. dermatomyositis

34

Polymyositis antibodies

1. Anti-jo
2. Anti-SRP
3. Anti-Mi-2

35

Hypersensitivity reaction - types

1. anaphylactic and atopic (type I)
2. Cytotoxic (antibody mediated, type II)
3. Immune complex (type III)
4. Delayed (cell mediated, type IV)

36

Blood transfusion reaction - anaphylactic reaction - treatment

epnephrine

37

anaphylactic and atopic (type I) hypersensitivity reaction - examples

1. allergic and atopic disorder (eg. rhinitis, hay fever, eczema, hives, asthma)
2. Anaphylaxis (eg. bee sting, some food/drug allergies

38

Cytotoxic (antibody mediated) Hypersensitivity reaction - types of antibodies

IgM
IgG

39

vasculitis - antibodies

1. Microscopic polyangitis --> MPO-ANCA/p-ANCA - disease
2. eosinophilic granulomatosis with polyangitis (Churg strauus) --> MPO-ANCA/p-ANCA - disease
3. granoulomatosis with polyangiitis (Wegener) --> PR3-ANCA/c-ANCA

40

Hypersensitivity reaction type IV - test

1. patch test
2. PPD

41

haptens are

small molecules that elicit an immune response only when attached to a large carrier (eg. protein) which may be one that also does not elicit an immune response by itself

42

Crest syndrome - antibodies

Anticentromere

43

bullous pemphigoid - antibodies

Anti-hemidesmosome

44

Arthus reaction vs serum sickness according to time and which is the MC

Arthus reaction --> 3-6h MC
serum sickness --> 5 days

45

antithyroglobulin - disease

Hashimoto

46

Anti-smooth muscle

Autoimmune hepatitis type 1

47

anti-dsDNA - disease

SLE

48

Celiac disease - antibodies

1. IgA anti-endomysial
2. IgA anti-tissue transglumatiminase

49

Arthus reaction - mechanism

local sabacute antibody-mediated hypersensitivity reaction --> intradermal (or subcutaneous) injection into a presensitized (has circulating IgG individual leads to immune complex formation in the skin --> activation of complement --> PMN infiltration and platelet clumbing

50

Hypersensitivity reaction type IV - example of diseases (3)

1. Contact dermatitis (poison IV, nickel allergy)
2. graft-vs-host disease
3. Multiple sclerosis

51

Arthus reaction - symptoms

edema and necrosis

52

antiparietal cell - disease

pernicious anemia

53

indirect Coomb's test - definition and example

detects serum antibodies that can adhere to other RBCs
eg. test in Rh- woman for Rh+ antibodies)

54

Cytotoxic (antibody mediated) Hypersensitivity reaction - example of a nervous system disease

Guiillain Barre syndrome

55

antiphospholipase A2 receptor - disease

primary membranous neuropathy

56

Immune complex Hypersensitivity reaction - examples of diseases

1. SLE
2. Polyarteritis nodosa
3. Poststreptococcal glomerulonephritis
4. Serum sickness
5. Arthus reaction

57

Blood transfusion reaction - acute hemolytic transfusion reaction - mechanism

Type II hypersensitivity reaction --> intravascular hemolysis (ABO incompatibility) or extravascular hemolysis (host antibody reaction against foreign antigen on donor RBCs)

58

mixed connective tissue disease - antibodies

anti-U1 RNP

59

primary membranous neuropahty antibodies

Antiphospholipase A2 receptor

60

Blood transfusion reaction - acute hemolytic transfusion reaction - clinical manifestations

1. fever
2. hypotension
3. tachypnea
4. tachycardia
5. flank pain
6. hemoglobinuria (intrav hemolysis)
7. jaundice (extravascular hemolysis)

61

Serum sickness - antibodies formation takes .... (time)

5 days

62

MPO-ANCA/p-ANCA - disease

Microscopic polyangitis
eosinophilic granulomatosis with polyangitis (Churg strauus)

63

MC serum sickness is caused by

drugs (not serum) acting as haptens

64

Serum sickness - mechanism

antibodies formation to foreign proteins (take 5 days) --> immune complexes formation and deposition in membranes --> the fix complement --> tissue damage

65

Arthus reaction - examples

tetanus immunization if they are gince at the same site with too short an interval interval between immunizations (min interval us usually 5 yrs)

66

Anti-ACh receptors - disease

Myasthenia gravis

67

antimicrosomal - disease

Hashimoto

68

anti-histone - disease

drug induced lupus

69

Blood transfusion reaction - anaphylactic reaction - clinical manifestation

1. Dyspnea
2. Bronchospasm
3. Hypotension
4. Respiratory arrest
5. shock

70

Rheumatoid arthritis - antibodies

1. Rhematoid factor
2. anti-CCP (more specific)

71

Blood transfusion reaction - types

1. allergic reaction
2. Anaphylactic reaction
3. Febrile nonhemolytic transfusion reaction
4. Acutehemolytic tranfusion reaction

72

primary biliary cirrhosis antibodies

Antimitochondrial

73

Blood transfusion reaction - allergic type - treatment

antihistamines

74

Immune complex Hypersensitivity reaction - mechanism

antigen-antibody (IgG) complexes --> activate complement --> attracts neutrophils which release lysosomal enzymes

75

Rhematoid factor?

IgM antibody that targets IgG Fc region

76

Pemphigus vulgaris - antibodies

Anti-desmoglein (anti-desmosomes)

77

anti-U1 RNP - disease

mixed connective tissue disease

78

Autoimmune hepatitis type 1 antibodies

Anti-smooth muscle

79

Lupus antigoagulant

SLE
antiphospolypid syndrome

80

Cytotoxic (antibody mediated) Hypersensitivity reaction - disease tends to be specific on

tissue or site where antigen is found

81

antinuclear (ANA) - disease

SLE (nonspecific)

82

Anti-SRP1 - disease

1. polymyositis
2. dermatomyositis

83

anti-TSH receptor

Graves disease

84

IgA anti-tissue transglumatiminase

Celiac disease

85

anti-β2 glycoprotein antibodies - disease

antiphospholipid syndrome

86

Anti-SCL-70 (anti-DNA topoisomerase I)

diffuse scleroderma

87

diffuse scleroderma antibodies

Anti-SCL-70 (anti-DNA topoisomerase I)

88

Anti-SSB (anti-Ro, anti-La) - disease

Sjogren syndrome

89

Cytotoxic (antibody mediated) Hypersensitivity reaction - mechanism

IgM, IgG bind to fixed antigen on "enemy" cell --> complement activation --> membrane attack complex (MAC) --> a. opsonizaiton and phagoyctosis b. complement and Fc-mediated inflammation c. antibody-mediated cellular dysfunction

90

anaphylactic and atopic (type I) hypersensitivity reaction - mechanism

Antigen induce the formation of IgE (through Th2 and Il-4) --> Reexposure -->
Free antigen cross-links IgE on presenting mast cells and basophils, triggering immediate release of vasoactive amines that act at postcapillary venules (eg. histamine). Rapidly reaction because of preforemed antibody --> Delayed response due to production of arachindoinc acid metabolites (eg. Leukotrienes) --> neutrophils and eosinophils

91

Blood transfusion reaction - allergic type - clinical presentation

1. urticaria
2. pruritus
3. wheezing
4. fever

92

Anti-SSA - disease

Sjogren syndrome

93

Blood transfusion reaction - acute hemolytic transfusion reaction - intra vs extravscular hemolysis according to clinical manifestation

hemoglobinuria (intrav hemolysis)
jaundice (extravascular hemolysis)

94

Immune complex Hypersensitivity reaction can associated with

1. vasculitis
2. Systemic manifestations

95

Arthus reaction - time

3-6 h

96

anaphylactic and atopic (type I) hypersensitivity reaction - main vasoactive amine and where it acts

Histamamine --> postcapillary venules

97

Hashimoto thyroditis antibodies

1. antimicrosomal
2. antithyroglobulin

98

Blood transfusion reaction - Febrile nonhemolytic transfusion reaction - clinical manifestation

1. fever
2. headaches
3. chills
4. flushing

99

antimitrochondrial - disease

primary biliary cirrhosis

100

anaphylactic and atopic (type I) hypersensitivity reaction - antibodies, cells and their binding

IgE are binded on Mast cells or basophils through Fc receptor

101

Hypersensitivity reaction type IV is cell mediated so it is not transferable by

serum