Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Immunology > Hypersensitivity reaction > Flashcards

Hypersensitivity reaction Flashcards

(101 cards)

Start Studying
1
Q

anaphylactic and atopic (type I) hypersensitivity reaction - delayed respond - cells ?

A

neutrophils and eosinophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pernicious anemia antibodies

A

antiparietal antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Lupus antibodies

A
  1. Anticardiolipine (SLE, antiphospholipid syndrome)
  2. lupus anticoagulant (SLE, antiphospholipid syndrome)
  3. Anti-dsDNA (SLE, specific, poor prognosis - renal)
  4. Anti-Smith (SLE, specific, no prognostic)
  5. anti-histone (drug induced lupus)
  6. anti-β2 glycoprotein antibodies (antiphospholipid syndrome)
  7. ANA (SLE, sensitive, nonspecific)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

eosinophil produce

A
  1. histaminase

2. Major basic protein (a helminthotoxic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Blood transfusion reaction - Febrile nonhemolytic transfusion reaction - treatment

A

acetaminophen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Anti-hemidesmosome - disease

A

bullous pemphigoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

IgA-deficiency and blood transfusion

A

IgA-deficient patients with anti-IgA IgEs are at risk for anaphylaxis if they receive blood or intravenous immunoglobulin (rare)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Anti-basement membrane - disease

A

Goodpasture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Blood transfusion reaction - anaphylactic reaction mechanism

A

severe allergic reaction.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

DM1 -anybodies

A

anti-glutamic acid decarboxylase (GAD-65) -

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

anti-Mi-2 - disease

A
  1. polymyositis

2. dermatomyositi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

direct Coomb’s test - definition and example

A

detects antibodies that have adhered to patient’s RBCs

eg. test an Rh infant of an Rh mother

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Basophil contains

A
  1. heparin (densly basophilic granules)
  2. histamine (densly basophilic granules)
  3. synthesie and release leukotrienes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

anti-Smith - disease

A

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IgA anti-endomysial

A

Celiac disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

anticardiolipine - disease

A

SLE

antiphospolypid syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Mast cells releases

A
  1. histamine
  2. tryptase
  3. eosinophil chemotactic factor
  4. heparin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Blood transfusion reaction - Febrile nonhemolytic transfusion reaction - mechanism

A

type II hypersensitivity reaction –> host antibodies against donor HLA antignes and WBCs
NO HEMOLYSIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

voltage-gated calcium channel antibodies - disease

A

Lambert Eaton

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Anti-desmoglein (anti-desmosomes) - disease

A

Pemphigus vulgaris

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

anti-CCP - disease

A

RA (more specific)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

anti-glutamic acid decarboxylase (GAD-65) - disease

A

DM1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

anaphylactic and atopic (type I) hypersensitivity reaction - test

A

skin test for specific IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Serum sickness - symptoms

A
  1. Fever
  2. Urticaria
  3. arthralgia
  4. proteinuria
  5. lymphadeonpathy
  6. splenomegaly
  7. eosinophilia
    OCCURS 5-10 DAYS AFTER ANTIGEN EXPOSURE
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Blood transfusion reaction - acute hemolytic transfusion reaction - intravascular or extravascular hemolysis?
both
26
Sjogren antibodies
1. Anti-SSA | 2. Anti-SSB (anti-Ro, anti-La)
27
Delayed (cell mediated) Hypersensitivity reaction (IV) - mechanism
sensitized T cells encounter antigen and then release cytokine (leads to macrophages activation) DOES NOT INVOLVE ANTIBODIES (vs I, II, III)
28
Anticentromere - disease
Limeted scleroderma (CREST syndrome)
29
Arthus reaction - diagnosis
immunofluorescent stating
30
dermatomyositis antibodies
1. Anti-jo 2. Anti-SRP 3. Anti-Mi-2
31
PR3-ANCA/c-ANCA - disease
granoulomatosis with polyangiitis (Wegener)
32
Blood transfusion reaction - allergic type - mechanism
type I hypersensitivity against plasma proteins in transfused blood
33
Anti-Jo-1 - disease
1. polymyositis | 2. dermatomyositis
34
Polymyositis antibodies
1. Anti-jo 2. Anti-SRP 3. Anti-Mi-2
35
Hypersensitivity reaction - types
1. anaphylactic and atopic (type I) 2. Cytotoxic (antibody mediated, type II) 3. Immune complex (type III) 4. Delayed (cell mediated, type IV)
36
Blood transfusion reaction - anaphylactic reaction - treatment
epnephrine
37
anaphylactic and atopic (type I) hypersensitivity reaction - examples
1. allergic and atopic disorder (eg. rhinitis, hay fever, eczema, hives, asthma) 2. Anaphylaxis (eg. bee sting, some food/drug allergies
38
Cytotoxic (antibody mediated) Hypersensitivity reaction - types of antibodies
IgM | IgG
39
vasculitis - antibodies
1. Microscopic polyangitis --> MPO-ANCA/p-ANCA - disease 2. eosinophilic granulomatosis with polyangitis (Churg strauus) --> MPO-ANCA/p-ANCA - disease 3. granoulomatosis with polyangiitis (Wegener) --> PR3-ANCA/c-ANCA
40
Hypersensitivity reaction type IV - test
1. patch test | 2. PPD
41
haptens are
small molecules that elicit an immune response only when attached to a large carrier (eg. protein) which may be one that also does not elicit an immune response by itself
42
Crest syndrome - antibodies
Anticentromere
43
bullous pemphigoid - antibodies
Anti-hemidesmosome
44
Arthus reaction vs serum sickness according to time and which is the MC
Arthus reaction --> 3-6h MC | serum sickness --> 5 days
45
antithyroglobulin - disease
Hashimoto
46
Anti-smooth muscle
Autoimmune hepatitis type 1
47
anti-dsDNA - disease
SLE
48
Celiac disease - antibodies
1. IgA anti-endomysial | 2. IgA anti-tissue transglumatiminase
49
Arthus reaction - mechanism
local sabacute antibody-mediated hypersensitivity reaction --> intradermal (or subcutaneous) injection into a presensitized (has circulating IgG individual leads to immune complex formation in the skin --> activation of complement --> PMN infiltration and platelet clumbing
50
Hypersensitivity reaction type IV - example of diseases (3)
1. Contact dermatitis (poison IV, nickel allergy) 2. graft-vs-host disease 3. Multiple sclerosis
51
Arthus reaction - symptoms
edema and necrosis
52
antiparietal cell - disease
pernicious anemia
53
indirect Coomb's test - definition and example
detects serum antibodies that can adhere to other RBCs | eg. test in Rh- woman for Rh+ antibodies)
54
Cytotoxic (antibody mediated) Hypersensitivity reaction - example of a nervous system disease
Guiillain Barre syndrome
55
antiphospholipase A2 receptor - disease
primary membranous neuropathy
56
Immune complex Hypersensitivity reaction - examples of diseases
1. SLE 2. Polyarteritis nodosa 3. Poststreptococcal glomerulonephritis 4. Serum sickness 5. Arthus reaction
57
Blood transfusion reaction - acute hemolytic transfusion reaction - mechanism
Type II hypersensitivity reaction --> intravascular hemolysis (ABO incompatibility) or extravascular hemolysis (host antibody reaction against foreign antigen on donor RBCs)
58
mixed connective tissue disease - antibodies
anti-U1 RNP
59
primary membranous neuropahty antibodies
Antiphospholipase A2 receptor
60
Blood transfusion reaction - acute hemolytic transfusion reaction - clinical manifestations
1. fever 2. hypotension 3. tachypnea 4. tachycardia 5. flank pain 6. hemoglobinuria (intrav hemolysis) 7. jaundice (extravascular hemolysis)
61
Serum sickness - antibodies formation takes .... (time)
5 days
62
MPO-ANCA/p-ANCA - disease
Microscopic polyangitis | eosinophilic granulomatosis with polyangitis (Churg strauus)
63
MC serum sickness is caused by
drugs (not serum) acting as haptens
64
Serum sickness - mechanism
antibodies formation to foreign proteins (take 5 days) --> immune complexes formation and deposition in membranes --> the fix complement --> tissue damage
65
Arthus reaction - examples
tetanus immunization if they are gince at the same site with too short an interval interval between immunizations (min interval us usually 5 yrs)
66
Anti-ACh receptors - disease
Myasthenia gravis
67
antimicrosomal - disease
Hashimoto
68
anti-histone - disease
drug induced lupus
69
Blood transfusion reaction - anaphylactic reaction - clinical manifestation
1. Dyspnea 2. Bronchospasm 3. Hypotension 4. Respiratory arrest 5. shock
70
Rheumatoid arthritis - antibodies
1. Rhematoid factor | 2. anti-CCP (more specific)
71
Blood transfusion reaction - types
1. allergic reaction 2. Anaphylactic reaction 3. Febrile nonhemolytic transfusion reaction 4. Acutehemolytic tranfusion reaction
72
primary biliary cirrhosis antibodies
Antimitochondrial
73
Blood transfusion reaction - allergic type - treatment
antihistamines
74
Immune complex Hypersensitivity reaction - mechanism
antigen-antibody (IgG) complexes --> activate complement --> attracts neutrophils which release lysosomal enzymes
75
Rhematoid factor?
IgM antibody that targets IgG Fc region
76
Pemphigus vulgaris - antibodies
Anti-desmoglein (anti-desmosomes)
77
anti-U1 RNP - disease
mixed connective tissue disease
78
Autoimmune hepatitis type 1 antibodies
Anti-smooth muscle
79
Lupus antigoagulant
SLE | antiphospolypid syndrome
80
Cytotoxic (antibody mediated) Hypersensitivity reaction - disease tends to be specific on
tissue or site where antigen is found
81
antinuclear (ANA) - disease
SLE (nonspecific)
82
Anti-SRP1 - disease
1. polymyositis | 2. dermatomyositis
83
anti-TSH receptor
Graves disease
84
IgA anti-tissue transglumatiminase
Celiac disease
85
anti-β2 glycoprotein antibodies - disease
antiphospholipid syndrome
86
Anti-SCL-70 (anti-DNA topoisomerase I)
diffuse scleroderma
87
diffuse scleroderma antibodies
Anti-SCL-70 (anti-DNA topoisomerase I)
88
Anti-SSB (anti-Ro, anti-La) - disease
Sjogren syndrome
89
Cytotoxic (antibody mediated) Hypersensitivity reaction - mechanism
IgM, IgG bind to fixed antigen on "enemy" cell --> complement activation --> membrane attack complex (MAC) --> a. opsonizaiton and phagoyctosis b. complement and Fc-mediated inflammation c. antibody-mediated cellular dysfunction
90
anaphylactic and atopic (type I) hypersensitivity reaction - mechanism
Antigen induce the formation of IgE (through Th2 and Il-4) --> Reexposure --> Free antigen cross-links IgE on presenting mast cells and basophils, triggering immediate release of vasoactive amines that act at postcapillary venules (eg. histamine). Rapidly reaction because of preforemed antibody --> Delayed response due to production of arachindoinc acid metabolites (eg. Leukotrienes) --> neutrophils and eosinophils
91
Blood transfusion reaction - allergic type - clinical presentation
1. urticaria 2. pruritus 3. wheezing 4. fever
92
Anti-SSA - disease
Sjogren syndrome
93
Blood transfusion reaction - acute hemolytic transfusion reaction - intra vs extravscular hemolysis according to clinical manifestation
hemoglobinuria (intrav hemolysis) | jaundice (extravascular hemolysis)
94
Immune complex Hypersensitivity reaction can associated with
1. vasculitis | 2. Systemic manifestations
95
Arthus reaction - time
3-6 h
96
anaphylactic and atopic (type I) hypersensitivity reaction - main vasoactive amine and where it acts
Histamamine --> postcapillary venules
97
Hashimoto thyroditis antibodies
1. antimicrosomal | 2. antithyroglobulin
98
Blood transfusion reaction - Febrile nonhemolytic transfusion reaction - clinical manifestation
1. fever 2. headaches 3. chills 4. flushing
99
antimitrochondrial - disease
primary biliary cirrhosis
100
anaphylactic and atopic (type I) hypersensitivity reaction - antibodies, cells and their binding
IgE are binded on Mast cells or basophils through Fc receptor
101
Hypersensitivity reaction type IV is cell mediated so it is not transferable by
serum

Immunology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions