Hypersensitivity types

Question 1

Mast cells and basophils releasing cytokines that induce cellular inflammation is seen in…

Answer 1

Delayed phase of Type I hypersensitivity reaction

Question 2

Type I hypersensitivity reaction immediate phase involves…

Answer 2

immediate release of vasoactive amines at postcapillary venules

Question 3

Reaction of type I hypersensitivity reaction occurs rapidly because of…

Answer 3

preformed antibodies

Question 4

Anaphylatic and atopic reaction is what type of hypersensitivity reaction

Answer 4

Type I

Question 5

What antibody cross-links on presensitized mast cells and basophils

Answer 5

IgE

Question 6

IgE cross-linking on presensitized mast cells and basophils triggers…

Answer 6

immediate release of histamine at postcapillary venules

Question 7

Food, drug, or bee stings causing anaphylaxis are examples of…

Answer 7

Type I hypersensitivity reaction

Question 8

Skin test or blood test like ELISA for allergen-specific IgE illicits what hypersensitivity reaction?

Answer 8

Type I

Question 9

Test that detects antibodies attached to RBC surface

Answer 9

Direct Coombs test

Question 10

Test that detects presence of unbound antibodies in serum

Answer 10

Indirect Coombs test

Question 11

Direct and Indirect Coombs test are what type of hypersensitivity reaction

Answer 11

Type II

Question 12

Antibodies that bind to cell-surface antigens causing cellular destruction, inflammation, and dysfunction is what type of hypersensitivity reaction?

Answer 12

Type II

Question 13

Phagocytosis and/or activation of complement causing cellular destruction is what type of hypersensitivity reaction?

Answer 13

Type II

Question 14

Antibody-dependent cellular cytotoxicity is what type of hypersensitivity reaction

Answer 14

Type II

Question 15

Autoimmune hemolytic anemia is what type of hypersensitivity reaction

Answer 15

Type II

Question 16

Immune thrombocytopenic purpura is what type of hypersensitivity reaction

Answer 16

Type II

Question 17

Transfusion reactions are what type of hypersensitivity reaction

Answer 17

Type II

Question 18

Hemolytic disease of the newborn is what type of hypersensitivity reaction

Answer 18

Type II

Question 19

Binding of antibodies to cell surfaces causing activation of complement system and Fc receptor-mediated inflammation is what type of hypersensitivity reaction

Answer 19

Type II

Question 20

Goodpasture syndrome, Rheumatic fever, and hyperacute transplant rejection are what type of hypersensitivity reactions

Answer 20

Type II

Question 21

Antibodies binding to cell surface receptros causing abnormal blockade or activation of downstream process is what type of hypersensitivity reaction

Answer 21

Type II

Question 22

Myesthenia gravis, Graves disease, and pemphigous vulgaris are what type of hypersensitivity reactions

Answer 22

Type II

Question 23

Antigen-antibody-complement immune complex is what type of hypersensitivity reaction

Answer 23

Type III

Question 24

SLE, Polyarteritis nodosa, Poststreptococcal glomerulonephritis are what type of hypersensitivity reactions

Answer 24

Type III

Question 25

Type III hypersensitivity reactions involve what type of cells?

Answer 25

Antigen-antibody-complement complex that attracts neutrophils that release lysosomal enzymes

Question 26

Arthus reaction are caused by what?

Answer 26

Antigen-antibody complexes

Question 27

Immune complex disease in which antibodies to foreign proteins are produced and can take 5-10 days

Answer 27

Serum sickness

Question 28

Fever, urticaria, arthralgia, proteinuria, lymphadenopathy after antigen exposure is seen in what?

Answer 28

Serum sickness, a type III hypersensitivity reaction

Question 29

Edema, necrosis, and activation of complement after an intradermal injection causing and immune-complex formation is seen in what?

Answer 29

Arthus reaction, at type III hypersensitivity reaction

Question 30

Immune complexes deposit in membranes that fix complement is seen in what?

Answer 30

Serum sickness, a type III hypersensitivity reaction

Question 31

Type IV hypersensitivity reaction involving direct cell cytotoxicity involves what cell types?

Answer 31

CD8+ cytotoxic T-cells

Question 32

Delayed-type IV hypersensitivity reaction involves what cell types?

Answer 32

CD4+ helper T-cells

Question 33

Mechanism of macrophage activation in delayed-type IV hypersensitivity reaction

Answer 33

CD4+ helper T-cells encounter antigen, release cytokines causing inflammation and macrophage activation

Question 34

Hypersensitivity reaction that does not involve antibodies

Answer 34

Type IV

Question 35

Which hypersensitivy reactions involve antibodies

Answer 35

Type I, II, III

Question 36

Diabetes mellitus type I is what type of hypersensitivy reaction

Answer 36

Type IV, direct cell cytotoxicity

Question 37

Contact dermatitis like poisin ivy or nickel allergy is what type of hypersensitivy reaction

Answer 37

Type IV, delayed

Question 38

Graft-vs-host disease is what type of hypersensitivy reaction

Answer 38

Type IV, delayed