I and D week 3

Question 1

Deficiencies in complement, phagocytes, B cells and T cells cause what kinds of susceptibilities respectively?

Answer 1

Deficiency Susceptibility
Early Complement –> Encapsulated Bacteria
Late Complement –> Neisseria infections
Phagocytes –> Bacteria, fungi and molds
B-cells –> Bacteria
T-cells –> Viruses, fungi and bacteria

Question 2

Absence of C1 inhibitor causes _____________

Answer 2

Absence of C1 inhibitor causes hereditary angioedema

Question 3

Absence of Factor H of Factor I leads to ___________

Answer 3

Absence of Factor H leads to atypical HUS

Question 4

Medication-induced neutropenia causes ___________

Answer 4

Deficiency in neutrophils –> many bacterial infections

Question 5

Chronic Granulomatous Disease cause problems with ___________

Answer 5

Chronic Granulomatous Disease cause problems with catalase (+) organisms

Question 6

Which steps of cell migration do LAD I and LAD II affect? And what does it lead to?

Answer 6

LAD II affects the rolling step with the selectins
LAD I affects the adhesion step with the integrins

Can’t get into tissue (stays in peripheral so will be high on labs) → recurrent skin infections but NO PUS

Question 7

C3NeF is an antibody that can be directed toward the C3bBb in the alternative pathway causing an increase in the half-life of C3bBb → more C3 → overactive immune response/unwanted response.
A deficiency in C3NeF causes __________

Answer 7

Causes membranoproliferative glomerulonephritis type II (MPGN II) → kidney dysfunction due to deposits of immune complexes in the glomeruli

Question 8

While deficiencies in ___________ and ____________ inhibit the formation of C3 convertase, deficiencies in __________ inhibits the MAC complex.

Answer 8

While deficiencies in MCP (CD46) and Decay Accelerating Factor (DAF) inhibit the formation of C3 convertase, deficiencies in CD59 inhibits the MAC complex.