I-P

Question 1

discovered the anti-i

Answer 1

Marsh and Jenkins

Question 2

is a branched carbohydrate

Answer 2

I

Question 3

a linear carbohydrate

Answer 3

i

Question 4

I and i is both formed due to activity of

Answer 4

glycosyl transferases

Question 5

are rich in i (| is undetectable)

Answer 5

Infant RBCs

Question 6

are rich in “I” (i is trace)

Answer 6

Adult RBCs

Question 7

adults that retains their “i”
antigen

Answer 7

“Adult-i”

Question 8

precursor for the synthesis of ABO and Lewis antigens

Answer 8

l and i antigens

Question 9

“¡” antigen activity is defined by

Answer 9

at least two repeating N-acetyllactosamine units in linear form

Question 10

IGnt gene (GCNT2) - found on chromosome?

Answer 10

chromosome 6p24

Question 11

Encodes the N-acety glucosaminy transterase
that adds N- Acetylglucosamine (G1cNAc) to form the branches

Answer 11

IGnt gene (GCNT2)

Question 12

Increased “i” antigen expression

Answer 12

Acute Leukemia
Hypoplastic anemia
Megaloblastic anemia
Sideroblastic anemia
Thalassemia
Sickle cell disease
Paroxysmal nocturnal hemoglobinuria
Chronic hemolytic anemia

Question 13

common autoantibody found in virtually all sera

Answer 13

Anti-l

Question 14

A benign antibody - not associated with in-vivo RBC destruction

Answer 14

Anti-l

Question 15

Anti-I is detected by

Answer 15

Detected by polyspecific AHG reagent