I - Topnotch Pharma Flash Cards - Autonomics Preview

Pathology PLE 2015 > I - Topnotch Pharma Flash Cards - Autonomics > Flashcards

Flashcards in I - Topnotch Pharma Flash Cards - Autonomics Deck (49):
1

rapidly hydrolyzed by AChE

Acetylcholine (TOPNOTCH)

2

resistant to AChE

Betanechol (TOPNOTCH)

3

for Bladder and bowel atony

Betanechol (TOPNOTCH)

4

Nonselective muscarinic and nicotinic agonist , used topically for glaucoma treatment

Carbachol (TOPNOTCH)

5

Partial muscarinic agonist; used for treatment of Glaucoma, Sjogren's syndrome and Sicca syndrome

Pilocarpine (TOPNOTCH)

6

Adverse Effects of Acetylcholine

CNS stimulation, miosis, cyclospasm, brochoconstriction, excessive GI and GU smooth muscle contraction, increased secretory activity of sweat gland, airways etc, vasodilation (TOPNOTCH)

7

activates autonomic post ganglionic neurons (both sympathetic and parasympathetic) and skeletal muscle neuromuscular end plants

Nicotine(TOPNOTCH)

8

used exclusively for smoking cessation

Varenicline (TOPNOTCH)

9

for Myasthenia gravis diagnosis (Tensilon test)

Edrophonium (TOPNOTCH)

10

for Myasthenia gravis treatment; reversal of nondepolarizing muscular blockade

Neostigmine (TOPNOTCH)

11

Long Acting Cholinesterase Inhibitors used as Scabicide and Insecticide

Malathion, Parathion (TOPNOTCH)

12

Competitively blocks all muscarinic receptors, antagonizes histamine and serotonin ; for motion sickness, dec. acid secretion in the GIT

Scopolamine (TOPNOTCH)

13

DOC for organophosphate poisoning

Atropine (TOPNOTCH)

14

for bradycardia, hypersalivation and to decrease airway secretion during general anesthesia

Atropine (TOPNOTCH)

15

Mydriatic, cycloplegic in eye examinations

Homatropine, Cyclopentolate, Tropicamide (TOPNOTCH)

16

Competitive nonselective antagonist at muscarinic receptors ; for BA and COPD, not as effective as SABAs but less tachycardia and arrhythmia

Ipratropium, Tiotropium (TOPNOTCH)

17

Nonselective muscarinic antagonist which reduces detrussor smooth muscle tone spasms

Oxybutinin (TOPNOTCH)

18

for decreasing urgency in mild cystitis and dec. bladder spasm after urologic surgery

Oxybutinin (TOPNOTCH)

19

Usual antidote for early stage (48h) cholinesterase inhibitor poisoning, Must be administered before 6-8 hours of organophosphate bond with cholinesterase occurs

Pralidoxime (TOPNOTCH)

20

Competitively blocks all Nn nicotinic Ach receptors ; for Hypertensive emergencies (obsolete)

Hexamethonium, Mecamylamine, Trimethaptan (TOPNOTCH)

21

DOC for Anaphylaxis

Epinephrine (TOPNOTCH)

22

used for Cardiac arrest, anaphylaxis, asthma, COPD, Hemostasis

Epinephrine (TOPNOTCH)

23

for cardiogenic Shock and heart failure

Norepinephrine (TOPNOTCH)

24

causes vasodilation in splanchnic and renal blood vessels ; for cardiogenic Shock and heart failure

Dopamine (TOPNOTCH)

25

Beta nonselective sympathomimetic, for Asthma

Isoproterenol (TOPNOTCH)

26

SE: Rebound nasal congestion, hypertension, stroke, MI

Phenylephrine (TOPNOTCH)

27

A2 agonist, for Hypertension, Cancer pain, opioid withdrawal

Clonidine (TOPNOTCH)

28

Sedation, rebound hypertension, dry mouth

Clonidine (TOPNOTCH)

29

Sedation, positive Coomb's test (Hemolytic anemia)

Methyldopa (TOPNOTCH)

30

A2 agonist; reserved for ophthalmologic use in glaucoma for reduction of intraocular pressure

Apraclonidine, Brimonidine (TOPNOTCH)

31

B1 agonist, for cardiogenic shock and acute heart failure

Dobutamine (TOPNOTCH)

32

DOC as Asthma reliever, Rapid development of tolerance

Albuterol/Salbutamol (TOPNOTCH)

33

D1 agonist, for Hypertension

Fenoldopam (TOPNOTCH)

34

D2 agonist, restores dopamine actions in the CNS for Parkinson's disease, prolactinemia

Bromocriptine (TOPNOTCH)

35

Irreversibly blocks A1 and A2 receptors resulting to indirect baroreflex activation

Phenoxybenzamine (TOPNOTCH)

36

Reversible A1 and A2 receptor antagonist, for Pheochromocytoma and Rebound hypertension

Phentolamine (TOPNOTCH)

37

Blocks A1, for Benign Prostatic Hyperplasia, Hypertension

Prazosin, Doxazosin, Terazosin (TOPNOTCH)

38

Slightly selective A1a blockade causing relaxation of prostatic smooth muscles > vascular smooth muscle ; for BPH

Tamsulosin (TOPNOTCH)

39

Beta blockade > A1 blockade

Labetalol (TOPNOTCH)

40

Blocks B1 and B2 receptors

Propranolol, Nadolol, Timolol (TOPNOTCH)

41

B1 > B2 blockade

Metoprolol, Atenolol, Alprenolol, Betaxolol, Nebivolol (TOPNOTCH)

42

B1, B2 with intrinsic sympathomimetic (partial agonist) effect

Pindolol, Acebutolol, Carteolol, Bopindolol, Oxprenolol, Celiprolol, Penbutolol (TOPNOTCH)

43

Beta blockade > A1 blockade

Carvedilol, Medoxalol, Bucindolol, Labetalol (TOPNOTCH)

44

B1 > B2 blockade; for rapid control of BP and arrhythmias, thyrotoxicosis and myocardial ischemia intraoperatively ; for Supraventricular tachycardia

Esmolol (TOPNOTCH)

45

BB with direct vasodilating effect

Nebivolol (TOPNOTCH)

46

BB with local anesthetic effect

Propranolol (TOPNOTCH)

47

BB which is safe in pregnant patients

Labetalol (TOPNOTCH)

48

Mydriasis without cycloplegia

Phenylephrine (TOPNOTCH)

49

Cholinesterase Inhbitors with poor lipid solubility, oral, DOA: 30min-2h

Neostigmine (TOPNOTCH)