IBD clinical Flashcards Preview

GI > IBD clinical > Flashcards

Flashcards in IBD clinical Deck (15)
Loading flashcards...
1

Difference between Crohn's and UC clinical presentation?

Crohn's: abdominal pain and perianal disease
UC: bleeding and diarrhoea

2

Best established risk for IBD disease development?

Family history

3

Gene linked with Crohn's

NOD2/CARD15

4

Th cells and Crohn's/UC

Crohn's is a Th1 mediated disease
UC is mixed: Th1/Th2 mediated disease/NKTC

5

Smoking and crohn's

Smoking aggravates Crohn's - Andrew should not smoke
Smoking protects againts UC

6

Inflamamtion is limited to mucosa and submucosa?

UC
Crohn's is transmural

7

Proctitis

Proctitis = inflammation of the rectum only
Pancolitis: inflammation of the whole large intestine

8

Determining severity of UC?

Determined by DISEASE EXTENT + SEVERITY:
Diarrhoea + bleeding
Increased bowel frequency (HOW OFTEN?)
Urgency
Tenesmus
Incontinence
Night rising (this will be why we always have to ask lol)
Lower abdo pain (esp. LIF)
(proctitis can cause constipation)

9

Truelove and Witt Criteria for severe ulcerative colitis?

>6 bloody stools/24 hour
+
1 or more of
Fever (>37.8°C)
Tachycardia (>90/min)
Anaemia (Haemoglobin 30mm/hr)

(FATE)

10

What will a plain AXR show in UC?

Stool distribution:
Absent in inflammed colon

Mucosal oedema / ‘thumb-printing’

Toxic megacolon:
Transverse >5.5cm
Caecum >9cm

11

Endoscopy appearance of UC?

Granular mucosa
Contact bleeding
Loss of vessel pattern

12

Increased chance of which type of cancer in UC?

Increased chance of colo-rectal cancer

13

What does extensive colitis?

Extensive colitis (to beyond splenic flexure) is risk for colorectal cancer and require surveillance after 10 years of disease

14

PSC is associated with UC. Give some symptoms?

Most asymptomatic OR itch, rigors

15

Cancer associated with PSC?

Cholangiocarcinoma