Ibuprofen Flashcards
Therapeutic Classification
Analgesic, anti-inflammatory, antipyretic
Pharmacologic Classification
NSAID
Pregnancy Category
B (1st and 2nd trimester), D (third trimester)
Mechanism of Action
o Inhibits COX-1 and COX-2, which block prostaglandin synthesis and modulate T-cell function
o Inhibits inflammatory cell chemotaxis
o Decreases the release of superoxide radicals
o Increases scavenging of superoxide radicals at inflammatory sites.
Indications
o Relief of fever and mild to moderate pain associated with chronic symptomatic rheumatoid arthritis (RA) and osteoarthritis
o Myalgia, headache, dental pain, and dysmenorrhea
Contraindictions
o Allergy to aspirin or other NSAIDs
o PUD, bleeding abnormalities and perioperative pain related coronary artery bypass graft (CABG)
o Severe hepatic impairment
Precautions
o Hypertension, history of GI bleeding, diabetes mellitus, impaired renal or hepatic function
o Heart failure, serious HTN, or history of stroke or MI
o Diminished respiratory function in children with asthma
o Can interfere with cardiac drugs.
o Stroke can use aspirin not ibuprofen
Drug Interactions
o Oral anticoagulants can increase risk of bleeding
o Ibuprofen may increase toxicity of digoxin, lithium, or methotrexate
o Other NSAIDs, alcohol, corticosteroids may cause serious adverse GI events
o Reduced antihypertensive action of diuretics beta blockers and angiotensin-converting enzyme (ACE) inhibitors
o Feverfew, garlic, ginger, gingko may increase risk of bleeding
Adverse Effects
o Bleeding, anorexia, heartburn, nausea, vomiting, constipation or diarrhea, dizziness, headache, drowsiness and light-headedness, polyuria, azotemia, cystitis, hematuria, increased creatinine and blood urea nitrogen (BUN) levels
Serious Adverse Effects
o Hypotension, CHF, peripheral edema, occult blood loss, aplastic anemia, leukopenia, decreased hemoglobin and hematocrit, increased aspartate transaminase (AST) and alanine transaminase (ALT), renal impairment, including acute renal failure.
Nursing Responsibilities
o Notify the presciber before therapy if the pt has a hisoty of PUD, bleeding abnormalities and perioperative pain related to CABG,
o Monitor for cardiac responses and fluid retention
o Monitor BUN and creatinine levels
o Assess complete blood count (CBC) and liver function studies, report abnormal levels
Patient Family Teaching
o Notify the health care provider of blood in vomit, black tarry stools, coffee grounds emesis, or GI discomfort
o Do not take products containing aspirin or other analgesics
o Do not drink alcohol
o Take with food or milk
o Immediately report unusual bruising
