ID

Question 1

Which Abx are time dependent?

Answer 1

Beta-lactams

Question 2

Which Abx are concentration-dependent?

Answer 2

Aminoglycosides, quinolones, dapto

Question 3

MOA of macrolides?

Answer 3

Binds to 50s

Question 4

BBW of aminoglycosides?

Answer 4

Nephro, oto, and neurotoxicity

Question 5

Aztreonam covers gram (positive/negative)

Answer 5

Negative

Question 6

Does Aztreonam cover MRSA?

Answer 6

No

Question 7

Does Aztreonam cover Pseudo

Answer 7

Yes

Question 8

Which carbapenem covers for MRSA?

Answer 8

None

Question 9

Which carbapenem covers for Pseudo?

Answer 9

All but Ertapenem

Question 10

Which cephalosporin covers for Pseudo?

Answer 10

Cefepime (4th gen) and Ceftazidime (3rd gen)

Question 11

What is the only beta-lactam that covers for MRSA?

Answer 11

Ceftaroline

Question 12

Aminoglycosides cover for gram (positive/negative)

Answer 12

Negative, unless they are used in synergy with beta-lactam or vanco

Question 13

What are the respiratory quinolones?

Answer 13

MLG

Question 14

Which quinolones cover for Pseudo?

Answer 14

Cipro + levo

Question 15

Which quinolone covers for MRSA?

Answer 15

Delafloxacin

Question 16

AE of macrolides?

Answer 16

QT prolongation + hepatotoxicity

Avoid use with lovastatin/simvastatin w/ clarithromycin or erythromycin

Question 17

MOA of tetracycline

Answer 17

Binds to 30s

Question 18

Do aminoglycosides cover for MRSA?

Answer 18

No

Question 19

Do aminoglycosides cover for Pseudo?

Answer 19

Yes

Question 20

MOA of clindamycin?

Answer 20

Binds to 50s

Question 21

Clindamycin has gram (positive/negative) coverage

Answer 21

Gram positive + anaerobes

Question 22

Generic of Omnicef?

Answer 22

Cedinir

Question 23

Which Abx cover B. fragilis?

Answer 23

1. Flagyl
2. BL + BLi
3. Cefotetan, cefoxitin
4. Carbapenems

Question 24

DOC for treating Acineobacter?

Answer 24

Merrem

Question 25

Which Abx decrease seizure threshold?

Answer 25

BL + quinolones

Question 26

Which Abx cover atypicals?

Answer 26

Zithromax, tetracyclines, quinolones

Question 27

When do you stop Abx prior to surgery?

Answer 27

1hr for Ancef or cefuroxime 2hrs if quinolone or vanco

Question 28

DOC for acute otitis media?

Answer 28

Amoxicillin or Augmentin ~90mg/kg/day

Question 29

DOC for COPD exacerbation?

Answer 29

Augmentin

Question 30

DOC for outpatient CAP?

Answer 30

BL + Macrolide/Doxy oooor respiratory quinolone monotherapy One of those components are only needed if they have no comorbidities

Question 31

DOC for inpatient CAP?

Answer 31

BL + macrolide/respiratory FQ

Question 32

Latent TB tx?

Answer 32

R/I once weekly for 12 weeks (daily for rifampin and isoniazid) Rifampin daily for 4 months INH daily for 6 or 9 months in pregnant women

Question 33

Active TB tx?

Answer 33

RIPE for 2 months R/I for 4 months

Question 34

RIPE Which one causes orange-red discoloration?

Answer 34

Rifampin

Question 35

RIPE Which one causes peripheral neuropathy?

Answer 35

Isoniazid

Question 36

RIPE Which one requires the use of Vit. B6?

Answer 36

Isoniazid to decrease peripheral neuropathy

Question 37

RIPE Which one causes optic neuritis?

Answer 37

Ethambutol

Question 38

DOC for infective endocarditis?

Answer 38

Vary, but needs 4-6 weeks of treatment

Question 39

DOC for infective endocarditis dental prophylaxis?

Answer 39

Amoxicillin 2g

Question 40

DOC for SBP?

Answer 40

Ceftriaxone for 5-7 days

Question 41

DOC for SBP ppx?

Answer 41

Bactrim or Cipro

Question 42

DOC for impetigo? (yellow crusting around mouth)

Answer 42

Cephalexin

Question 43

DOC for folliculitis/furuncles/carbuncles?

Answer 43

Systemic? Use Cephalexin If already used, bactrim or doxy works too

Question 44

DOC for mild cellulitis

Answer 44

Cephalexin

Question 45

DOC for purulent abscesses?

Answer 45

Bactrim or doxy

Question 46

DOC for severe puruelent SSTI

Answer 46

Vanco or Dapto or Zyvox

Question 47

DOC for necrotizing fascitis?

Answer 47

Vanco + BL

Question 48

DOC for bacteruria in pregnant patients?

Answer 48

Augmentin or oral cephalosporin

Question 49

DOC for traveler's diarrhea + blood?

Answer 49

Zithromax

Question 50

DOC for syphillis?

Answer 50

Bicillin LA 2.4mill

Question 51

DOC for late latent or teriary?

Answer 51

Bicillin LA 2.4mill x 3 weeks

Question 52

DOC for neuro or congenital syphillis?

Answer 52

Penicillin G aqueous, up to 24 millions units daily x 10-14 days

Question 53

DOC for gonorrhea?

Answer 53

Ceftraixone

Question 54

DOC for Chlmaydia?

Answer 54

Doxy or Zithromax

Question 55

DOC for rickettsial diseases?

Answer 55

Doxycycline generally

Question 56

DOC for traveler's diarrhea and no blood?

Answer 56

Quinolones or Rifaximin

Question 57

Rate of conventional amphotericin B?

Answer 57

Dont exceed 1.5mg/kg/day

Question 58

AE of conventional amphotericin B?

Answer 58

Mg and Potassium are depleted, nephrotoxicity, infusion related AE

Question 59

When is flucytosine utuilized?

Answer 59

In combo w/ amphotericin for cryptococcal meningitis

Question 60

Flucytocin AE?

Answer 60

Myelosuppression

Question 61

General AE of all azoles?

Answer 61

Increased LFTs, risk of QT prolongation except in isavuconazonium

Question 62

Which azole requires renal adjustments?

Answer 62

Fluconazole

Question 63

Which azole causes severe hepatotoxicity?

Answer 63

Ketoconazole

Question 64

Which azole causes HF?

Answer 64

Itraconazole

Question 65

Which azole causes visual changes and phototoxicity?

Answer 65

Voriconazole

Question 66

Which azole has SBECD vehicle in it?

Answer 66

Voriconazole and Posaconazole

Question 67

DOC for Aspergillus?

Answer 67

Voriconazole

Question 68

Which azole require an acidic environment for absorption?

Answer 68

Ketoconazole + itraconazole

Question 69

Acyclovir AE?

Answer 69

Nephrotoxicity