ID Flashcards

(142 cards)

1
Q

what are the congenital infections?

A
CHEAP TORCHES
Chicken pox
Hepatitis B, C, E
Enterovirus
Aids
Parvovirus B19
Toxoplasmosis
other (zika etc)
Rubella
CMV
HSV
every other STD
Syphilis
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2
Q

what is the most common congenital infection?

A

CMV

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3
Q

what is the most common cause of acquired hearing loss in childhood?

A

CMV

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4
Q

what are the manifestations of CMV

A

KEY- IUGR, hepatosplenomegaly, thrombocytopenia, microcephaly, periventricular calcifications SNHL, chorioretinits

general- IUGR, prematurity
skin- petechia, purpura, ecchymoses, jaundice
hematopoietic- thrombocytopenia
, anemia, splenomegaly
hepatobiliary- hyperbola, elevated ALT, hepatomegaly**
CNS- microcephaly, seizures, periventricular calcifications**
eye- Chorioretinitis, strabismus, optic atrophy, micropthlamia
ear- sensorineural hearing loss

more common presentation: thrombocytopenia, petechiae, may have hepatomegaly
severe end of the spectrum: microcephaly, Chorioretinitis, hearing loss, periventricular calcifications

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5
Q

what type of calcifications are seen with CMV? zika? toxo?

A

CMV- periventricular calcifications
Zika- subcortical calcifications
toxo- intraparenchymal calcifications
HIV- basal ganglia

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6
Q

what is the treatment for congenital CMV

A

moderate to severe (multiple manifestations or CNS involvement)- treat with oral Valganciclovir (within the first month) for 6 months
- monitor neutrophil count and ALT

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7
Q

newborn infant with microcephaly, club foot, dislocated hips, chorioretinal scars. what is the cause?

A

zika

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8
Q

what type of virus is zika

how do you get zika

A

flavivirus
mosquito- borne (aedes mosquitos)
clinical manifestations- 75-80% are asymptomatic

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9
Q

what are the features of congenital zika syndrome

A

KEY- microcephaly, brain malformations, subcortical calcifications, macular scars, contractures

microcephaly with partially collapsed skull
thin cerebral cortices with subcortical calcifications
macular scarring with focal pigmentary retinal mottling
congenital contractures (arthrogryposis, club foot, congenital hip dislocation)
early hypertonia

Neuroimaging: diffuse, subcortical calcifications
ventriculomegaly
hypoplasia of corpus callous
decreased myelination
cerebellar vermis hypoplasia
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10
Q

what is the congenital anomaly risk of zika in pregnancy?

A

5-10% overall

higher risk in first trimester versus 3rd

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11
Q

how do you make an antenatal diagnosis of zika?

A

serology (IgM, IgG, PRNT)
- PRNT is confirmatory test
have to do Dengue serology at the same time
PCR in blood and urine
- remains positive for 3-7d after symptom onset

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12
Q

what is the workup for zika in a newborn

A

serology
- IgM and IgG, dengue IgM and IgG
if positive then PRNT
(zika IgM on CSF)

PCR
- placental and umbilical cord tissue
- serum, urine, CSF (if LP done)
do not use cord blood due to possible contamination with maternal blood

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13
Q

how is congenital zika virus confirmed

A

zika PCR in any specimen from child
highly likely
- detection of zika by PCR from placenta
- zika IgM reactive in baby

positive IgG or PRNT may reflect transplacental maternal antibody

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14
Q

newborn with maculopapular rash (including soles), microcephaly, Chorioretinitis, hepatosplenomegaly, bony changes. what is the most likely diagnosis?

A

syphilis

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15
Q

what are the manifestations of congenital syphilis

A

Main ones- snuffles (often bloody), pseudo paralysis, rash involving palms and soles, body changes

general- prematurity, IUGR FTT
mucocutaneous- snuffles **, maculopapular rash followed by desquamation, blistering and crusting, condyloma late
rediculoendothelial- hepatosplenomagly, lymphadenopathy
hematologic- Coombs negative hemolytic anemia, thrombocytopenia
skeletal- pseudo paralysis, oseochonritis diaphysial periostitis, demineralization.destruction of proximal tibia metaphysis, osteitis
neurologic- aseptic meningitis, hydrocephalus, cranial nerve palsies
eyes- salt and pepper chorioretinitis

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16
Q

late onset manifestations of syphilis

prob not that impt

A
saddle nose deformity
hutchinson's teeth
mulberry molars
ragades(linear scars(
saber shins
global developmental delay
hydrocephalus
seizures
cranial nerve palsies
sensorineural hearing loss
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17
Q

when should you evaluate for syphilis (6) * impt to know

A
  1. signs and symptoms of congenital syphilis
  2. mother not treated or treatment not adequately documented
  3. mother treated with non-penicillin regimen
  4. mother treated within 30 days of child’s birth
  5. less than 4 fold drop in mother’s non-treponema titre or not assessed or documented
  6. mother had relapse or reinfection after treatment
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18
Q

what is the evaluation for a child with suspected congenital syphilis (7)

A

physical exam (must have audiologic testing and an eye exam)
CBC
LFTs
serology
lumbar puncture- to see if there is CNS disease (if so must be repeated in 6 months)
skeletal survey (primarily looking at long bones)
direct detection- dark field microscopy/direct fluorescent Ab

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19
Q

what is the treatment of congenital syphilis

A

10-14 days of IV Pen G

asymptomatic, mother adequately treated- close clinical follow-up

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20
Q

two month old term infant, asymptomatic at birth. Now hypotonic and macrocephalic. what is the cause?

A

toxoplasmosis

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21
Q

what are 3 investigations to confirm toxoplasmosis?

A

serology- IgM/IgG/ IgA
PCR on CSF, serum, urine
placental pathology

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22
Q

what is seen on LP with toxoplasmosis?

A

lymphocytic pleocytosis

elevated CSF protein (often very high)**

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23
Q

what is the classic triad for toxoplasmosis?

A

HCC

hydrocephalus
cerebral calcifications (intraparenchymal calcifications)
chorioretinitis

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24
Q

toxoplasmosis in 3rd trimester- how do they present?

A

untreated the majority will go on to develop disease

Chorioretinitis most common manifestation

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25
what is the treatment of confirmed congenital toxoplasmosis?
pyrimethamine+ sulfadiazine+ leucovorin x 12 months - frequent monitoring of neutrophil count - steroids for eye disease and passively hydrocephalus - VP shunt for hydrocephalus
26
how do you diagnose toxoplasmosis:
serology- IgM and IgA can be falsely negative in early infancy PCR- CSF, blood, urine or tissue samples
27
cicatrical scars/limb hypoplasia in seen with what congenital infection?
congenital varicella
28
what are the clinical manifestations of congenital varicella?
KEY- microcephaly, cicatrical scars, limb hypoplasia, Microphthalmia, GERD skin- cicatrical scars**, skin loss, contractors MSK- limb hypoplasia**, equinovarus, abnormal/absent digits eye- Microphthalmia, cataract, Chorioretinitis CNS- mental retardation, seizures, microcephaly, bulbar palsy GI- GERD, duodenal stenosis, microcolon, barret's esopahgus GU- poor or absent bladder sphincter function IUGR
29
what is the risk of congenital varicella syndrome if maternal VZV during first 20 weeks of gestation?
1%
30
infant disease by timing of maternal infection with varicella: first and second trimester third trimester perinatal (5d before or 2 d after)
first and second trimester- congenital varicella syndrome third trimester- herpes zoster in infancy or childhood perinatal- disseminated neonatal varicella
31
what is given to mother with exposure to varicella in pregnancy if IgG negative
VZIG within 10 days of exposure | if develops chicken pox= acyclovir
32
what is the classic triad for congenital rubella syndrome?
"CPS" cataract PDA SNHL
33
what are the clinical features for congenital rubella syndrome
KEU- IUGR, blueberry muffin rash, hepatosplenomegaly, cataract, bony lucencies, PDA, SNHL ``` early manifestations: low birth weight hepatosplenomegaly, lymphadenopathy blueberry muffin rash ** hemolytic anemia thrombocytopenia bony lucencies ** (celery stalk appearance) ``` ``` permanent: SNHL cataract, sal and pepper retinitis, microphthalmia PDA GDD, seizures ```
34
what infection is associated wth blueberry muffin rash?
congenital rubella
35
when do we screen for GBS in mom?
35-37 weeks gestation
36
what are the indications for intrapartum antibiotic prophylaxis
mom GBS + GBS status unknown and any of the following: - previous infant with GBS disease - intrapartum fever - membranes ruptured >18 hours - delivery <37 weeks - GBS bacteriuria during current pregnancy
37
what is the appropriate antibiotic for mom for GBS prophylaxis?
penicillin or ampicillin if mild penicillin allergy: cefazolin (considered adequate prophylaxis for baby) severe: clindamycin or vancomycin (NOT adequate prophylaxis for baby) does not prevent late onset GBS disease
38
what are the risk factors for early onset sepsis in term neonates? (5)
- previous infant with GBS disease - intrapartum fever - membranes ruptured >18 hours - maternal intrapartum GBS colonization during current pregnancy - GBS bacteriuria during current pregnancy
39
what are the most common bacterial pathogens in infants 0-28d 29-90d 3-36mo
0-28d: GBS, E.coli 29-90: GBS, E.coli 3-36 mo: Strep pneumo
40
empiric antibiotics for toxic appearing infants age 0-28 29-90 3-36mo
0-28: Amp + gent or cefotaxime 29-90: ceftriaxone+ Vanco +/- ampicillin 3-36: ceftriaxone + vanco
41
what is the treatment for suspected HSV disease isolated mucocutaneous disease disseminated, CNS
IV acyclovir 60mg/kg/day isolated mucocutaneous: 2 weeks disseminated: 3 weeks + 6 months of suppressive oral acyclovir (improves neurologic outcome for those with CNS disease) do an LP before completion of treatment to show it is negative
42
what is the workup for suspected HSV?
full septic workup PCR of vesicle fluids, blood, CSF LP
43
what infection should you think of for axillary lymph node?
bartonella henselae
44
what infection is associated with parinaud oculoglandular syndrome? what is that?
bartonella henselae | swollen cervical lymph node and ipsilateral conjunctivitis
45
4 year old with a chronically draining cervical lymph node. what is the most likely bug?
atypical mycobacterium
46
what is on your differential for chronic unilateral adenitis
non-tuberculosis mycobacteria bartonella mycobacterium tuberculosis
47
what is on your differential for acute unilateral adeninitis
staph aureus | strep pyogenes
48
what is on your differential for acute bilateral adenitis? chronic?
``` EBV CMV respiratory viruses enteroviruses adenovirus ``` ``` chronic: EBV HIV Toxoplasmosis CMV ```
49
what is the treatment for cat scratch disease (B.henselae)
azithromycin for lymphadenitis (shorten disease) doxycycline + rifampin for neuroretinitis/CNS disease * risk highest with kittens
50
when can a teenager with infectious mono return to sports?
after 3 weeks | highest risk during first 3 weeks of illness
51
what is the treatment for acute otitis media in a child <2? >2?
<2 years old: amoxicillin x 10 days | >2 years old: 5 days
52
what are the common pathogens for acute otitis media?
bacteria: strep pneumonia hemophilus influenza moraxella catarrhalis viruses
53
what are the antibiotic options for AOM?
amoxil if mild allergy to amoxil- cefuroxime, ceftriaxone severe amoxil allergy- azithro, clarithro, clinda treatment failure- amox-clav or ceftriaxone for 3 doses
54
what pathogens cause acute bacterial pneumonia
``` strep pneumo staph aureus strep pyogenies hemophilus influenza mycobacterium tuberculosis ``` mycoplasma pneumonia legionella coxiella= Q fever
55
when should you consider adding vancomycin for pneumonia?
rapidly progressing multi lobar disease or pneumatoceles
56
what is the empiric therapy for hospitalized children with uncomplicated pneumonia?
ampicillin | respiratory failure or septic shock- ceftriaxone +/- Vancomycin
57
what is the treatment for chlamydia pneumonia?
erythromycin * see eosinophilia typically presents at 3- 6 weeks
58
why is antibiotic prophylaxis not recommended for chlamydia trachomatis? what should you do? when do you treat?
due to risk of pyloric stenosis recommend close clinical follow-up PCR testing if symptoms treat if PCR testing is positive
59
what is empiric therapy for meningitis: neonate 1-3 mo >3 mo
neonate: amp+ cefotax 1-3 mo: ceftriaxone + vancomycin +/- ampicillin ceftriaxone and vancomycin
60
what bugs do we worry about for meningitis: neonate >3 mo
neonate: GBS, e.coli, listeria | >3 mo: strep pneumo, Neisseria meningitidis, hemophilus influenza type b
61
why do we consider dexamethasone for meningitis?
reduces mortality and hearing loss in meningitis due to hemophilus type and possibly strep pneumonia * has to be administered before or within 30 minutes of antibiotics
62
what is the treatment of toxic shock?
cloxacillin + clindamycin | staph aureus, GAS
63
what is the treatment for skin abscess?
incision and drainage
64
``` what is the treatment for skin abscess pending culture results? <1mo 1-3 mo >3 mo with low grade fever or no fever >3 mo significant cellulitis ```
<1 mo: IV antibiotics (Vanco +/- other agents) 1-3 mo: Septra >3mo: observe without antibiotics >3 mo: Septra + cephalexin
65
what is the treatment for Necrotizing Fasciitis
IV penicillin + clindamycin + surgery consult | associated with GAS and chicken pox
66
what bugs cause impetigo? tx?
staph aureus GAS tx: cloxacillin, cephalexin
67
when do we do chemoprophylaxis for contacts of invasive GAS disease?
only for CLOSE contacts of CONFIRMED case of SEVERE disease close contact: >4h per day or >20h per week share bed, sexual relations, direct mucous membrane contact with oral/nasal secretions severe disease: toxic shock syndrome, soft tissue necrosis, meningitis, pneumonia, other life threatening conditions
68
what are some complications of chicken pox?
pneumonia hepatitis, pancreatitis nephritis, orchitis thrombocytopenia Bacterial infections: cellulitis soft tissue abscess necrotizing fasciitis ``` Neurologic: cerebellar ataxia encephalitis reye syndrome stroke zoster (Ramsay hunt syndrome) ```
69
what are some complications of influenza? (5)
``` otitis media secondary bacterial penumonia myositis encephalopathy/encephalitis reye syndrome ```
70
what are some complications of enterovirus?
``` meningitis encephalitis acute flaccid myelitis myocarditis hepatitis ```
71
when should you consider a renal and bladder ultrasound for febrile UTI
recommended for first febrile UTI <2 years of age | VCUG is not indicated after first febrile UTI
72
what are the indications for VCUG (3)
hydronephrosis on ultrasound renal scarring recurrent febrile UTI
73
when would you consider prophylaxis for UTI?
grade IV-V VUR | if given should be reassessed after 3-6 months
74
what are the first line agents for UTI prophylaxis?
Septra | nitrofurantoin
75
if a child has a UTI resistant to prophylactic antibiotics septra and nitrofurantoin what should you do?
STOP prophylaxis | broader spectrum agents not recommended due to risk of infection with highly resistant organisms
76
what is the treatment for dog bite or human bite? puncture wound of foot with sneakers? no sneakers
PO amox-clav IV cloxacillin + penicillin with sneakers (pseudomonas): piperacillin or ciprofloxacin +/- gentamicin no sneakers (staph aureus): po cloxacillin or keflex
77
what is the most important organism that causes severe invasive disease in patients with asplenia? other organisms of concern?
strep pneumonia Neisseria meningitidis hemophilus influenza salmonella capnocytophaga ( if they own dogs*)
78
What is the organism and vector causing lyme disease? what are 2 antibiotics for the treatment of Lyme disease?
Organism = Borrelia burgdorferi Vector = black-legged ticks: Ixodes scapularis Tx: amoxicillin, doxycycline, cefuroxime, IV ceftriaxone
79
highest rate of baby getting HSV is when mom has what type of lesion
first episode primary (first time getting a lesion)
80
when should you swab a baby when you are worried about HSV
at 24 hours | if you swab too soon it may just be transient colonization from mom
81
Mom has first episode of HSV. Babe is born vaginally or by c section after rupture of membranes. What do you do?
treat with acyclovir if swabs positive- full workup and treatment if swabs negative- treat for 10 days with IV acyclovir
82
Mom has first episode of HSV. Babe is born by c section PRIOR to rupture of membranes. What do you do?
do not need to treat empirically with acyclovir | if swabs positive- full workup and treatment
83
Mom has recurrent HSV. What do you do?
do not need to treat empirically with acyclovir | if swabs positive- full workup and treatment
84
if mom has herpes labialis what precautions (4)
avoid kissing the baby until lesions are crusted wear a mask avoid breastfeeding from breast with active lesions until crusted skin lesions should be covered in the presence of newborn
85
Mother has recurrent HSV. There were no active lesion at delivery. For how long after delivery is the infant at risk for PERINATAL transmission?
6 weeks
86
what is required to consider watchful waiting for acute otitis media
1. non-severe illness (mild otalgia, fever <39, responding to antipyretics, mild-moderate TM bulge) 2. no underlying conditions of concern 3. parents capable of recognizing signs of worsening disease
87
what is a common complication after chicken pox, especially if older than 12 or pregnant
VZV pneumonia
88
what is the most common cause of acute flaccid paralysis
enterovirus | also caused by west nile virus
89
what is the presentation of acute flaccid paralysis
acute focal limb weakness and MRI findings of mainly grey matter lesions involving one or more spinal cord segments
90
what is the most common presentation of west nile virus
asymptomatic
91
what is considered mild c. diff? moderate?severe
mild: <4 episodes of diarrhea moderate: >4 episodes severe: evidence of systemic toxicity (high grade fevers, rigors)
92
what is the treatment for mild, moderate, severe c diff
mild: stop antibiotic moderate: PO metronidazole 10-14 d Severe uncomplicated: PO vancomycin x 10-14d Severe complicated: PO vanco + IV metronidazole
93
what type of hand cleaning is required for c diff
``` sporicidal agents (chlorine-based) alcohol based hand hygiene will not work for c diff! ```
94
what is the treatment for gonorrhea
Ceftriaxone 250 mg IM in a single dose PLUS azithromycin 1 g PO in a single dose
95
Three year old boy exposed to a suspected case of pulmonary TB in the home. Clinically well, TST negative, CXR normal. How do you treat him?
Start isoniazid now; discontinue in 3 months if still clinically well and repeat TST negative
96
What is the difference between TB infection and TB disease
TB infection- positive TST | TB disease- clinical symptoms or abnormal CXR
97
who should be screened for LTBI
``` contacts of infectious case immigrants from high burden countries children who travelled/resided endemic areas for 3 or more months HIV pre-transplant pre- TNF alpha inhibitors ``` **testing for TB should not be routine
98
what is considered a positive TST if less than 5 AND high risk of TB infection
0-4mm
99
Positive TST >5mm if what conditions
* HIV infection (well) * Close contact with active contagious case (past 2 years) * Presence of fibronodulardisease on CXR(healed TB) * Organ transplant * TNF-αinhibitors * Other immunosuppressive medications (e.g. corticosteroids –equivalent of ≥15 mg/day for ≥1 month) * End stage renal disease
100
what are 4 reasons for a reactive TB skin test
Mycobacterium tuberculosis infection Non-tuberculous mycobacteria infection BCG in past Incorrect technique (measurement)
101
what are some causes of a false negative TB test (8)
``` Incorrect technique Active TB disease Immunodeficiency states Corticosteroids Young age Malnutrition Viral infections (measles, varicella, influenza) Live attenuated vaccines (measles) ```
102
what is the treatment for latent TB
Isoniazid for 9 months OR rifampin for 4 months OR isoniazid and rifampin for 3 months
103
what is the treatment for TB disease
Isoniazid Rifmapin Pyrazinamide Ethambutol
104
which TB medication requires ophthalmology assessment
ethambutol | associated with optic neuropathy (decreased visual acuity, decreased visual fields, color blindness)
105
what is a common side effect of isoniazid, rifampin and pyrazinamide
hepatotoxicty | - pyrazinamide the most likely to give you hepatotxocity
106
What is the risk of transmission of HIV in a blood transfusion?
1 in 10 million
107
The leading cause of HIV infection in women in Canada is?
heterosexual transmission
108
what is used for chemoprophylaxis after close contact diagnosed with n. meningitidis
rifampin
109
who should get the HPV vaccine
all boys and girls older than 9 years of age | regardless of sexual activity
110
who can get 2 doses of HPV vaccine instead of 3
9-14 years of age | children >/= 15 years of age or immunocompromised should get 3 doses!
111
what are 4 things that HPV vaccine prevents
``` anal cancer penile cancer vulvar cancer genital warts vaginal cancer oral cancer cervical cancer ```
112
HPV 6 and 11 are associated with what
genital warts
113
When should rotavirus vaccine be given
series needs to be completed prior to 8 months of age | first dose no later than 15 weeks!
114
up to what age should children get 2 doses of influenza vaccine
2 doses 4 weeks apart | up to 9 years of age, first year getting the vaccine
115
what age child can receive intranasal influenza vaccine
>2 y of age
116
when should Hep A post exposure vaccine be given
HepA vaccine recommended as post exposure prophylaxis (>6 months) and should be given within 2 weeks of exposure if <6 months of age or vaccine contraindications then give Hep A immunoglobulin
117
when do you testing on a baby for hep c
between 12-18 months
118
infant of HCV infected mother, what is the mode of delivery
doesn't matter! avoid invasive procedures (scalp probe) | no evidence to recommend elective c section
119
what is the management for rabies exposure
notify public health domestic animal- can be observed for 10 days to see if there are signs of rabies wild animal- euthanize and test for rabies rabies immune globulin into the wound rabies vaccine series (4-5 doses)
120
what are the indications of palivizumab?
Children < 12 months of age with CLD of prematurity who require ongoing medical therapy at the start of the RSV season Children < 12 months of age with hemodynamically significant heart disease Consider in infants < 30 weeks and < 6 months of age at the start of the RSV season Consider in infants who live in remote communities and born at < 36 weeks at the start of RSV season
121
is palivizumab recommended for children hospitalized with RSV?
No, do not need to continue palivizumab
122
what are the 3 main contraindications to breastfeeding
HIV | Human T-Lymphotropic Virus Type 1/2
123
what type of mask is required for measles?
N95 mask | it is airborne
124
what 3 viruses are airborne
measles tuberculosis varicella
125
what is the treatment for cutaneous larva migrans
albendazole
126
what is the oral rash seen with measles
koplik spots
127
how do we prevent influenza in infants <6 months of age?
to prevent influenza in infants <6 months of age, the best evidence-based strategy is to administer influenza vaccines during pregnancy.
128
Pregnant woman in contact with meningococcal meningitis. Tx:
Ceftriaxone
129
HBe Ag what does it tell you about the person
active viral replication
130
A child eats at a picnic and develops vomiting and diarrhea four hours later. What is the likely causative organism:
staph aureus | - onset between 1-6h (toxin)
131
what causes q fever
farm animals | - hepatitis, pneumonia
132
when can live vaccines be given after high dose steroids
1 month after stopping high dose steroids
133
gram positive rod in a baby suggests what bug
Listeria
134
4 indications for VZIG
1) Immunocompromised child with no evidence of immunity or history of varicella or herpes with exposure 2) Immunocompromised child with lesions suggestive of varicella 3) Pregnant with no evidence of infection or immunity 4) Baby born to a mum who gets CP 5 days prior or 2 days post delivery 5) Hospitalized preterm <28 weeks or <1000g who is exposed (regardless of maternal history) 6) Hospitalized preterm >=28 weeks who is exposed, with no maternal immunity
135
A 10 year old girl presents to your office having arrived in Canada from the Sudan 1 week ago. She complains of fever, headache and sore throat of 48 hours duration. Name 3 diagnoses on your differential
Malaria Typhoid Meningococcemia
136
What is the antibiotic treatment for acute chest syndrome
3rd generation cephalosporin + macrolide
137
The most common bug in febrile neutropenia
gram positive organisms
138
What is pertussis close contact exposure prophylaxis
azithromycin x 5 days or erythromycin x 14 days
139
What are three high-risk groups for invasive pneumococcal disease?
sickle cell disease asplenia/hyposplenia immunocompromised
140
Child with inguinal adenopathy found 1 week ago by parent while bathing Give 4 indications for biopsy
1. hard 2. matted 3. >2cm 4. increasing in size over 2 weeks 5. no resolution by 4 weeks 6. associated with fever, weight loss, hepatosplenomegaly 7. if supraclavicular node
141
what is the treatment for head lice
permethrin 1%, repeat in 7-10 days | they can return to school
142
61. An infant is born to a mother with a history of recurrent genital herpes which was not active at the time of vaginal delivery. For how long after delivery is it possible for this infant to develop herpes:
Most NHSV will present in the first 4 weeks