ID Flashcards
(142 cards)
what are the congenital infections?
CHEAP TORCHES Chicken pox Hepatitis B, C, E Enterovirus Aids Parvovirus B19
Toxoplasmosis other (zika etc) Rubella CMV HSV every other STD Syphilis
what is the most common congenital infection?
CMV
what is the most common cause of acquired hearing loss in childhood?
CMV
what are the manifestations of CMV
KEY- IUGR, hepatosplenomegaly, thrombocytopenia, microcephaly, periventricular calcifications SNHL, chorioretinits
general- IUGR, prematurity
skin- petechia, purpura, ecchymoses, jaundice
hematopoietic- thrombocytopenia, anemia, splenomegaly
hepatobiliary- hyperbola, elevated ALT, hepatomegaly**
CNS- microcephaly, seizures, periventricular calcifications**
eye- Chorioretinitis, strabismus, optic atrophy, micropthlamia
ear- sensorineural hearing loss
more common presentation: thrombocytopenia, petechiae, may have hepatomegaly
severe end of the spectrum: microcephaly, Chorioretinitis, hearing loss, periventricular calcifications
what type of calcifications are seen with CMV? zika? toxo?
CMV- periventricular calcifications
Zika- subcortical calcifications
toxo- intraparenchymal calcifications
HIV- basal ganglia
what is the treatment for congenital CMV
moderate to severe (multiple manifestations or CNS involvement)- treat with oral Valganciclovir (within the first month) for 6 months
- monitor neutrophil count and ALT
newborn infant with microcephaly, club foot, dislocated hips, chorioretinal scars. what is the cause?
zika
what type of virus is zika
how do you get zika
flavivirus
mosquito- borne (aedes mosquitos)
clinical manifestations- 75-80% are asymptomatic
what are the features of congenital zika syndrome
KEY- microcephaly, brain malformations, subcortical calcifications, macular scars, contractures
microcephaly with partially collapsed skull
thin cerebral cortices with subcortical calcifications
macular scarring with focal pigmentary retinal mottling
congenital contractures (arthrogryposis, club foot, congenital hip dislocation)
early hypertonia
Neuroimaging: diffuse, subcortical calcifications ventriculomegaly hypoplasia of corpus callous decreased myelination cerebellar vermis hypoplasia
what is the congenital anomaly risk of zika in pregnancy?
5-10% overall
higher risk in first trimester versus 3rd
how do you make an antenatal diagnosis of zika?
serology (IgM, IgG, PRNT)
- PRNT is confirmatory test
have to do Dengue serology at the same time
PCR in blood and urine
- remains positive for 3-7d after symptom onset
what is the workup for zika in a newborn
serology
- IgM and IgG, dengue IgM and IgG
if positive then PRNT
(zika IgM on CSF)
PCR
- placental and umbilical cord tissue
- serum, urine, CSF (if LP done)
do not use cord blood due to possible contamination with maternal blood
how is congenital zika virus confirmed
zika PCR in any specimen from child
highly likely
- detection of zika by PCR from placenta
- zika IgM reactive in baby
positive IgG or PRNT may reflect transplacental maternal antibody
newborn with maculopapular rash (including soles), microcephaly, Chorioretinitis, hepatosplenomegaly, bony changes. what is the most likely diagnosis?
syphilis
what are the manifestations of congenital syphilis
Main ones- snuffles (often bloody), pseudo paralysis, rash involving palms and soles, body changes
general- prematurity, IUGR FTT
mucocutaneous- snuffles **, maculopapular rash followed by desquamation, blistering and crusting, condyloma late
rediculoendothelial- hepatosplenomagly, lymphadenopathy
hematologic- Coombs negative hemolytic anemia, thrombocytopenia
skeletal- pseudo paralysis, oseochonritis diaphysial periostitis, demineralization.destruction of proximal tibia metaphysis, osteitis
neurologic- aseptic meningitis, hydrocephalus, cranial nerve palsies
eyes- salt and pepper chorioretinitis
late onset manifestations of syphilis
prob not that impt
saddle nose deformity hutchinson's teeth mulberry molars ragades(linear scars( saber shins global developmental delay hydrocephalus seizures cranial nerve palsies sensorineural hearing loss
when should you evaluate for syphilis (6) * impt to know
- signs and symptoms of congenital syphilis
- mother not treated or treatment not adequately documented
- mother treated with non-penicillin regimen
- mother treated within 30 days of child’s birth
- less than 4 fold drop in mother’s non-treponema titre or not assessed or documented
- mother had relapse or reinfection after treatment
what is the evaluation for a child with suspected congenital syphilis (7)
physical exam (must have audiologic testing and an eye exam)
CBC
LFTs
serology
lumbar puncture- to see if there is CNS disease (if so must be repeated in 6 months)
skeletal survey (primarily looking at long bones)
direct detection- dark field microscopy/direct fluorescent Ab
what is the treatment of congenital syphilis
10-14 days of IV Pen G
asymptomatic, mother adequately treated- close clinical follow-up
two month old term infant, asymptomatic at birth. Now hypotonic and macrocephalic. what is the cause?
toxoplasmosis
what are 3 investigations to confirm toxoplasmosis?
serology- IgM/IgG/ IgA
PCR on CSF, serum, urine
placental pathology
what is seen on LP with toxoplasmosis?
lymphocytic pleocytosis
elevated CSF protein (often very high)**
what is the classic triad for toxoplasmosis?
HCC
hydrocephalus
cerebral calcifications (intraparenchymal calcifications)
chorioretinitis
toxoplasmosis in 3rd trimester- how do they present?
untreated the majority will go on to develop disease
Chorioretinitis most common manifestation