ID Virulence Factors

Question 0

Influenza virus

Answer 0

Hemagglutin - promotes viral entry
Neuraminidase - promotes progeny virion release
Rapid genetic changes

Question 1

S. Pyogenes toxins

Answer 1

Pyrogenic exotoxins: acts as a superantigen inducing fever and shock; associated with scarlet fever and strep toxic shock

Streptolysin O&S: Damages erythrocyte membranes, causing beta hemolyisis

Question 2

Strep. Pneumo

Answer 2

Polysaccharide capsule. IgA protease. Alpha-hemolytic, optic hub sensitive

Meningitis, otitis media, pneumonia, sinusitis, sepsis in sickle cell disease and splenectomy

Question 3

C. Diff

Answer 3

Toxins:

• enterotoxin A: watery diarrhea
• cytotoxine B: colonic epithelial cell necrosis and fibrin deposition –> damages cytoskeleton integrity