Oncogenes

Question 0

BLC-2

Answer 0

Gene product: Antiapoptotic
Tumor: follicular and undifferentiated lymphoma
T(14;18)

Question 1

BCR-ABL

Answer 1

Gene product: Tyrosine Kinase

Tumor: CML - good prognosis , ALL - poor prognosis, t(9;22) Philadelphia chromosome

Question 2

BRAF

Answer 2

Gene product: Serine/Threonine Kinase

Tumor: Melanoma, NHL

Question 3

C-kit

Answer 3

Gene product: Cytokines receptor

Tumor: GIST

Question 4

C-myc

Answer 4

Gene product: transcription factor
Tumor: Burkitt Lymphoma
T(18;14) bcl2 activation (Antiapoptotic)

Question 5

HER2/neu (c-erbB2)

Answer 5

Gene product: Tyrosine Kinase

Tumor: breast, ovarian, and gastric

Question 6

L-myc

Answer 6

Gene product: transcription factor

Lung tumor

Question 7

N-myc

Answer 7

Gene product: transcription factor

Neuroblastoma (adrenal medullary tumor - derived from neural crest cells)

Question 8

RAS

Answer 8

Gene product: GTPase

Colon cancer, lung cancer, pancreatic cancer

Question 9

RET

Answer 9

Gene product: Tyrosine Kinase

Tumor: MEN 2A and 2B, medullary thyroid cancer

Question 10

T(15;17)

Answer 10

Gene product: RAR disrupted
Tumor: APL t(15;17), DIC common
Tx: retinoic acid (vitamin A)

Question 11

Cyclin D1

Answer 11

Gene product: t(11;14)

Tumor: mantle cell lymphoma

Question 12

JAK2 kinase mutation

Answer 12

Gene product:
Tumor: polycythemia Vera
Hyperviscosity -headache and blurry headache, budd chiari syndrome, flushed face

Also essential thrombocythemia, but platelets increased with increased risk of bleeding (platelet dysfunctional) or thrombosis ( over active platelets)