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Surgical Pathology > IHC > Flashcards

IHC Flashcards

1
Q

Vimentin (generally not useful for diagnosis)

A

Mesenchymal

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2
Q

Cytokeratins, EMA [see epithelial primer]

A

Epithelial

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3
Q

Desmin, muscle-specific actin, smooth muscle actin, calponin, h-caldesmon, smooth muscle myosin heavy chain

A

Smooth muscle

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4
Q

Desmin, MyoD, muscle-specific actn, myogenin

A

Skeletal muscle

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5
Q

CD34, CD31, ERG, Fli-1, D2-40 (lymphatic), Factor VIII

A

Endothelial

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6
Q

Polyphenotypic markers: smooth muscle (complete phenotype – smooth muscle actin, calponin, others), neural (S100), glial (GFAP), epithelial (CK), and basal/stem cell factor (p40/p63)

A

Myoepithelial

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7
Q

Partial smooth muscle phenotype: actins (MSA, SMA) in “tram-track” distribution and calponin but not h-caldesmon

A

Myofibroblastic

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8
Q

S100 (IHC generally not used)

A

Lipomatous

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9
Q

SOX10, S100, HMB45, Melan-A/MART-1, MITF, tyrosinase

A

Melanocytic

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10
Q

SYN, CHR, CD56, INSM1

A

Neuroendocrine

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11
Q

GFAP, OLIG2

A

Glial

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12
Q

Neuronal

A

Neurofilament, NeuN, SYN

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13
Q

SOX10, S100

A

Nerve sheath (Schwannian)

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14
Q

PAS (general); BCL10, trypsin, chymotrypsin, and lipase (pancreas); SOX10 and DOG-1 (salivary)

A

Serous acinar cells

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15
Q

Pan-hematopoietic: CD45/LCA Pan-B cell: CD20, CD19, CD79a, PAX5

Pan-T cell: CD3, CD43

Plasma cell: CD138, κ/λ light chains (normal κ:λ ratio is 2–3:1)

Myeloid: CD43, CD117/c-kit, CD34, MPO

MANY others [see hemepath section]

A

Hematopoietic

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16
Q

CD68, CD163, enzymes (lysozyme/muramidase, α1-antitrypsin)

A

Histiocytic

17
Q

Name the IHC: Lung, thyroid, + small cell CA of ANY site!

A

TTF-1

18
Q

Lung, some renal, GYN clear cell carcinoma, rarely thyroid

A

Napsin A

19
Q

IHC that stains: Thyroid, renal, GYN

A

PAX8

20
Q

Breast, GYN

A

ER

21
Q

Breast, urothelial, parathyroid; sensitive but NOT specific (stains many SqCCs, mesotheliomas + other)

A

GATA-3

22
Q

GYN serous carcinomas (also mesotheliomas, some sarcomas)

A

WT1

23
Q

Colorectum (diffuse), pancreas (focal), gastric (focal), enteric carcinomas of any site

A

CDX2

Surgical Pathology (10 decks)

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