IHC

Question 1

Positive IHC in small cell carcinoma (neuroendocrine)

Answer 1

Chromogranin, CD56, synaptophysin, p16

Question 2

Mutations in clear cell carcinoma

Answer 2

AT-rich interaction domain 1A [ARID1A] (40%)

phosphatidylinositol-4,5-bisphosphate 3-kinase [PIK3] catalytic subunit alpha [PIK3CA].

Question 3

PAX8 cancers

Answer 3

Mullerian, usually ER/PR positive

Question 4

CK20 positive cancers

Answer 4

Mucinous GI cancers

Question 5

CK7 positive cancers

Answer 5

Ovarian mucinous

Question 6

CPS score

Answer 6

number of PD⁠-⁠L1–staining cells (tumor cells, lymphocytes, macrophages) relative to all viable tumor cells.