IL's and CD's Flashcards
(23 cards)
IL-1
Pro-inflammatory, pyrogen (like IL-6)
IL-2
Promotes T Cell Growth/Activation
Can act in autocrine fashion
IL-4
Promotes B Cell Development
Promotes Class switching to IgE/IgG
Promotes differentiation to TH2 CD4+ T Cells
Inhibits differentiation to TH1 CD4+ T Cells
IL-5
Promotes Class switching to IgA
Enhances eosinophil activity
IL-6
Pro-inflammatory, pyrogen (like IL-1)
IL-8
Recruits neutrophils
IL-10
Anti-inflammatory, turns off immune system
IL-12
T Cell Growth
Promotes differentiation to TH1 CD4+ T Cells
IL-13
Activates Eosinophils
IL-17
Promotes neutrophilic inflammation
Through upregulation of TH17 CD4+ T Cells
TNF-alpha
Pro-inflammatory, activates COX
Increases breakdown of membrane phospholipids to arachidonic acid, and drives formation of prostaglandins and leukotrienes
TGF-beta
Anti-inflammatory, recruit wound healing fibroblasts, contributor to fibrosis
IFN-gamma
Stimulates phagocytosis by macrophages and expression of MHC I and MHC II
Promotes differentiation to TH1 CD4+ T Cells
Inhibits differentiation to TH2 CD4+ T Cells
CD3
Present on ALL T Cells
CD4
Expressed on Helper T Cells
CD8
Expressed on Cytotoxic T Cells
CD19
Expressed on B Cells
CD20
Expressed on B Cells/target in immunotherapy (mAbs)
CD28
Co-stimulatory molecule on T Cells, binds CD80/86 (B7) of B Cells/APCs, binding to B7 inhibited by CTLA4
CD40
Expressed on B Cells during activation (upregulated from CD28-B7 binding), bind CD40L on activated T Cells for full B/APC Activation in Germinal Center
CD56
Expressed on all NK Cells
CD80/86
AKA B7, expressed on antigen-activated B/APC Cells, binds to CD28 for B/T Cell activation
CD38/138
Expressed on all plasma cells
