Immune 3

Question 1

Antibodies exist in 2 forms :

Answer 1

1-Membrane bound Abs (used by B cells to interact w antigen) 2-secreted Abs

Question 2

L chains 2forms:

Answer 2

kappa (κ) & lambda (λ) (Ig has either κ or λ, never both)

Question 3

Segment of H chain between C

H 1 & C H2

Answer 3

Hinge region

Question 4

-Composed of carboxy terminal of H chain. -Determines the biological properties of Ig molecule.

Answer 4

Fc

Question 5

Highly variable zones actually make contact

with the epitope on an Ag and are called as

Answer 5

Complementarity Determining Regions

CDRs

Question 6

There are—- CDR each made of ——- AA the most variable is ——-

Answer 6

3,9-12,CDR3

Question 7

Classes of immunoglobulins are based on

Answer 7

Constant region of heavy chains

Question 8

Dimer

Answer 8

IgA

Question 9

-Monomeric: in blood and extracellular spaces -Dimeric: in mucous membranes and secretions

Answer 9

IgA

Question 10

Secretory components protect —— from ——-

Answer 10

IgA, proteolytic digestion and denaturation

Question 11

Presence in newborn means intra uterine infection, Single positive sample in serum or CSF indicates recent or active
infection, Used to detect early phase of infection

Answer 11

IgM

Question 12

4-fold rise or fall indicates active infection

A single positive sample indicates past exposure

Answer 12

IgG

Question 13

membrane immunoglobulin’s

Answer 13

mIgM and mIgD

Question 14

Enhance the binding of BCR and antigen and pass activating signal to CD19, EB virus receptor

Answer 14

CD22(CR2)

Question 15

Transmit activating signal into B cell

Answer 15

CD19

Question 16

Transmit an important co-s0mulatory signal to B cells, Upregulate expression of B7 on B cells, Participate in class switching of antibody

Answer 16

CD40 binds w CD40L

Question 17

Expressed on B cells or other APC, B7-CD28 (stimulatory), B7-CTLA-4 (Inhibitory) (cytotoxic
T lymphocyte antigen-4)

Answer 17

B7

Question 18

Generates a clone of short-lived activates effector cells and a clone of long- lived memory cells

Answer 18

Clonal selection of B cells

Question 19

Slow, low magnitude, IgM, ab decline

Answer 19

Primary immune response

Question 20

Rapid, high magnitude, IgG

Answer 20

Secondary immune response

Question 21

Derived	from	single	antibody	producing	cell	fused	with	
myeloma	cell	(neoplastic	plasma	cell) and produce

Answer 21

Hybridoma cell line, monoclonal ab

Question 22

particulate mater, including bacteria and viruses. IgM os
particularly suitable for this, as it is able to change its shape from a star form
to a form resembling a crab.

Answer 22

Agglutination

Question 23

Involves both Fab and Fc

Answer 23

Opsonization and phagocytosis, Precipitation of soluble antigens by immune complex formation.

Question 24

Direct inactivation of pathogen or toxin thereby preventing

its interaction with human cells e.g. tetanus toxin

Answer 24

Neutralization

Question 25

Abs against bacterial ciliae or flagellae will hinder their movement. only Fab is involved.

Answer 25

Immobilization of bacteria