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Histology > Immune And Lymphatic System > Flashcards

Immune And Lymphatic System Flashcards

1
Q

What is the response of innate immunity? And why is that?

A

Inflammation because it lacks immune specificity and memory

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2
Q

What are the first responders of innate immunity?

A

Neutrophils

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3
Q

Acquired immunity develops in response to antigens? What does this signify?

A

Specificity and memory

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4
Q

Passive immunity is a temporary immunity due to donated what?

A

Antibodies

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5
Q

Active immunity is a long-lasting/permanent immunity due to self exposure to antigen resulting in?

A

Memory T cells and B cells specific for antigen

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6
Q

What are the primary lymphoid organs

A

Thymus and bone marrow

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7
Q

What are the secondary lymphoid organs?

A

Lymph nodes, spleen, tonsils

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8
Q

Are spherical, tightly packed accumulations of virgin B cells and dendritic reticular cells that have not been exposed to antigens, describes what?

A

Primary follicles

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9
Q

Are derived from primary follicles that have been exposed to non-self antigens, and not present at birth describes?

A

Secondary follicles

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10
Q

Lymph follicles are sites of B cell localization and proliferation. T/F?

A

True

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11
Q

Subcutaneous-associated lymphoid tissue is found in the __ layer of the dermis

A

Papillary

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12
Q

Aggregated lymphoid tissue is beneath and in contact with the epithelium which includes…

A

Various tonsils and Peyer’s patches in the ileum

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13
Q

IgA are found where?

A

Saliva, milk, GU and respiratory tracts

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14
Q

IgD are found where?

A

On surfaces of B cells traveling to lymphoid organs

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15
Q

IgG responsible for?

A

Responsible for most antibody activity

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16
Q

IgE associated with what type of responses?

A

Allergic responses

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17
Q

IgM is the first antibody class expressed by developing __ cells?

A

B cells

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18
Q

What is the main function of major histocompatibility complex? (MHC)

A

Present antigenic peptides to T cells

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19
Q

CD8 sis a member of what superfamily?

A

Ig superfamily

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20
Q

Cd4+ T cells are helper cells that assist in __ cell differentiation

A

B cell

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21
Q

CD8+ T cells release…

A

Perforins and Fas ligand

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22
Q

CD16+ T cells aka

A

Natural killer T cells

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23
Q

Dense collagen fibers, some elastic fibers, and smooth fibers describe what part of a lymph node?

A

Capsule

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24
Q

What is the entry and exit point for vessels in a lymph node?

A

Hilus

25
Q

The outer cortex of a lymph node contains what?

A

Lymph follicles

26
Q

The cortex follicles of a lymph contain: B cells, follicular dendritic cells, and migrating dendritic cells. T/F?

A

True

27
Q

The deep (inner) cortex of a lymph node contain HEVs. T/F?

A

True

28
Q

The medulla of a lymph node is the site of lymphocyte reentry into lymph stream? T/F?

A

True

29
Q

Medulla or lymph node is an irregular arrangement of loose/tight medullary sinuses and dense/thin medullary cords

A

Loose medullary sinuses and dense medullary cords

30
Q

The cortex lobule of the thymus stains dark or light?

A

Dark

31
Q

The medulla of thymus lobule stains dark or light?

A

Light

32
Q

Double negative T cells enter cortex from __ and proliferate in __ area

A

From blood vessels, subcapsular area

33
Q

Double positive T cells move to __ cortex

A

Outer

34
Q

Single positive T cells move to __ cortex

A

Inner

35
Q

Spleen filters…

A

Blood

36
Q

Spleen converts hemoglobin to

A

Bilirubin

37
Q

Spleen produces what 2 types of cells?

A

Lymphocytes and plasma cells

38
Q

Spleen: T cells are found in the areas surrounding the central artery near the center of the white pulp. Forms the ___ sheath?

A

Pariarterial lymphatic sheath (PALS)

39
Q

Spleen: Macrophages destroy worn-out or defective RBCs/WBCs?

A

RBCs

40
Q

Spleen: Venous sinusoids are the storage site for healthy __ cells?

A

RBCs

41
Q

Splenic artery enters __

A

Hilus

42
Q

Spleen: After capillaries form, supplying white pulp, central arteries lose their white pulp investment and enter red pulp to form a ___

A

Penicillus

43
Q

Spleen: Venous sinuses are line with ___ cells?

A

Reticuloendothelial cells

44
Q

Consists of cells that typically pack areas of the lymphoid organ (mostly lymphocytes) describes…

A

Parenchyma

45
Q

Consists mostly of reticular fibers and cells, including undifferentiated cells and fixed and free macrophages describes…

A

Stroma

46
Q

Structure of a secondary lymph follicle contains a corona (cortex) and a germinal center. How do they stain?

A

Corona stain dark in its peripheral region and germinal center stains lighter

47
Q

IgM produces what kind of lymphocytes?

A

B lymphocytes

48
Q

MHC II is expressed where?

A

On the surface of B cels and antigen-presenting cells

49
Q

MHC I helps in autoimmunity how?

A

Identifies self from foreign

50
Q

CD4+ cells aka

A

Helper Cells

51
Q

CD4+ recognize antigens bound to what MHC class molecules?

A

MHC II

52
Q

CD8+ aka

A

Cytolytic T cells

53
Q

CD8+ cells recognize antigens bound to what MHC class molecules?

A

MHC I

54
Q

What is the site of lymphocyte reentry into lymph stream?

A

Medulla

55
Q

Double negative T cells proliferate where?

A

Subcapsular area

56
Q

Double positive T cells express what king of receptors?

A

BOTH CD4 and CD8 coreceptors and TCR receptors

57
Q

What kind of receptors do single positive T cells express?

A

TCR receptors and EITHER CD4 or CD8 coreceptors

58
Q

Billroth cords form red or white pulp parenchyma?

A

Red pulp

Histology (11 decks)

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