immune defadaptive

Question 1

Th1

Answer 1

il12, ifn-y –> CD8 + macrophages –> il-2, ifny, tnfa, il-10

Question 2

Th17

Answer 2

il-6, tgfb, il23 –> neutrophils, ank spond (EC pathogens) , il-17, il-21, il-22

Question 3

Treg

Answer 3

TGF-beta –> FOXP3, cd-25, il-10

Question 4

TfH

Answer 4

il6, 1b, tnfa –> GC il2, 10, 21

Question 5

Th2

Answer 5

naive t-cells stimulated bt IL4, 6 –> helper T cells (helminth, parasites) produce IL-4, 5, 13, 10

Question 6

Di George syndrome

Answer 6

deletion at 22q11.2

developmental defect of pharyngeal pouch

Question 7

Bare Lymphocyte Syndrome - type 2 polymorphisms

Answer 7

Regulatory factor X, class 2 transactivator , unwell by 3m, need BMT , failure to thrive, all infecrion types, early infan deatg

Question 8

IFN production def by effector T-cells or IL12 receptor deficiency

Answer 8

t-b cell communicate in GC –> Myobacterium

Question 9

GC ligands

Answer 9

CD40 on b CD40L on T cells activated

Question 10

Hyper IgM Syndrome

Answer 10

Xq26

Pneumocystis jiroveci , AI, malignancy , fail to thrive