immune pharm Flashcards Preview

first aid immune > immune pharm > Flashcards

Flashcards in immune pharm Deck (21):
1

Cyclosprine 

MOA

Calcineurin inhibitor;

binds to Cyclophilin

blocks T cells activation by preventing IL-2 transcription

2

cyclosporine 

main side effect

nephrotoxicity

 

other: viral infection, lymphomas. HTN (vasoconstriction of eff/aff artioles in kidney)

gingival hyperplasia, hirtuisim

3

Tacrolimus

pimecrolimus

tacrolimus - systemically given for transplant rejection

 

 

 

 

both used for topically for eczema

4

Tacrolimus (FK506) and pimcrolimus 

MOA

CALCINEURIN INHIBITOR

bind to FK506 binding protein (FKBP) -->

Blocks T cell activation by inhbiting production (transcription) of IL-2

5

tacrolimus (FK506) and Pimecrolimus 

main sideeffects

both nephrotoxicity( bc calcineurin inhibitor)

tacrolimus - Neurotoxicty!!! (HA, parethesias)

6

Sirolimus (Rapamycin) 

mTOR inhibitor

binds FK binding protein -12 (FKBP-12) --> inhibits mTOR (mammalian target of rapamycin) -->Blocks T cell activationand B-celll differentiation by preventing response to IL-2

7

Main side effect of sirolimus (rapamycin)

not nephrotoxic!!

8

Mycophenolate mofetil

moa?

 

used for lupus

 

 

reversibly inhibits inosine monophosphate (IMP) dehydrogenase --> inhibits purine GUANINE synthesis of B and T cells (prevents lymphocyte proliferation)

9

Thalidomide 

 

main sided effect if given to pregnant mom 

(teratogenic)

Phocomelia 

(hyperplasia fused fingers/hands)

10

Thalidomide

MOA

Suppresses TNF-a production, 

increases NK cells and IL-2 

the suppresson of TNF a tx erythema nodosum leprosum (hansen disease)

inc nk cells --> tx multiple myeloma

11

infliximab 

adalimumab

 

MOA?

Etanercept (decoy receptor)

moa

 TNF-a  blockers

 

etanercept (decoy receptor) ​it mimics TNF-a receptor and binds it all up

12

what drug binds to CD 20 

used to treat

B cell non hodgkin lymphoma

CLL

RA, ITP

Rituximab

13

what drug targets IgE 

txs refractory allergic asthma

prevents IgE binding to FceRI

omalizumab

14

digoxin immune Fab

txs?

digoxin overdose 

it targets digoxin

15

what drug is an antibody toward

platelet glycoproteins IIb/IIIa

Abciximab

 

" IIb * IIIa = absiximab"

 

used in pts that have mi, unstable angina

16

what drug antibody targets 

HER2/neu

 

txs breast cancer, gastric cancer

Trastuzumab

17

inhibits IMG dehydrogenase

mycophenolate

18

binds FK-binding protein leading to loss of IL-2 production

tacrolimus (FK506), Pimecrolimus

19

binds FKBP-12 leading to inhibition of mTOR and inhibition of T cell proliferation

sirolimus

20

used for lupus nephritis

azathioprine

off label: mycophenolate, cyclosporine

21

metabolized by xanthine oxidase, therefore allopurinol will inc its toxicity

 

azathioprine