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Flashcards in Interleukins Deck (30):
1

IL-2`

PROLIFERATION of T CELLS

2

IL-4

proliferation of B cells, Th 0 --> Th2 

3

IL-5

proliferation of B cells

4

IL-10

Inhibits  Th1 and macrophages

5

IL-12 

th0 --> th1 cells

6

IFN GAMMA

activates Macrophages 

inhibits Th2 cells

7

what do Th1 cells mainly produce

IL-2

IFN gamma

8

what do Th2 cells mainly produce

IL-4

IL-5

IL-10

9

What produces IL-12 

macrophages.

and also dendritic cells?

10

IL-10 inhibits 

Th 1 cells

 

also IL-4 inhibits them too.

11

IFN-gamma inhibits 

Th2 cells

12

what cytokines are produce by 

Th 1 cells

IL-2

IL3

IFN-gamma

13

what cytokines are produce by

Th2 cells 

 

IL-3

IL-4

IL-5

IL-10

14

what cytokines 

promote growth and differentiation of 

B cells

IL-4

IL-5

15

What cytokine promotes 

growth and activation of EOSINOPHILS

IL-5

Remember is associated with mucus 

16

what cytokines are 

pyrogens 

secreted by macrophages

IL-1

IL-6

17

What cells secrete IL-12  that functions to?

macrophages secrete IL-12

 

functions to stimulate Th0 cells to differentiate into Th1 , and activates NK cells

 

 

18

IL-12 def can result in

mycobacterial infections

because no IL-12 to stimulate differentiation into Th1 cells thus no secretion of IFN gamma from TH1 to activate macrophages

19

what cytokine enhances synthesis

of IgE and IgG

 

" BEG 4 it"

IL-4

20

what cytokine enhances synthesis  of 

IgA

IL-5

21

What cytokines mediate inflammation

(acute phase cytokines)

IL-1

IL-6

TNF-a produced by macrophages

22

secreted by 

Th-1 cells and activates macrophages**** 

IFN-gamma

23

secreted by Th-2 cells

and inhibits macrophage activation

(or inhibits activated macrophages)

IL-10

24

inhibits production of 

Th1 cells

IL-10

25

INHIBITS production of 

Th-2 cells 

IFN-gamma

26

cytokine released by virus infected cells

IFN-a

 

IFN - B

27

what cytokine

supports growth and differentiation of bone marrow stem cells

IL-3

28

Supprots T cell 

proliferation, differentiation, and activation

IL-2

Secreted by TH-1 cells 

29

High dose of IL-2 

can treat what and whats the mech

high dose of il-2 --> reduction in tumor cells

by?

*** enhancing activity of NK cells  

30

what is the function of macrophages in the spleen

remove encapsulated bacteria

remove dysfunction red cells