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Flashcards in Immune Response Deck (15)
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1
Q

Type I HS: Which Ab and found on what cells?

A

IgE on mast cells and basophils

2
Q

rate of type I HS?

A

FAST - anaphylaxis bc preformed Abs

3
Q

Type II HS: Ab(s) invovled?

A

IgM and IgG

4
Q

3 mech of type II HS?

A
  1. opsonization
  2. complement mediated lysis
  3. Ab-dep cell-med cytotox (ADCC) - due to NK
5
Q

Type II HS aka:

A

cy-2-toxic

Ab and complement lead to MAC

6
Q

test for type II HS?

A

direct and indirect Coombs

7
Q

Mech of type III HS?

A
  1. Ag-Ab (IgG) complex activ complement
  2. attracts neutrophils
  3. neutrophils release lysosomal enz
8
Q

type 3 reactions - what 3 things stuck together?

A

Ag - Ab - complement

9
Q

type III - serum sickness - mech?

A

Ab to foreign protein produced (5 days), IC form and deposit in membrane, fix complement (–>tissue damage), more common than arthus

10
Q

what causes serum sickness?

A

drugs acting as haptens - symptoms of fever, urticaria, arthralgia, proteinuria, lymphadenopathy, 5-10days after exposure

11
Q

arthus rxn (type III) mech?

A

intradermal injection of Ag induce Ab –>form Ab-Ag complex in skin. characterized by edema, necrosis, activation of complement

12
Q

test for arthus rxn?

A

immunoflourescent staining

13
Q

type IV HS aka:

A

4th and LAST - delayed - cell mediated

14
Q

4 T’s of type IV HS?

A

T lymphocytes
Transplant rejection
TB skin test
Touching (contact dermatitis)

15
Q

A.C.I.D of hypersensitivies stands for?

A

A - Anaphylactive and Atopic (type I)
C - Cytotoxic (Ab mediated) - type II
I - Immune complex (type III)
D - Delayed (cell mediated) type IV