path - tumor markers and oncogenic microbes Flashcards
(20 cards)
PSA
prostatic specific antigen
used to follow prostatic carcinoma
can also be elev in BPH and prostitis
Prostatic Acid Phosphatase
prostate carcinoma
CEA
CarcinoEmbryonic Antigen
non-specific but produced by 70% of colorectal and panc cancer
also prod by gastric, breast, and medullary thyroid carcinoma
alpha-fetoprotein
normally made by fetus
hepatocellular carcinomas
nonseminomatous germ cell tumors (ie testis, ovary)
Beta-hCG
Hydatidiform moles
Choriocarcinomas (Gestational trophoblastic dz)
hCG - commonly assoc with pregnancy
CA-125
ovarian cancer
S-100
melanoma, neural tumors, schwannomas
Alkaline Phosphatase
metastatis to bone, liver, Paget’s dz of bone
Bombesin
neuroblastoma, lung and gastric cancer
TRAP
Tartrate-Resistant Acid Phosphatase (TRAP)
HAIRY cell leukemia - a B cell neoplasia
TRAP the HAIRY animal
CA-19-9
pancreatic adenocarcinoma
calcitonin
medullary thyroid carcinoma
oncogenic microbes: HTLV-1
assoc cancer?
adult T cell leuk/lymphoma
oncogenic microbes: HBV, HCV
assoc cancer?
hepatocellular carcinoma
oncogenic microbes: EBV
assoc cancer?
burkitt’s lymphoma, Hodgkins, nasopharyngeal carc, CNS lymphoma (in immunocomp)
oncogenic microbes: HPV
assoc cancer?
cervical carc (16,18), penile/anal carc, upper resp SCC
oncogenic microbes: HHV-8 (Kaposi sarcoma - assoc herpesvirus)
assoc cancer?
kaposi sarcoma, body cavity fluid B cell lymphoma
oncogenic microbes: H.pylori
assoc cancer?
Gastric adenocarcinoma and lymphoma
oncogenic microbes: schistosoma haematobium
assoc cancer?
bladder cancer (squamous cell)
oncogenic microbes: liver fluke (Clonorchis sinensis)
assoc cancer?
Cholangiocarcinoma
