immunity Flashcards
(23 cards)
what are the two types of immunity?
innate and adaptive
which animals have innate immunity
all
which animals have acquired immunity?`
vertebrates only
what are the two types of innate immunity?
Barrier Defense and Internal Defence
examples of barrier defense
skin, mucous membranes, secretions,
examples of internal defense
phagocytic cells, natural killer cells, antimicrobial proteins, inflammatory response.
Adaptive Immunity is broken down into 2 types:
Humeral (fluid/free floating) and Cell Mediated (specific)
what are the functions of mucous cells
they do nothing but produce mucous. (like old ladies make food for people in hard times)
what is the biggest difference between adaptive and innate immunity?
innate just kills stuff it doesn’t recognize. Adaptive very specific and finds ways to kill it’s enemies.
what is the direct response to histamine?
vasodilation ONLY. Swelling, heat, etc are indirect “side effects”
what are TRLs and what do they do?
Toll-like Receptor. They initiate innate immune response by recognizing things that should not be in animal cells (like double stranded RNA or CpG DNA)
what are interferons
They are released by virally infected cells and enter other cells to “warn them”
what releases defensins
Macrophages
what cells participate in the Humeral response
B-cell and Helper T-cell
What cells participate in the Cell mediated response?
Cytotoxic T-Cells and Helper T-Cells
What happens if the granzyme produced by the Cytotoxic-T Cell doesn’t kill the perforated Cell?
The b cells will get it because it is now free floating.
difference between T and B cell antigen receptors
B-Cell has 2 light and 2 heavy chains and T-Cell has Alpha and Beta Chains
IgM
(Pentamer) First response, related to time since last exposure
IgG
(monomer) crosses placenta, most common in blood
IgA
(dimer)Present in secretions including mucous and breast milk
IgE
(monomer) Allergic reactions
IgD
(monomer) on virgin B cells
What do dendrite cells do
Promote adaptive immunity. exist outside of lymph system but migrate into it after exposure to pathogens.