Immunity Flashcards
(31 cards)
A pathway of complement system that is directly initiated by nonimmunologic stimuli, such as an invading microorganism?
Alternate Pathway
A type of HLA antigen that is chiefly found on immunocompetent cells?
Class II antigen
Allergic reaction, anaphylaxis and angioedema are examples of this type of hypersensitivity.
Type I Immediate Hypersensitivity
A type of hypersensitivity wherein complement-fixing antibodies react with antigens which results in cell lysis and destruction? Give example
Type II Cytotoxic Hypersensitivity
e.g Hemolytic Transfusion reaction, Goodpasture syndrome, Graves disease
A type of hypersensitivity wherein exogenous antibodies produced in response to exposure to an antigen combines with antigen resulting in antigen-antibody complexes which are then deposited at vessels walls or serosal surfaces? Give example.
Type III Immune Complex Hypersensitivity
eg. Serum Sickness, SLE
A congenital T-cell deficiency resulting from aberrant embryonic development of the 3rd and 4th branchial pouches?
DiGeorge Syndrome
This condition is due to failure of antibody synthesis caused by block in maturation of pre-B cells to B cells due to a mutation i the B cell tyrosine kinase (Btk) gene?
X-linked agammaglobinemia of Burton
A pathway of the complement system that is initiated by antigen-antibody complexes?
Classical Pathway
A condition with marked deficiency of both T and B cells?
Severe combined immunodeficiency disease (SCID)/ Swiss-type agammaglobinemia
An X-linked disorder with mutation in WASP gene for actin filament assembly characterized with eczema, thrombocytopenia, recurrent infections and poor antibody response to polysaccharide antigens?
Wiskott-Aldrich Syndrome
ANA with anticentromere activity is specific for what PSS variant?
CREST Syndrome Calcinosis Raynaud Phenomenon Esophageal dysfunction Sclerodactyly Telangiectasia
The antinuclear antibody that is most specific for SLE?
Anti-Sm (Smith)
What is the triad of Sjogren Syndrome?
Xerostomia (dry mouth) Keratoconjunctivitis sicca (dry eyes) One of several connective tissue or autoimmune disease
The antinuclear antibody most specific for Sjogren Syndrome?
Anti-SS-A
A disease characteristically stained with Congo Red dye and demonstrate an apple green birefringence under polarized light?
Amyloidosis
Where is the gene that codes for protein precursors of A4 amyloid seen in Alzheimer’s disease?
Chromosome 21
A condition caused by deposition of amyloid fibrils derived from immunoglobulin light chains referred to as AL protein?
Primary Amyloidosis (Immunocytic Dyscrasia Amyloidosis)
Deposition of fibrils consisting of the amyloid protein called AA protein from a precursor serum amyloid-associated protein (SAA)?
Secondary amyloidosis ( Reactive Systemic Amyloidosis)
An autoimmune disease wherein gliadin stimulates cytotoxic attack on enterocytes causing villous atrophy, manifested with diarrhea and steatorrhea?
Celiac Disease
Distinguishing feature if drug-induced SLE?
Anti-histone Antibodies
What drugs are used to treat Sjogren Syndrome?
Corticosteroids
Artificial Tears
Pilocarpine
Presence of this antibody is specific for Diffuse Scleroderma.
Anti-Scl70 (Anti-topoisomerase)
Antibody specific to Mixed Connective Tissue Disease?
Anti-RNP (Anti-Ribonucleoprotein)
Treatment for acute humoral rejection in transplanted organs?
B-cell depleting agents
