Immunity To Infectious Diseases: Viruses & Fungi Flashcards Preview

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Flashcards in Immunity To Infectious Diseases: Viruses & Fungi Deck (31)
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Viruses: 2 modes of transmission

Mucosal surfaces
Epithelial surfaces

1

Mechanism of tissue damage, cytopathic viruses

Interferes with cellular protein synthesis leading to injury/death

2

Mechanism of tissue damage,noncytopathic viruses

Viral DNA persists in host cell,causing latent infections. When expressed, protein synthesis altered, leading to disease

3

Interferon ____ is produced by fibroblasts

Beta

4

Which cytokines activate NK cell?

IL-12, IL-15

5

What prompts the NK cells to lyse a cell?

Absence of a properly functioning MHC I Marker

6

Interferon ___ is produced by leukocytes

Alpha

7

Interferon alpha increases expression of IL-__ which leads to production of IFN gamma @ T cells and NK cells

12

8

True or false. Antibodies can protect from infection and eradicate established infections

False. It cannot eradicate established infections

9

Exposure to one serological type of virus makes you resistant to all serological types. True or false?

False

10

In CMI, what does cytotoxic T cell induce in viruses?

DNA fragmentation

11

Antigenic variation is done by the following viruses except
A)influenza
B)rhinovirus
C)pox virus

C)pox virus

12

HIV does all immune evasion mechanisms below except?
A.inhibition of antigen processing
B.antigenic variation
C.infection of immunocompetent cells

A.inhibition of antigen processing

13

False about Inhibition of Ag processing
A.blockade of TAP transporter
B.removal of MHC-II molecule from ER

B. Removal of MHC-II molecule fr ER. Dapat MHC-I

14

Production of cytokine receptor molecules done by all of these except?
A)HIV
B)pox virus
C)CMV

A)HIV

15

True or false: Fungi may live within phagocytes

True

16

What are mycoses?

Generalized fungal infection

17

What does endemic mean

Present in environment

18

When do fungi become opportunistic?

Normal flora become pathogenic

19

All Patients on long-term corticosteroids are not susceptible to fungal infection. True or false?

False

20

Most important predisposing factor for clinically significant fungal infection

Compromised immunity

21

Neutrophils attach to ____ of Candida albicans

Pseudohyphae

22

Cationic peptides - fungicidal activity vs ____ phase but not ____

vs hyphal phase but not spores

23

____ inhibits respiratory burst and release of myeloperoxidase by phagocytosing neutrophils

Mannan

24

How does Candida albicans evade body's immune response?
A)inhibits interaction with neutrophils by producing factor
B)binds to neutrophil receptors
c)both a and b

A)inhibits interaction with neutrophils by producing factor

25

Cryptococcus neoformans inhibits production of these cytokines except
A.TNF
B.IL-12
C.IL-10

C.IL-10

26

Cryptococcus neoformans stimulates the production of this interferon

IL-10

27

TH1 response to intracellular fungi are ____ (protective or detrimental?)

Protective

28

TH2 response to intracellular fungi are ____ (protective or detrimental?)

Detrimental

29

The following are routes of fungal exception except:
A.superficial
B.subcutaneous
C.inhalation
D.local extension
E.subdural

E.subdural