Immuno

Question 1

what cell in inhibited by the presence of MHC1 on cells

Answer 1

NK cells

org invades cell - damages MHC1 -> hidden from rest of immune response but attacked by NK cells

Question 2

what cancer develops in Barrett’s oesophagus

Answer 2

Adenocarcinoma

Question 3

Mechanism in esophagus as a result of GORD (reflux) that results in cancer

Answer 3

Metaplasia

Question 4

what happens to the Body of the stomach in pernicious anaemia

Answer 4

atrophic gastritis (weakened stomach lining)

Question 5

what cancer do you get with H pylori

Answer 5

MALT

Question 6

what cancer do you get in coeliac if you dont follow a gluten free diet

Answer 6

lymphoma

Question 7

Most common breast malig

Answer 7

inv ductal carcinoma

DCIS = most common non-invasive

Question 8

Breast cancer - E cadherin +ve

Answer 8

inv ductal carcinoma

Question 9

Breast C - E cadherin -ve

Answer 9

inv lobular carcinoma

Question 10

Breast fibro-epithelial tumour with abundant stromal elements

Answer 10

phyllodes tumour

Question 11

Low enzyme -> hyperuricaemia/rise in blood uric acid

Answer 11

HGPRT (lesch Nyhan syndro)

Question 12

what enz regulates the rate limiting step in haem biosynthesis

Answer 12

ALA Synthase

Question 13

What enz is raised in mumps

Answer 13

Amylase S

Question 14

which biomarker raised in Rhabdomyolysis

Answer 14

Creatine Kinase

Question 15

raised anti-mitochondrial antibody

Answer 15

Primary biliary cirrhosis/cholangitis

Question 16

raised anti CCP

Answer 16

rheumatoid arth

Question 17

raised anti acetylcholine receptor Ab

Answer 17

myasthenia gravis

Question 18

anti SSB/La Ab

anti-SSA/Ro Ab

Answer 18

Sjogrens

Question 19

raised tissue transglutamase ab

Answer 19

coeliac

Question 20

raised anti endomysial an

Answer 20

coeliac

Question 21

anti smooth-muscle Ab

Answer 21

AI hep

PSC

Question 22

raised cANCA

Answer 22

small vessel vasc - esp Wegener’s Granulomatosis

Question 23

raised pANCA

Answer 23

PSC

Question 24

anti-glomerular basement memb ab

Answer 24

goodpastures

Question 25

anti IF abs

Answer 25

pernicious anaemia

Question 26

anti-microsomal Abs

Answer 26

chronic lymphocytic thyroiditis (hashimotos)

Question 27

TSHR Abs

Answer 27

Graves

Question 28

Anti Jo-1 Ab

Answer 28

polymyositis and dermatomyositis

Question 29

anti Scl70

Answer 29

systemic sclerosis

Question 30

ACAs (anti centromere Abs)

Answer 30

CREST syndro

Question 31

woman presents with dry eyes and parotid swelling

Answer 31

Sjogrens syndro

Question 32

what do you measure to measure progress of SLE

Answer 32

C3/C4 | anti ds-DNA

Question 33

Hx of multiple staph skin and soft tissue inf | Aspergillus inf

Answer 33

chronic granulomatous disease

Question 34

Hx of neutrophilia, absent pus in ulcers + delayed umbilical cord cutting

Answer 34

Leukocyte adhesion def 1

Question 35

Kid with recurrent inf, doesnt have any B cells

Answer 35

Brutons X linked gammaglobinaemia

Question 36

Kid with inf, +ve nitro blue tetrazolium

Answer 36

myeloperoxidase def

Question 37

kid with no CD4+, but CD8+ and B cells present

Answer 37

Bare lymphocyte syndro

Question 38

recurring mycobac inf | get TB following BCG vaccine

Answer 38

IFN Gamma R def

Question 39

Neck swelling - stained and gives a "starry sky" appearance

Answer 39

Burkitt's Lymphoma

Question 40

Chr mutation (9,22) -> what cancer

Answer 40

CML

Question 41

Chr mutation (15,17) -> what cancer

Answer 41

AML

Question 42

lrg cells with basophillic cytoplasm and nucelus clock-face chromatin without nuclei +/- Rouleaux

Answer 42

MM

Question 43

tense bulla on flexural surfaces of elderly, T2 hypersensitivity

Answer 43

bullous pemphigoid

Question 44

wickham striae in buccal cavity

Answer 44

Lichen Planus

Question 45

recurrent inf since birth, neutrophil count normal, nitro blue tetrazolium test - remains colourless

Answer 45

CGD

Question 46

haematuria, red and white cell casts, hypertensive, passing urine less

Answer 46

nephritic syndro

Question 47

haemoptysis, haematuria, renal F, biopsy shows crescent morphology

Answer 47

good pastures syndro | -> rapidly progressing glomeruloneph

Question 48

recurrent chest inf and bouts of diarrhoea

Answer 48

selective IgA def