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StepFun > Immuno > Flashcards

Immuno Flashcards

1
Q

Lymph Drainage:

  1. -Upper limb/lateral breast
  2. -Stomach
  3. -D/J
  4. -Sigmoid colon
  5. -Rectum
  6. -Anal Canal
  7. -Testes
  8. -Scrotum
  9. -Thigh
  10. -Lateral side of dorsum of foot
A
  1. axillary
  2. celiac
  3. SMA
  4. colic –> IM
  5. internal iliac
  6. superfical inguinal
  7. superficialand deep plexuses –> para aortic
  8. superficial inguinal
  9. superficial inguinal
  10. popliteal

*

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2
Q

Encapsulated organisms and their importance

A

Asplenic patients have increased susceptibility

Strep pneumo, Hem Influenza type B, Neisseria meningitidies, Salmonella, Klebsiella, GBS, Ecoli,Pseudomonas

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3
Q

HLA Subtypes and their assocated dz

  1. A3
  2. B27
  3. DQ2/DQ8
  4. DR2
  5. DR3
  6. DR4
  7. DR5
A
  1. Hemochroatosis
  2. PAIR - Psoriasis, Ank Spodyltis, IBD, Reactive Athritis
  3. Celiac’s
  4. MS, Hay fever, SLE, Goodpastures
  5. DM1, Grave’s
  6. DM1,RA
  7. Pernicious anemia,Hashimotos thyroiditis
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4
Q

NK Cells

  • CD receptors
  • Stimulated by
  • release
A
  • CD16 (Fc of IgG), CD56 (ADCC)
  • IL2, IL12, IFNa, IFNb
  • IFNy
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5
Q

B Cells

CD receptors
Stimulated by
release

A

CD19, 20, 21, B7m CD40, MHC1/MHC2, IgM/IgG

IL4 (makes IgE, IgG), IL5 (makes IgA)

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6
Q

Th1

  • CD receptors
  • Stimulated by/Inhibited by
  • release
A
  • CD3, CD4, CD40L, TCR, CD28
  • +:IL12, IFNy, -: IL10, IL4
  • IL2, IFNy, IL-3
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7
Q

TH2

CD receptors
Stimulated by/inhibited by
release

A
  • CD3, CD4, TCR, CD28, CD40L
  • IL4 +, IFNy -
  • IL2, IL3, IL4, IL5, IL6, IL10,IL13
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8
Q

Macrophages

Cell receptors, stimulated/inhibited by, secrete

A

CD14, CD40,MHC2, B7, Fc/C3b receptor

+ IFNy, -IL-10

Secrete: IL-1,IL-6, IL-8, IL-12, TNFa

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9
Q

Complement functions:

C3a, C3b, C5a,C5b-C9

A

C3a: anaphylaxis

C5a: anaphylaxis, neutrophil chemotaxis

C3b:opsonize, phagocytosis

C5b-C9: MAC

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10
Q

Neutrophil chemotactic signals

A

LTB4, C5a, IL-8

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11
Q

Functions of (and secreted by):

  1. IL-1
  2. IL-2
  3. IL-3
  4. IL-4
  5. IL-5
  6. IL-6
  7. IL-8
  8. IL-10
  9. IL-12
A
  1. endogenous pyrogen, causes fever, acute inflammation, activates endothelium to express adhesion molecs, induces chemokine secretion to recruit leukocyts (macrophages)
  2. strimualtes gorwth of T cells (T cells)
  3. supports growth and differention of bone marrow stem cells (T cells)
  4. induces differentiation into Th2, promotes growth of B cells, enhances class switching to IgE and IgG (Th2)
  5. promotes differenaiton of B cells, enhaces class switching to IgA, promotes eosinophil growth (Th2)
  6. endogenous pyrogen, stimulates acute phase reactants (macrophages, Th2)
  7. chemotactic factor (macrophages)
  8. modulatess inflamamtory response, inhibits macrohpages and Tcell activation, esp Th1 (Th2, reg T cells)
  9. induces diffeerentiation of T cells into TH1, activates NK cells (macrophages, B cells)
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12
Q

Fxns of:

TNFa

IFNa

IFNb

IFNy

A
  • TNFa: mediates septic shock, activates endothleum, leukocyte recruitment, vascular leak (released by macrophages)
  • inhibit viral protein synthesis, encourage ribonuclease activation
  • inhibit viral protein synthesis, encourage ribonuclease activation
  • activates macropages and Th1 cells, suppresses Th2 cells, aslo has anti viral and antitumor properties, increases MHCI/II expressoin on surface (from Th1)
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13
Q

Autoantibodies

  1. ANA
  2. ANtidsDNA/Anti Smith
  3. Antihistone
  4. Rhematoid factor, Anti-CCP (ACPA)
A
  1. SLE, nonspecific
  2. SLE
  3. Drug induced lupus
  4. RA
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14
Q

Antcentromere

A

Scleroderma (CREST)

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15
Q

Anti SCL 70 (anti DNA topoisomerase I)

A

Scleroderma (diffuse)

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16
Q
A
17
Q
  1. Antimitochondrial
  2. Iga antiendomysial, igaanti tissue transglutaminase
  3. anti basement membrane
  4. anti desmoglein
  5. antimicrosomal, antithyroglobulin, anti TPO
  6. anti JO, anti SRP, anti Mi2
  7. anti SSA
  8. Anti SSB
  9. Anti U1 RNP
  10. Anti smooth muscle
  11. Anti glutmate decarbxoylase
  12. cANCA
  13. pANCA
  14. anti thyrotropin
A
  1. primary biliary cirrhosis
  2. cleiacs
  3. goodpasutres
  4. pemphigous vulgaris
  5. hashimotos
  6. polymiositis/dermatomyositis
  7. sjogrens
  8. sjogrens
  9. mixed CTD
  10. autoimmune hepatitis
  11. T1DM
  12. GPA
  13. MPA, CSS,pauci immune crescentic GN
  14. graves disease
18
Q

Hypersensitivity disorders

A

•Hypersensitivity reactions are classified as:
–Type I (IgE-mediated allergic reactions)
–Type II (cytotoxic reactions)
–Type III (immune complex reactions)
–Type IV (cell-mediated)

(ACID: anaphylactic, cytotoxic, Immune complex, delayed cell mediated)

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