Immuno Other Flashcards
(24 cards)
autograft
graft from self
isograft/ synergistic graft
graft from identical twin or clone
allograft
graft from same species
xenograft
graft from different species
hyperacute rejection time
occurs within minutes
hyperacute rejection morphology
widespread thrombosis of graft vessels with ischemia and necrosis
problem with hyperacute rejection
pre-existing recipient antibodies react to donor antigen via compliment
acute rejection timing
weeks to months
acute rejection problem
T cells are activated agianst donor MHCs
acute rejection morphology
vasculitis of graft vessels with dense interstitial lymphocytic infiltrate
chronic rejection time
months to years
chronic rejection problem
CD4 T cells respond to recipient APCs presenting donor peptides
chronic rejection morphology
proliferation of vascular smooth muscle
parenchymal atrophy
interstitial fibrosis
arteriosclerosis
graft vs host disease
T cells from donor graft proliferate in the immunocompromised host and reject host cells
anti- beta 2 glycoprotein antibody
antiphospholipid syndrome
anticardiolipin
antiphospholipid syndrome
SLE
Anti-Smith
Anti-dsDNA
SLE
anti-histone
drug induced lupus
anti-Ro/SSA
anti-La/SSB
Sjogren Syndrome
Anti-Scl70 ( anti DNA topoisomerase 1)
Diffuse schleroderma
Anti-centromere
CREST syndrome (limited scleroderma)
Antisynthetase (anti- Jo1)
anti-SRP
anti-helicase (anti-M2)
polymyositis
dermatomyositis
antimicrosomal
antithyroglobulin
antithyroid peroxidase
Hashimotothyroiditis
anti-TSHR
Graves disease
