Immunodeficiency Flashcards
(24 cards)
is primary or secondary immune deficiency more common?
secondary
what do you see elevated eosinophils for
allergies
parasites
what do mast cells cause?
allergic reactions (lead to swelling/ anaphylaxis)
what are the 2 types of lymphocytes?
B and T cells
what can cause secondary immune deficiency?
bacterial or viral infection malignancy, malnutrition HIV, immunosuppresive therapy splenectomy nephrotic syndrome
what do you do for a sepsis evaluation?
Blood culture, Urine culture, LP
if your ANC is low what does it indicate?
strong correlation with survive and mobility
Kids with _ or more ear infections within 1 year is a warning sign for primary immunodeficiency
eight
how are many primary immunodeficiencies inherited
X linked
AR
what is SPUR
Severe
Prolonged
Unusual
Recurrent infections
when is a B cell defect usually seen?
after 6 months when maternal antibodies lost
what is the most common immune deficiency
b cells
what will a child with B cell defect show up with?
Persistent upper RTI (ear, sinus, pulm)
what immunoglobulin has the slowest synthesis
IgA
if a child presents with opportunitic infections what do they probably have a defect in?
T cells
will a child with a B cell or T cell problem have failure to thrive?
T cell problem
Profound lack of T-cell numbers or function and B-cell dysfunction resulting from absence of B cells from the gene defect itself or secondary to lack of T-cell function
SCID
absence of pus or delayed loss of umbilical cord (>2 weeks) would indicate what?
neutrophil disorder
Function in ordered integrated fashion to defend against infection and produce inflammation
complement
test for complement defect
CH50
presents with Recurrent bacterial infections
SLE-like illness
Recurrent meningococcal infections
glomerulonephritis
complement defects
where do you start with testing for immunodeficiencies
H and P CBC and Diff quantitative immunoglobulins levels specific antibody responses IgG sub class analysis
examples of secondary immunodeficiency
HIV DM sickle cell malnutrition zinc deficiency nephrotic syndrome
why is nephrotic a secondary immunodeficiency
Losing proteins (IgGs are proteins)
