Flashcards in Immunology 1 Deck (21):
What are the primary lymphoid organs?
Thymus and bone marrow
Name 4 secondary lymphoid organs
What are peyers patches?
Lymphoid tissue in wall of small intestine
What is the lamina propria?
Mucose associated secondary lymphoid tissue- thin layer of connective tissue below epithilium
How long does a lymphocyte spend in an organ before it recirculates?
How do lymphocytes leave peripheral tissue?
They drain out of tissue as tissue fluid via the lymphatics system to the lymph nodes (afferent lymphatics)
How do lymphocytes return to the blood from the lymph nodes?
Out of lymph nodes via efferent lymphatics and back to blood mainly via thoracic duct
Name the polymorphonuclear leucocytes
Name the granulocytes
Example of anti microbial secreted mediators
Antibodies, complement proteins
Name regulatory/inflammatory mediators of immunity
Cytokines and histamine
What two things does the innate system recognise?
Pathogen associated molecular patterns (pamps) eg. Viral ds DNA and pathogen recognition receptors ( PRRs) eg toll like receptors
What is an antigen?
Anything that is recognised by a lymphocyte
What is the first immune response after skin is cut?
Immediate local innate response- complement proteins and macrophages
What is the early induced response?
Innate/inflammatory: inflammatory mediators from complement macrophages and mast cells attract leucocytes and serum proteins
What happens during the later adaptive response?
Antigen carriage by dendritic cells or freely in lymph fluid results in lymphoid tissue activation of T and B lymphocytes and antibody recirculation to site of infection
How long does it take for the adaptive immune response to kick in?
What is the response to extra cellular infection?
Complement proteins, phagocytes and antibodies
What is he response to intercellular vesicular infection?
Helper t-cells if macrophage can't digest it alone
Intra-cellular cytosolic infection? Eg viruses
Interferon proteins, natural killer cells and cytotoxic cells