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Flashcards in Immunology 1 Deck (21):
1

What are the primary lymphoid organs?

Thymus and bone marrow

2

Name 4 secondary lymphoid organs

Tonsils
Lymph nodes
Spleen
Peyers patches

3

What are peyers patches?

Lymphoid tissue in wall of small intestine

4

What is the lamina propria?

Mucose associated secondary lymphoid tissue- thin layer of connective tissue below epithilium

5

How long does a lymphocyte spend in an organ before it recirculates?

1-2 days

6

How do lymphocytes leave peripheral tissue?

They drain out of tissue as tissue fluid via the lymphatics system to the lymph nodes (afferent lymphatics)

7

How do lymphocytes return to the blood from the lymph nodes?

Out of lymph nodes via efferent lymphatics and back to blood mainly via thoracic duct

8

Name the polymorphonuclear leucocytes

Neutrophils
Eosinophils
Basophils
Mast cells

9

Name the granulocytes

Neutrophils
Eosinophils
Basophils

10

Example of anti microbial secreted mediators

Antibodies, complement proteins

11

Name regulatory/inflammatory mediators of immunity

Cytokines and histamine

12

What two things does the innate system recognise?

Pathogen associated molecular patterns (pamps) eg. Viral ds DNA and pathogen recognition receptors ( PRRs) eg toll like receptors

13

What is an antigen?

Anything that is recognised by a lymphocyte

14

What is the first immune response after skin is cut?

Immediate local innate response- complement proteins and macrophages

15

What is the early induced response?

Innate/inflammatory: inflammatory mediators from complement macrophages and mast cells attract leucocytes and serum proteins

16

What happens during the later adaptive response?

Antigen carriage by dendritic cells or freely in lymph fluid results in lymphoid tissue activation of T and B lymphocytes and antibody recirculation to site of infection

17

How long does it take for the adaptive immune response to kick in?

5-7 days

18

What is the response to extra cellular infection?

Complement proteins, phagocytes and antibodies

19

What is he response to intercellular vesicular infection?

Helper t-cells if macrophage can't digest it alone

20

Intra-cellular cytosolic infection? Eg viruses

Interferon proteins, natural killer cells and cytotoxic cells

21

What is immunopathology

Diseases involving defects in or inappropriate activity of the immune system