Immunology Flashcards
Some Persian are predisposed to Chédiak-Higashi syndrome. What is their coat color (one word) ?
smoke
Which one of these diseases does not lead to immunodeficiency?
* Chédiak-Higashi syndrome
* Cyclic hematopoiesis
* Lethal acrodermatitis
* Leukocyte adhesion deficiency
Chédiak-Higashi syndrome
Morphological leukocyte change causing no immunodeficiency but leading to a bleeding tendency following platelet sotrage pool disease
Some Collies are predisposed to cyclic hematopoiesis. What is their coat color (one word) ?
grey
Which breed of cats is predisposed to a morphological abnormality in leukocytes ?
* Burmese
* Birman
* Brittish shorthair
* Burmilla
Birman
Acidophilic granulation of leukocytes
Leukocyte Adhesion Deficiency is secondary to:
* CD18 deficiency
* E-selectin deficiency
* CXCL8R deficiency
* C3 deficiency
CD18 deficiency
CD11/18 is an heterodimer that is essential for leucocyte adhesion to endothelium membrane once activated (ie through binding to ICAM-1). E-selectin is an endothelial integrin that allows leukocytes rolling. CXCL8R is IL-8 receptor that serves for signaling during adhesion.
Irish and red and white setters are predisposed to:
* Leukocyte adhesion deficiency
* Complement component 3 deficiency
* Bactericidal neutrophil defect
* Combined immunodeficiency
Leukocyte adhesion deficiency
- Complement component 3 deficiency > Brittany spaniel (one research colony)
- Bactericidal neutrophil defect > Doberman pinscher
- Combined immunodeficiency -> Sharpei
Congenital cobalamin deficiency is reported in:
* Australian cattle dog
* Australian shepherd
* Airedale terrier
* Basset hound
Australian shepherd
- Giant schnauzers
- Beagles
- Australian shepherd
- Komondor
- Border collie
Trapped neutrophil syndrome is reported in:
* Border collie
* Bearded colley
* Cardigan Welsh Corgi
* Basset hound
Border collie
Cardigan Welsh Corgi and Basset hound : X-linked severe combined immunodeficiency (research colonies)
