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Flashcards in Immunology Deck (46):
1

site of fluid absorption and entrance for circulating lymphocytes to the node

high endothelial venules
endothelial cells have signals for antigen carrying cells:
• T cells remain in the deep cortex
• B cells migrate to the nodular cortex

2

embryologic derivation of the thymus

3rd and 4th pharyngeal pouches

3

distinguishing feature of the thymic medulla

Hassall corpuscle
contains mature T cells
keratinized center

4

part of the spleen that filters blood and contains macrophages for removal of RBCs

red pulp

5

Within the spaces of the bone, medullary cavity of young long bones and spaces of spongy bone

red bone marrow

6

Bone marrow not active in blood cell formation contains adipose cells giving it the appearance of adipose tissue

yellow bone marrow
present in the medullary cavity in adults

7

mediated by molecules in the blood and mucosal secretions (antibodies) produced by B lymphocytes. Principal defense mechanism against extracellular microbes & their toxins

humoral immunity

8

Innate or adaptive?
lysozyme, complement, CRP, mucus, defensins

innate immunity

9

LPS, flagellin, ssRNA

PAMPs = pathogen-associated molecular patterns
recognized by TLRs

10

encoded for by the HLA genes

MHC
these present antigen to T cells and bind TCRs (CD3)

11

loci for MHC I
expressed on all nucleated cells
present endogenously synthesized antigens (from inside the cell -> so recognizes self)

HLA: A, B & C

12

loci for MHC II
Expressed ONLY on APCs
presents exogenously synthesized proteins (ex from bacteria & viral capsids)

HLA: DR, DP, DQ

13

HLA subtype associated with PAIR diseases:(seronegative arthropathies)
Psoriatic arthritis
Ankylosing spondylitis
Inflammatory Bowel Disease arthritis
Reactive arthritis (Reiter syndrome)

B27
(the B27 has a "pair" of engines on each wing)

14

HLA subtype associated with hemochromatosis

A3

15

HLA subtypes associated with celiac disease

DQ2/DQ8

16

HLA subtype associated with:
Multiple sclerosis
hay fever
SLE
Goodpasture

DR2

17

HLA subtype associated with:
type I DM
SLE
Graves disease

DR3

18

HLA subtype associated with:
DM type 1
Rheumatoid arthritis

DR4
a "rheum" has 4 walls"

19

HLA subtype associated with:
pernicious anemia
Hashimoto thyroiditis

DR5

20

cell that responds to absence of MHC I

NK
use perforin & granzymes to induce apoptosis of virally infected cells and tumor cells

21

T cell that directly kills virally-infected cells
Delayed type hypersensitivity (Type IV)
Acute & chronic organ rejection

CD8

22

TCRs express high affinity for self antigens & undergo apoptosis

Negative selection -> occurs in the medulla of the thymus
Positive selection occurs in the cortex and is the survival of T cells that have TCRs that can bind self MHC

23

signal 2 of T cell activation

dendritic B7 and naive T cell CD28

24

helps deliver granule contents of CTL to target cell

perforin

25

produces IL-10 and TGF-beta (anti-inflammatory cytokines)

T regs

26

immunoglobulins that fix complement

IgG and IgM

27

binds mast cells and basophils
cross-links when exposed to allergen & mediates type I hypersensitivity through release of histamine & other inflammatory mediators

IgE

28

Acute phase reactants produced by the liver in both acute and chronic inflammatory states. Induced by IL-6, IL-1, TNF-alpha, IFN-gamma

serum amyloid A
CRP -> opsonin
ferritin
fibrinogen -> correlates with ESR
hepcidin -> prevents iron release from ferritin -> anemia of chronic disease

29

complement pathway activated by microbe surface molecules

alternative pathway

30

complement pathway mediated by IgG and IgM

classic pathway
"GM makes classic cars"

31

complement proteins of anaphylaxis

C3a, C4a, C5a

32

complement component for neutrophil chemotaxis

C5a

33

complement opsonin

C3b
"C3b binds bacteria"

34

MAC

C5b-9

35

prevent complement activation on self cells

DAF (CD55) and C1 esterase inhibitor

36

deficiency causes complement-mediated lysis of RBCs & paroxysmal nocturnal hemoglobinuria

DAF

37

deficiency causes hereditary angioedema

C1 esterase inhibitor

38

increases susceptibility to recurrent Neisseria infections

C5-C9 deficiency

39

increases susceptibility to recurrent pyogenic sinus and resp tract infections, as well as type III hypersensitivity

C3 deficiency

40

activates NK cells to kill virus-infected cells

IFN-gamma

41

enhances class switching to IgA
growth & differentiation of eosinophils

IL-5

42

cytokine chemotactic for neutrophils

IL-8

43

Which cells do not have MHC I?

Red blood cells. All others do

44

MHC I molecule composition

Heavy chain & beta2 microglobulin
MHC I presents foreign antigen to cd8 T cells

45

Enzyme specific to mast cell and is elevated in drug hypersensitivity

Tryptase

46

Recurrent otitis media, sinusitis, bronchitis and GI infections
Transfusion with blood products can cause fatal anaphylaxis

Selective IgA deficiency
Form IgG antibodies to IgA