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Opthamology > Immunology > Flashcards

Flashcards in Immunology Deck (21):
1

What physical barriers does the eye have?

Flushing
Mucous layer - antiadhesive

2

What chemical barriers does the eye have?

Lysozyme
Lactoferrin & transferrin
tear lipids

3

What does lysozyme defend against?

gram -ve
fungi

4

What does lactoferrin and transferrin defend against?

gram +ve

5

What cellular defence does the eye have?

Neutrophils - attracted by chemotaxis
Macrophages - phagocytosis of damaged cells
Conjunctival mast cells - vasoactive mediators

6

What 2 things does the acquired immune system need?

Antigen presenting cells
Lymphatic drainage to node

7

What is the only part of the eye with lymphatic drainage?

Conjuctiva

8

What act as the antigen presenting cells in the conjuctiva?

Dendritic cells

9

Do the cornea and sclera have lymphatic drainage?

No

10

What type of barrier does the vitreous, choroid and the retina have?

Blood-ocular

11

What is immune privilege?

Ability to tolerate antigens without eliciting an inflammatory response

12

What body parts have immune privilege?

Brain
Testes
Placenta/foetus
Eyes

13

What is Sympathetic Ophthalmia?

rare, bilateral, granulomatous uveitis due to trauma to one eye but causes blindness in both

14

Describe sympathetic ophthalmia?

Primary mediators are T cells
at start - CD4+ helper t cells
later - CD8+ cytotoxic T cells

15

What is type 1 hypersensitivity?

immeadiate hypersensitivity

16

On encounter with an allergen, what do B cells produce?

Antigen-specific IgE antiodies

17

What is type 2 hypersensitivity?

Direct cell killing

18

What does the killing in type 2 H?

macrophages
Natural killer cells
Complement - membrane attack complex

19

What is type 3 H?

Immune complex mediated

20

What is type 4 H?

Delayed type H

21

What activates T helper cells in type 4 H?

Intracellular pathogens