Flashcards in Immunology Deck (21):
What physical barriers does the eye have?
Mucous layer - antiadhesive
What chemical barriers does the eye have?
Lactoferrin & transferrin
What does lysozyme defend against?
What does lactoferrin and transferrin defend against?
What cellular defence does the eye have?
Neutrophils - attracted by chemotaxis
Macrophages - phagocytosis of damaged cells
Conjunctival mast cells - vasoactive mediators
What 2 things does the acquired immune system need?
Antigen presenting cells
Lymphatic drainage to node
What is the only part of the eye with lymphatic drainage?
What act as the antigen presenting cells in the conjuctiva?
Do the cornea and sclera have lymphatic drainage?
What type of barrier does the vitreous, choroid and the retina have?
What is immune privilege?
Ability to tolerate antigens without eliciting an inflammatory response
What body parts have immune privilege?
What is Sympathetic Ophthalmia?
rare, bilateral, granulomatous uveitis due to trauma to one eye but causes blindness in both
Describe sympathetic ophthalmia?
Primary mediators are T cells
at start - CD4+ helper t cells
later - CD8+ cytotoxic T cells
What is type 1 hypersensitivity?
On encounter with an allergen, what do B cells produce?
Antigen-specific IgE antiodies
What is type 2 hypersensitivity?
Direct cell killing
What does the killing in type 2 H?
Natural killer cells
Complement - membrane attack complex
What is type 3 H?
Immune complex mediated
What is type 4 H?
Delayed type H